{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:50:05Z","timestamp":1792158605179,"version":"4.4.0"},"reference-count":23,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>This retrospective study involving 155 patients from the D\u00fcsseldorf MDS Registry compared cytogenetic banding from peripheral blood (PB) and bone marrow (BM) in patients with myelodysplastic syndromes (MDS) and chronic myelomonocytic leukemia (CMML). For 63 of these patients, paired PB and BM cytogenetic analyses were available that were conducted no more than 3\u2009months apart. Concordant ISCN results were found in 81%, with no significant differences in the total number of metaphases or aberrant metaphases between PB and BM. Furthermore, IPSS\u2010R\/\u2010M scorings, derived from PB and BM, turned out to be comparable, with only 7 out of 63 patients classified into a different cytogenetic risk category. This implies that aberrant clones are not underrepresented in PB and that cytogenetic findings from PB can reliably reflect those obtained from BM.<\/jats:p>","DOI":"10.1002\/gcc.70177","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:39:03Z","timestamp":1791549543000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Banding Karyotyping From Peripheral Blood Is a Useful Method for the Diagnostic Workup of Myelodysplastic Neoplasia and CMML"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-0478-9684","authenticated-orcid":false,"given":"Cornelia","family":"Heusler","sequence":"first","affiliation":[{"name":"Department of Hematology, Oncology and Clinical Immunology Heinrich\u2010Heine University  Duesseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Hildebrandt","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics, Heinrich\u2010Heine University  Duesseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felicitas","family":"Schulz","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology and Clinical Immunology Heinrich\u2010Heine University  Duesseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5893-2298","authenticated-orcid":false,"given":"Kathrin","family":"Nachtkamp","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology and Clinical Immunology Heinrich\u2010Heine University  Duesseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinna","family":"Strupp","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology and Clinical Immunology Heinrich\u2010Heine University  Duesseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Flatten","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology and Clinical Immunology Heinrich\u2010Heine University  Duesseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sascha","family":"Dietrich","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology and Clinical Immunology Heinrich\u2010Heine University  Duesseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Gattermann","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology and Clinical Immunology Heinrich\u2010Heine University  Duesseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Germing","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology and Clinical Immunology Heinrich\u2010Heine University  Duesseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,9]]},"reference":[{"issue":"9","key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1007\/s00277-008-0499-3","article-title":"Epidemiology, Classification and Prognosis of Adults and Children With Myelodysplastic Syndromes","volume":"87","author":"Germing U.","year":"2008","journal-title":"Annals of Hematology"},{"issue":"9","key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/j.leukres.2005.01.019","article-title":"Adequate Cytogenetic Examination in Myelodysplastic Syndromes: Analysis of 529 Patients","volume":"29","author":"Steidl C.","year":"2005","journal-title":"Leukemia Research"},{"issue":"13","key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"4385","DOI":"10.1182\/blood-2007-03-082404","article-title":"New Insights Into the Prognostic Impact of the Karyotype in MDS and Correlation With Subtypes: Evidence From a Core Dataset of 2124 Patients","volume":"110","author":"Haase D.","year":"2007","journal-title":"Blood"},{"issue":"12","key":"e_1_2_9_5_1","doi-asserted-by":"crossref","first-page":"2454","DOI":"10.1182\/blood-2012-03-420489","article-title":"Revised International Prognostic Scoring System for Myelodysplastic Syndromes","volume":"120","author":"Greenberg P. 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A Study on 153 Patients From a Single Institution","volume":"89","author":"Bernasconi P.","year":"2010","journal-title":"Annals of Hematology"},{"issue":"8","key":"e_1_2_9_22_1","doi-asserted-by":"crossref","first-page":"2906","DOI":"10.1182\/blood.V86.8.2906.2906","article-title":"Evidence for Malignant Transformation in Acute Myeloid Leukemia at the Level of Early Hematopoietic Stem Cells by Cytogenetic Analysis of CD34+ Subpopulations","volume":"86","author":"Haase D.","year":"1995","journal-title":"Blood"},{"issue":"6","key":"e_1_2_9_23_1","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1007\/s00277-017-2983-0","article-title":"Peripheral Blood Cytogenetics Allows Treatment Monitoring and Early Identification of Treatment Failure to Lenalidomide in MDS Patients: Results of the LE\u2010MON\u20105 Trial","volume":"96","author":"Braulke F.","year":"2017","journal-title":"Annals of Hematology"},{"key":"e_1_2_9_24_1","doi-asserted-by":"crossref","first-page":"106996","DOI":"10.1016\/j.leukres.2022.106996","article-title":"Cytogenetic Peripheral Blood Monitoring in Azacitidine Treated Patients With High\u2010Risk MDS\/sAML: A Monocentric Real\u2010World Experience","volume":"124","author":"Braulke F.","year":"2023","journal-title":"Leukemia Research"}],"container-title":["Genes, Chromosomes and Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gcc.70177","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/gcc.70177","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gcc.70177","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:12:18Z","timestamp":1792156338000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gcc.70177"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":23,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/gcc.70177"],"URL":"https:\/\/doi.org\/10.1002\/gcc.70177","archive":["Portico"],"relation":{},"ISSN":["1045-2257","1098-2264"],"issn-type":[{"value":"1045-2257","type":"print"},{"value":"1098-2264","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"2026-04-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70177"}}