{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T12:23:41Z","timestamp":1789129421214,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Soft tissue tumors with chondroid matrix represent a heterogeneous group with persistent diagnostic challenges. Advances in molecular diagnostics have identified recurrent gene fusions in several chondroid neoplasms, predominantly involving\n                    <jats:italic>FN1.<\/jats:italic>\n                    Here, we report two cases of chondroid tumors harboring a novel\n                    <jats:italic>FOS::PABPN1<\/jats:italic>\n                    fusion. The patients were young and presented with small, deep, peri\u2010osseous nodules located in the extremities. Histologically, the tumors were well\u2010circumscribed and lobulated. Both cases presented fibro\u2010cartilaginous and spindle cell areas. No cytonuclear atypia, mitoses, or necrosis were observed. Immunohistochemistry (performed in Case 2) revealed positivity for\n                    <jats:italic>S100, CD34,<\/jats:italic>\n                    and\n                    <jats:italic>FOS<\/jats:italic>\n                    , with negativity for\n                    <jats:italic>MDM2, HMGA2<\/jats:italic>\n                    ,\n                    <jats:italic>PLAG1<\/jats:italic>\n                    , and desmin. RNA sequencing identified an identical in\u2010frame\n                    <jats:italic>FOS::PABPN1<\/jats:italic>\n                    fusion transcript in both tumors. Unsupervised transcriptomic clustering positioned the cases near synovial chondromatoses and other chondroid lesions, despite the absence of\n                    <jats:italic>FN1<\/jats:italic>\n                    rearrangements. Massive overexpression of the\n                    <jats:italic>WIF1<\/jats:italic>\n                    (\n                    <jats:italic>Wnt<\/jats:italic>\n                    Inhibitory Factor1) gene was also observed. To our knowledge, this is the first description of FOS rearrangement in mesenchymal tumors exhibiting chondroid differentiation. The\n                    <jats:italic>FOS::PABPN1<\/jats:italic>\n                    fusion expands the spectrum of\n                    <jats:italic>FOS<\/jats:italic>\n                    \u2010altered neoplasms beyond osteoblastic and vascular lesions and defines a potential new molecular subset of benign chondroid tumors. These findings highlight the utility of RNA sequencing in the diagnosis of chondroid neoplasms in order to identify rearrangement (of\n                    <jats:italic>FN1, THBS1<\/jats:italic>\n                    or\n                    <jats:italic>FOS<\/jats:italic>\n                    ) or\n                    <jats:italic>IDH1\/2.<\/jats:italic>\n                    The consistent upregulation of\n                    <jats:italic>WIF1<\/jats:italic>\n                    may represent a potential diagnostic biomarker.\n                  <\/jats:p>","DOI":"10.1002\/gcc.70157","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T13:05:54Z","timestamp":1786107954000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chondroid Soft Tissue Tumors With\n                    <scp>FOS<\/scp>\n                    ::\n                    <scp>PABPN1<\/scp>\n                    Fusion: A New Entity? About Two Cases"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-9661-6865","authenticated-orcid":false,"given":"Jinane","family":"Kharmoum","sequence":"first","affiliation":[{"name":"Department of Biopathology Centre Leon Berard  Lyon France"},{"name":"Preclinical Basic Sciences Laboratory, Faculty of Medicine and Pharmacy of Tangiers Abdelmalek Essaadi University  Tetouan Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexendra","family":"Meurgey","sequence":"additional","affiliation":[{"name":"Department of Biopathology Centre Leon Berard  Lyon France"},{"name":"Centre de Recherche en Canc\u00e9rologie de Lyon, INSERM U1052 \u2010 CNRS UMR5286, Centre L\u00e9on B\u00e9rard Universit\u00e9 Lyon 1  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1118-950X","authenticated-orcid":false,"given":"Daniel","family":"pissaloux","sequence":"additional","affiliation":[{"name":"Department of Biopathology Centre Leon Berard  Lyon France"},{"name":"Centre de Recherche en Canc\u00e9rologie de Lyon, INSERM U1052 \u2010 CNRS UMR5286, Centre L\u00e9on B\u00e9rard Universit\u00e9 Lyon 1  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0640-5891","authenticated-orcid":false,"given":"Sanae","family":"Chaib","sequence":"additional","affiliation":[{"name":"Department of Biopathology Centre Leon Berard  Lyon France"},{"name":"Preclinical Basic Sciences Laboratory, Faculty of Medicine and Pharmacy of Tangiers Abdelmalek Essaadi University  Tetouan Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9882-2162","authenticated-orcid":false,"given":"Nicolas","family":"Macagno","sequence":"additional","affiliation":[{"name":"Department of Pathology and Neuropathology La Timone Hospital  Marseille France"},{"name":"INSERM MMG Aix Marseille University  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariame","family":"Chraibi","sequence":"additional","affiliation":[{"name":"Preclinical Basic Sciences Laboratory, Faculty of Medicine and Pharmacy of Tangiers Abdelmalek Essaadi University  Tetouan Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4731-7817","authenticated-orcid":false,"given":"Franck","family":"Tirode","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Canc\u00e9rologie de Lyon, INSERM U1052 \u2010 CNRS UMR5286, Centre L\u00e9on B\u00e9rard Universit\u00e9 Lyon 1  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0434-636X","authenticated-orcid":false,"given":"Marie","family":"Karanian","sequence":"additional","affiliation":[{"name":"Department of Biopathology Centre Leon Berard  Lyon France"},{"name":"Centre de Recherche en Canc\u00e9rologie de Lyon, INSERM U1052 \u2010 CNRS UMR5286, Centre L\u00e9on B\u00e9rard Universit\u00e9 Lyon 1  Lyon 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