{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:04:18Z","timestamp":1790255058136,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:00:00Z","timestamp":1789171200000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes Chromosomes &amp;amp; Cancer"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Head and neck carcinomas can be diagnostically challenging because of their diverse histologic subtypes. We report a case of a 55\u2010year\u2010old male presenting with right\u2010sided cervical adenopathy, in whom imaging revealed a cystic lesion that was subsequently confirmed to be metastatic from a lesion at the base of the tongue. Histological examination of the lesion at the base of the tongue demonstrated a biphasic tumor proliferation composed of nonkeratinized basaloid cells arranged in cohesive lobules, with focal small ductal structures. Immunohistochemistry highlighted the biphasic morphology, with strong nuclear expression of p40\/p63 in the abluminal cells and prominent membranous staining of CEA and CK7 in the luminal cells. Ancillary testing further characterized the lesion, identifying an HPV16 by DNA PCR. RNA sequencing revealed a\n                    <jats:italic>PARD3B::ERBB4<\/jats:italic>\n                    fusion involving\n                    <jats:italic>PARD3B<\/jats:italic>\n                    exon 13 and\n                    <jats:italic>ERBB4<\/jats:italic>\n                    exon 17, while targeted next\u2010generation sequencing identified a\n                    <jats:italic>KRAS<\/jats:italic>\n                    exon 2 c.35G&gt;A (p.Gly12Asp) mutation. Microdissection\u2010based analysis confirmed the same\n                    <jats:italic>KRAS<\/jats:italic>\n                    mutation in both the glandular and squamous components, supporting a shared clonal origin. This case highlights the clinicopathologic complexity of HPV\u2010associated adenosquamous carcinoma and expands the molecular spectrum of head and neck tumors through identification of a\n                    <jats:italic>PARD3B<\/jats:italic>\n                    ::\n                    <jats:italic>ERBB4<\/jats:italic>\n                    fusion.\n                  <\/jats:p>","DOI":"10.1002\/gcc.70165","type":"journal-article","created":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T15:10:41Z","timestamp":1789225841000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>HPV<\/scp>\n                    \u2010Associated Adenosquamous Carcinoma of the Oropharynx With a\n                    <scp>\n                      <i>PARD3B<\/i>\n                    <\/scp>\n                    ::\n                    <scp>\n                      <i>ERBB4<\/i>\n                    <\/scp>\n                    Fusion"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0535-0437","authenticated-orcid":false,"given":"Seddig","family":"Momenkhan","sequence":"first","affiliation":[{"name":"Service d'Anatomie et cytologie pathologiques Institut de Pathologie Multisite, Hospices Civils de Lyon, CHU Lyon Sud  Pierre\u2010B\u00e9nite France"},{"name":"Faculty of Medicine King Abdulaziz University  Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Blanc","sequence":"additional","affiliation":[{"name":"Service d'Oto\u2010Rhino\u2010Laryngologie et Chirurgie Cervico\u2010Faciale H\u00f4pital La Croix Rousse, Hospices Civils de Lyon  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1007-3265","authenticated-orcid":false,"given":"Pierre","family":"Philouze","sequence":"additional","affiliation":[{"name":"Service d'Oto\u2010Rhino\u2010Laryngologie et Chirurgie Cervico\u2010Faciale H\u00f4pital La Croix Rousse, Hospices Civils de Lyon  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Lopez","sequence":"additional","affiliation":[{"name":"Service de Biochimie et Biologie Mol\u00e9culaire, CHU Lyon Sud, Hospices Civils de Lyon Universit\u00e9 Claude Bernard Lyon I  Pierre\u2010B\u00e9nite France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francoise","family":"Descotes","sequence":"additional","affiliation":[{"name":"Service de Biochimie et Biologie Mol\u00e9culaire, CHU Lyon Sud, Hospices Civils de Lyon Universit\u00e9 Claude Bernard Lyon I  Pierre\u2010B\u00e9nite France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eudeline","family":"Alix","sequence":"additional","affiliation":[{"name":"Service d'Anatomie et cytologie pathologiques Institut de Pathologie Multisite, Hospices Civils de Lyon, CHU Lyon Sud  Pierre\u2010B\u00e9nite France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Leonce","sequence":"additional","affiliation":[{"name":"Service d\u2019Anatomie et cytologie pathologiques, Institut de Pathologie Multisite Hospices Civils de Lyon, CHU Lyon Est  Pierre\u2010B\u00e9nite France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5381-2836","authenticated-orcid":false,"given":"Ziyad","family":"Alsugair","sequence":"additional","affiliation":[{"name":"Service d'Anatomie et cytologie pathologiques Institut de Pathologie Multisite, Hospices Civils de Lyon, CHU Lyon Sud  Pierre\u2010B\u00e9nite France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazim","family":"Benzerdjeb","sequence":"additional","affiliation":[{"name":"Service d'Anatomie et cytologie pathologiques Institut de Pathologie Multisite, Hospices Civils de Lyon, CHU Lyon Sud  Pierre\u2010B\u00e9nite France"},{"name":"CICLY  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