{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:23:32Z","timestamp":1787840612442,"version":"build-2784847793"},"reference-count":19,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Constitutional trisomy 8 mosaicism (CT8M) is a rare chromosomal disorder associated with congenital anomalies and hematologic malignancies, although its hematologic spectrum remains poorly defined. We report two institutional cases and performed a systematic review restricted to patients with trisomy 8 confirmed in both hematopoietic and non\u2010hematopoietic tissues. Among 61 patients, hematologic abnormalities ranged from macrocytosis and cytopenias to dysplastic bone marrow changes and malignancies. No clear age\u2010dependent peak of transformation emerged. Our findings suggest that CT8M represents a lifelong state of mosaic hematopoiesis with variable hematologic manifestations and uncertain malignant potential.<\/jats:p>","DOI":"10.1002\/gcc.70163","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:49:37Z","timestamp":1787024977000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hematologic Manifestations of Constitutional Trisomy 8 Mosaicism: Two Cases and a Systematic Review of Cytogenetically Confirmed Patients"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7374-5579","authenticated-orcid":false,"given":"Andrea","family":"Magni","sequence":"first","affiliation":[{"name":"School of Medicine and Surgery University of Milano\u2010Bicocca  Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4109-5395","authenticated-orcid":false,"given":"Riccardo","family":"Pagani","sequence":"additional","affiliation":[{"name":"School of Medicine and Surgery University of Milano\u2010Bicocca  Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0686-6203","authenticated-orcid":false,"given":"Antonio Maria","family":"Alviano","sequence":"additional","affiliation":[{"name":"School of Medicine and Surgery University of Milano\u2010Bicocca  Monza Italy"},{"name":"Department of Pathology Fondazione IRCCS San Gerardo Dei Tintori  Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0490-8637","authenticated-orcid":false,"given":"Lucia Pia","family":"Bruno","sequence":"additional","affiliation":[{"name":"School of Medicine and Surgery University of Milano\u2010Bicocca  Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8419-1566","authenticated-orcid":false,"given":"Rebecca","family":"Fumagalli","sequence":"additional","affiliation":[{"name":"School of Medicine and Surgery University of Milano\u2010Bicocca  Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7077-8422","authenticated-orcid":false,"given":"Grazia","family":"Fazio","sequence":"additional","affiliation":[{"name":"School of Medicine and Surgery University of Milano\u2010Bicocca  Monza Italy"},{"name":"Centro Tettamanti Fondazione IRCCS San Gerardo Dei Tintori  Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Galbiati","sequence":"additional","affiliation":[{"name":"S.C. 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