{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:05:01Z","timestamp":1790255101750,"version":"4.1.0"},"reference-count":14,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes Chromosomes &amp;amp; Cancer"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Data on the clinicopathological features of\n                    <jats:italic>NRG1<\/jats:italic>\n                    fusion\u2010positive non\u2010small cell lung cancer (NSCLC) are limited. We conducted a retrospective, multicenter study and included patients with\n                    <jats:italic>NRG1<\/jats:italic>\n                    fusion\u2010positive NSCLC diagnosed between January 2018 and February 2025. Six patients were identified; five were female (83.3%), two were never\u2010smokers (33.3%), and four were former smokers (66.7%). Adenocarcinoma was the predominant histology (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20095), comprising mucinous (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20092), enteric (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20092), and not otherwise specified (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20091) variants, while one patient had squamous cell carcinoma. All were PD\u2010L1\u2013negative, and\n                    <jats:italic>CD74\u2010NRG1<\/jats:italic>\n                    was the most common fusion (50%). Three patients received afatinib; only one achieved a partial response with a progression\u2010free survival of 8.7\u2009months. Median overall survival was 6.7\u2009months. Our study demonstrates the histologic and molecular heterogeneity of\n                    <jats:italic>NRG1<\/jats:italic>\n                    fusion\u2010positive NSCLC, encompassing mucinous and enteric variants of adenocarcinoma. Responses to afatinib were variable, underscoring the need for more effective therapies, including zenocutuzumab and emerging agents.\n                  <\/jats:p>","DOI":"10.1002\/gcc.70170","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T03:40:01Z","timestamp":1788838801000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinicopathologic Features of\n                    <i>NRG1<\/i>\n                    Fusion\u2010Positive Non\u2010Small Cell Lung Cancer"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4462-6393","authenticated-orcid":false,"given":"Bahad\u0131r","family":"K\u00f6yl\u00fc","sequence":"first","affiliation":[{"name":"Division of Medical Oncology, Department of Internal Medicine Ko\u00e7 University School of Medicine  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0260-8568","authenticated-orcid":false,"given":"Nur \u0130layda","family":"Gen\u00e7","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Ko\u00e7 University School of Medicine  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6880-7204","authenticated-orcid":false,"given":"Mehmet Haluk","family":"Y\u00fccel","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Department of Internal Medicine Medipol University School of Medicine  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6402-4445","authenticated-orcid":false,"given":"An\u0131l","family":"Y\u0131ld\u0131z","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Ba\u015fak\u015fehir \u00c7am and Sakura City Hospital  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3030-2475","authenticated-orcid":false,"given":"Esra","family":"A\u015f\u0131k","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Department of Internal Medicine Karadeniz Technical University Faculty of Medicine  Trabzon T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8604-9988","authenticated-orcid":false,"given":"Cevat \u0130lteri\u015f","family":"K\u0131k\u0131l\u0131","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Department of Internal Medicine Ko\u00e7 University School of Medicine  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6085-1921","authenticated-orcid":false,"given":"Fatih","family":"Kemik","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Department of Internal Medicine Ko\u00e7 University School of Medicine  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2988-4450","authenticated-orcid":false,"given":"Nazan","family":"Demir","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Department of Internal Medicine Ko\u00e7 University School of Medicine  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5497-1513","authenticated-orcid":false,"given":"P\u0131nar","family":"Bulutay","sequence":"additional","affiliation":[{"name":"Department of Pathology Ko\u00e7 University School of Medicine  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7934-7039","authenticated-orcid":false,"given":"\u00d6mer Fatih","family":"\u00d6lmez","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Acibadem Maslak Hospital  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1273-1674","authenticated-orcid":false,"given":"Fatih","family":"Sel\u00e7ukbiricik","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Department of Internal Medicine Ko\u00e7 University School of Medicine  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.08.2335"},{"key":"e_1_2_11_3_1","first-page":"143","article-title":"NRG1 Fusions in NSCLC: Being eNRGy Conscious","volume":"15","author":"Gupta B.","year":"2024","journal-title":"Lung Cancer (Auckland, 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https:\/\/www.fda.gov\/drugs\/resources\u2010information\u2010approved\u2010drugs\/fda\u2010grants\u2010accelerated\u2010approval\u2010zenocutuzumab\u2010zbco\u2010non\u2010small\u2010cell\u2010lung\u2010cancer\u2010and\u2010pancreatic."},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2405008"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.21037\/pcm\u201023\u20102"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000008153"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-17-1004"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.esmoop.2025.105556"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2024.107469"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.esmoop.2025.104545"},{"key":"e_1_2_11_15_1","unstructured":"National Comprehensive Cancer Network \u201cNCCN Clinical Practice Guidelines in Oncology: Non\u2010Small Cell Lung Cancer \u201dVersion 6 (Plymouth Meeting PA National Comprehensive Cancer Network: 2026) https:\/\/www.nccn.org\/guidelines\/guidelines\u2010detail?category=1&id=1450."}],"container-title":["Genes, Chromosomes and 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