{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:04:12Z","timestamp":1790255052143,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes Chromosomes &amp;amp; Cancer"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Pleomorphic liposarcoma (PLPS) is an aggressive high\u2010grade sarcoma that often shows diverse morphological features and can mimic high\u2010grade undifferentiated pleomorphic sarcoma (UPS)\/spindle cell sarcoma or myxofibrosarcoma (MFS), especially when pleomorphic lipoblasts are sparse. The molecular profile of PLPS is distinct from well differentiated\/dedifferentiated liposarcoma and myxoid liposarcoma. In this study, we investigate 39 cases of PLPS by comprehensive genomic profiling, occurring in 32 patients with available molecular data. Cases were reviewed and morphologic parameters\u2014lipoblastic component, UPS\u2010like, and MFS\u2010like areas were estimated. The genomic findings were collected and compared to UPS and MFS groups studied using the same platform. The cohort included 15 females and 17 males, with a median age of 56.5 (range, 34\u201378). The lower extremity (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200917) was the most common site involved, followed by upper extremity (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20095) and pelvis (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20095). UPS\u2010like and MFS\u2010like patterns were the most common morphologic variants, ranging from 15% to 95% and 20% to 90%, respectively.\n                    <jats:italic>TP53<\/jats:italic>\n                    (87%) and\n                    <jats:italic>RB1<\/jats:italic>\n                    (51%) mutations and copy number alterations were the most common alterations seen, followed by\n                    <jats:italic>ATRX<\/jats:italic>\n                    (36%). Compared to UPS and MFS,\n                    <jats:italic>TP53<\/jats:italic>\n                    and\n                    <jats:italic>RB1<\/jats:italic>\n                    gene alterations were significantly more common in PLPS. Conversely,\n                    <jats:italic>CDKN2A\/B<\/jats:italic>\n                    deletions were infrequent in PLPS. Survival analysis showed that\n                    <jats:italic>MYC<\/jats:italic>\n                    amplification was associated with significantly shorter overall survival in PLPS. Among histologic variants,\n                    <jats:italic>CYSLTR2<\/jats:italic>\n                    alterations were found to be highest in cases with predominantly pleomorphic lipoblasts; additionally, strong correlations were found between gene alteration frequencies of MFS and MFS\u2010like PLPS, and between UPS and UPS\u2010like PLPS.\n                    <jats:italic>RB1<\/jats:italic>\n                    allele\u2010specific copy number analysis showed loss of heterozygosity in 82% of cases. Our cohort of PLPS showed a complex molecular landscape with distinct genetic alterations, histologic correlations, and clinical outcomes, highlighting its unique position among genomically complex sarcomas and providing insights that may inform future diagnostic and therapeutic approaches.\n                  <\/jats:p>","DOI":"10.1002\/gcc.70166","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T11:35:21Z","timestamp":1788262521000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pleomorphic Liposarcoma: Comprehensive Genomic Analysis of 39 Cases With Comparison to Other Genomically Complex Sarcomas"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6400-660X","authenticated-orcid":false,"given":"Mohamed A.","family":"Yakoub","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4540-6990","authenticated-orcid":false,"given":"Carla","family":"Saoud","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7593-6052","authenticated-orcid":false,"given":"David","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Dickson","sequence":"additional","affiliation":[{"name":"Department of Medicine Memorial Sloan Kettering Cancer Center  New York New York USA"},{"name":"Department of Medicine Weill Cornell Medical College  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2965-752X","authenticated-orcid":false,"given":"Aimee M.","family":"Crago","sequence":"additional","affiliation":[{"name":"Department of Surgery Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2766-243X","authenticated-orcid":false,"given":"Meera","family":"Hameed","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6991-2310","authenticated-orcid":false,"given":"Narasimhan P.","family":"Agaram","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001962"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-021-02327-3"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2019.02.007"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181e5dc49"},{"key":"e_1_2_8_6_1","first-page":"43","volume-title":"Soft Tissue and Bone Tumours","author":"Folpe A. 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