{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T18:57:10Z","timestamp":1789412230584,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP23K06438"],"award-info":[{"award-number":["JP23K06438"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003837","name":"Ichiro Kanehara Foundation for the Promotion of Medical Sciences and Medical Care","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003837","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes Chromosomes &amp;amp; Cancer"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Myoepithelioma\u2010like hyalinizing epithelioid tumor (MHET) is a rare mesenchymal neoplasm characterized by rearrangements of the\n                    <jats:italic>OGT<\/jats:italic>\n                    gene. MHET typically presents as a small tumor in the subcutis and generally follows a benign clinical course. Histologically, MHET is characterized by a hyalinized stroma exhibiting a distinctive \u201ctwo\u2010tone\u201d appearance, epithelioid tumor cells with cellular processes encircling matrix globules, and a minor spindle cell component. The tumor also demonstrates rich vasculature with occasional fringe\u2010like vessels, accompanied by perivascular concentric spindle cell proliferation and hyalinization. Nearly all documented\n                    <jats:italic>OGT<\/jats:italic>\n                    fusions in MHET are intraexonic; however, their precise genomic DNA breakpoints and the mechanisms underlying fusion transcript generation remain unclear. We report a case of MHET in a 17\u2010year\u2010old boy and investigate the genomic breakpoint of the fusion gene. Although the tumor showed atypical features, including large size, intramuscular location, and focal cytokeratin (CAM5.2) expression, the histologic findings were characteristic of MHET. Reverse transcription\u2010polymerase chain reaction (RT\u2010PCR) identified an intraexonic, in\u2010frame\n                    <jats:italic>OGT::FOXO3<\/jats:italic>\n                    fusion transcript. To clarify the genomic breakpoint, nanopore DNA sequencing demonstrated that the DNA breakpoint was identical to the fusion junction in the mRNA transcript. These findings demonstrate that the fusion transcript was generated directly from rearranged genomic DNA without splice site involvement. This mechanism may contribute to the rarity of MHET and warrants further investigation.\n                  <\/jats:p>","DOI":"10.1002\/gcc.70155","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T21:25:56Z","timestamp":1784928356000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Intramuscular Myoepithelioma\u2010Like Hyalinizing Epithelioid Tumor With\n                    <i>OGT::FOXO3<\/i>\n                    Intraexonic\n                    <scp>DNA<\/scp>\n                    Fusion Confirmed by Nanopore Sequencing"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2362-7179","authenticated-orcid":false,"given":"Naoki","family":"Takeda","sequence":"first","affiliation":[{"name":"Division of Surgical Pathology Chiba Cancer Center  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6991-747X","authenticated-orcid":false,"given":"Naohiro","family":"Makise","sequence":"additional","affiliation":[{"name":"Division of Surgical Pathology Chiba Cancer Center  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajime","family":"Kageyama","sequence":"additional","affiliation":[{"name":"Division of Surgical Pathology Chiba Cancer Center  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariko","family":"Oikawa","sequence":"additional","affiliation":[{"name":"Division of Surgical Pathology Chiba Cancer Center  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4056-3487","authenticated-orcid":false,"given":"Yusuke","family":"Amano","sequence":"additional","affiliation":[{"name":"Division of Surgical Pathology Chiba Cancer Center  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Sugiyama","sequence":"additional","affiliation":[{"name":"Division of Surgical Pathology Chiba Cancer Center  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0515-088X","authenticated-orcid":false,"given":"Hideyuki","family":"Kinoshita","sequence":"additional","affiliation":[{"name":"Division of Orthopaedic Surgery Chiba Cancer Center  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Hagiwara","sequence":"additional","affiliation":[{"name":"Division of Orthopaedic Surgery Chiba Cancer Center  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8982-2278","authenticated-orcid":false,"given":"Hiroto","family":"Kamoda","sequence":"additional","affiliation":[{"name":"Division of Orthopaedic Surgery Chiba Cancer Center  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsukasa","family":"Yonemoto","sequence":"additional","affiliation":[{"name":"Division of Orthopaedic Surgery Chiba Cancer Center  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4146-3629","authenticated-orcid":false,"given":"Masahito","family":"Kawazu","sequence":"additional","affiliation":[{"name":"Division of Cell Therapy Chiba Cancer Center  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akinobu","family":"Araki","sequence":"additional","affiliation":[{"name":"Division of Surgical Pathology Chiba Cancer Center  Chiba 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