{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:23:28Z","timestamp":1787840608877,"version":"build-2784847793"},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>MEIS1::NCOA2<\/jats:italic>\n                    is a recurrent gene fusion that has been predominantly identified in primitive sarcomas arising within the genitourinary and gynecological tracts. Since its initial description in 2018, an increasing number of cases have been reported, further defining the clinicopathological spectrum of this entity. We report a case of an\n                    <jats:italic>MEIS1::NCOA2<\/jats:italic>\n                    \u2010rearranged low\u2010grade myxoid spindle cell neoplasm arising in the vulva of a 31\u2010year\u2010old female, presenting as a polypoid mass. Histologically, the lesion was composed predominantly of hypocellular spindle\u2010cell areas, with focal hypercellular and focal myxoid regions. Immunohistochemistry was nonspecific, demonstrating weak, variable expression of estrogen receptor (ER) and focal positivity for desmin, WT1, smooth muscle actin, and h\u2010caldesmon. RNA\u2010based next\u2010generation sequencing identified a\n                    <jats:italic>MEIS1::NCOA2<\/jats:italic>\n                    fusion transcript, which was subsequently confirmed by fluorescence in\u00a0situ hybridization (FISH), demonstrating\n                    <jats:italic>NCOA2<\/jats:italic>\n                    rearrangement. This case demonstrates remarkably bland, low\u2010grade cytological features and appears to represent the least cytologically atypical example of this neoplasm described to date. As such, it further extends the known morphological spectrum and contributes to our evolving understanding of this entity. Given the deceptively benign histological appearance and the absence of overt sarcomatous features, we favor the designation of \u201c\n                    <jats:italic>MEIS1::NCOA2\u2010<\/jats:italic>\n                    rearranged low\u2010grade myxoid spindle cell neoplasm\u201d rather than sarcoma.\n                  <\/jats:p>","DOI":"10.1002\/gcc.70164","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T04:11:47Z","timestamp":1787371907000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>MEIS1::NCOA2<\/i>\n                    Rearranged Spindle Cell Neoplasm of Vulva With Unusual Low\u2010Grade Morphology"],"prefix":"10.1002","volume":"65","author":[{"given":"Pinki","family":"Soni","sequence":"first","affiliation":[{"name":"Department of Pathology Monash Health  Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5245-3080","authenticated-orcid":false,"given":"Liyan","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Pathology Monash Health  Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Phung","sequence":"additional","affiliation":[{"name":"Department of Gynaecological Oncology Monash Health  Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Colebatch","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology RPA Hospital  Camperdown New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4444-0297","authenticated-orcid":false,"given":"John M.","family":"Gross","sequence":"additional","affiliation":[{"name":"Department of Pathology Johns Hopkins University School of Medicine  Baltimore Maryland USA"},{"name":"Department of Oncology Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8797-9474","authenticated-orcid":false,"given":"Pedram","family":"Argani","sequence":"additional","affiliation":[{"name":"Department of Pathology Johns Hopkins University School of Medicine  Baltimore Maryland USA"},{"name":"Department of Oncology Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7755-8745","authenticated-orcid":false,"given":"Pranav","family":"Dorwal","sequence":"additional","affiliation":[{"name":"Department of Pathology Monash Health  Clayton Victoria Australia"},{"name":"School of Clinical Sciences Monash University  Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001140"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379\u2010021\u201000744\u20107"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.14345"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.70164"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0000000000000951"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0000000000000803"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/10668969221098081"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13000\u2010024\u201001484\u20103"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0000000000000937"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428\u2010025\u201004079\u20105"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000002386"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0000000000000777"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13000\u2010025\u201001656\u20109"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics16132098"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr\u20102020\u2010236106"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0b013e31829cf432"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics12020357"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102559.2005.02063.x"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20937"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.21939"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.70153"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/10668969261439164"}],"container-title":["Genes, Chromosomes and Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gcc.70164","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/gcc.70164","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gcc.70164","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:25:52Z","timestamp":1787837152000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gcc.70164"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":22,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/gcc.70164"],"URL":"https:\/\/doi.org\/10.1002\/gcc.70164","archive":["Portico"],"relation":{},"ISSN":["1045-2257","1098-2264"],"issn-type":[{"value":"1045-2257","type":"print"},{"value":"1098-2264","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"2026-07-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70164"}}