{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T14:57:26Z","timestamp":1791471446826,"version":"4.3.4"},"reference-count":22,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005888","name":"Uniwersytet Medyczny w Lodzi","doi-asserted-by":"publisher","award":["503\/1\u2010034\u201003\/503\u201011\u2010001"],"award-info":[{"award-number":["503\/1\u2010034\u201003\/503\u201011\u2010001"]}],"id":[{"id":"10.13039\/501100005888","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes Chromosomes &amp;amp; Cancer"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Primary pericardial\n                    <jats:italic>SMARCB1<\/jats:italic>\n                    \u2010deficient tumors with rhabdoid morphology are exceptionally rare. We present an adult case of a primary\n                    <jats:italic>SMARCB1<\/jats:italic>\n                    \u2010deficient pericardial tumor showing concurrent loss of INI1 (\n                    <jats:italic>SMARCB1<\/jats:italic>\n                    ) and BRG1 (\n                    <jats:italic>SMARCA4<\/jats:italic>\n                    ) expression, representing the third documented tumor with co\u2010loss of these SWI\/SNF subunits across tumor sites. Targeted RNA sequencing detected no pathogenic sequence variants or fusion transcripts and showed reduced\n                    <jats:italic>SMARCB1<\/jats:italic>\n                    and\n                    <jats:italic>SMARCA4<\/jats:italic>\n                    transcript abundance. DNA\u2010based whole\u2010exome sequencing (WES) identified no pathogenic or likely pathogenic sequence variants in either gene. High\u2010resolution SNP microarray demonstrated a homozygous\n                    <jats:italic>SMARCB1<\/jats:italic>\n                    deletion with intact\n                    <jats:italic>SMARCA4<\/jats:italic>\n                    , establishing biallelic\n                    <jats:italic>SMARCB1<\/jats:italic>\n                    inactivation; BRG1 loss was accompanied by marked SMARCA4 transcript downregulation in the absence of a detectable SMARCA4 genomic alteration. In the clinicopathological context, the overall findings supported classification as a\n                    <jats:italic>SMARCB1<\/jats:italic>\n                    \u2010deficient pericardial tumor with rhabdoid morphology. Following resection, postoperative imaging suggested residual or recurrent disease. Combined doxorubicin\u2013ifosfamide chemotherapy and radical radiotherapy achieved a complete radiologic response. However, imaging 18\u2009months after resection suggested multifocal pericardial recurrence, with disease control regained following similar treatment. This course is hypothesis\u2010generating and may suggest sensitivity to DNA\u2010damaging therapy in the setting of dual SWI\/SNF deficiency.\n                  <\/jats:p>","DOI":"10.1002\/gcc.70179","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T14:25:16Z","timestamp":1791469516000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dual\n                    <scp>INI1<\/scp>\n                    \u2013\n                    <scp>BRG1<\/scp>\n                    \u2010Deficient Pericardial Tumor With Rhabdoid Morphology and Clinical Benefit From\n                    <scp>DNA<\/scp>\n                    \u2010Damaging Therapy"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-2212-1001","authenticated-orcid":false,"given":"Jakub","family":"Czerwi\u0144ski","sequence":"first","affiliation":[{"name":"Department of Pathology, Chair of Oncology Medical University of \u0141\u00f3d\u017a  \u0141\u00f3d\u017a Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6038-8842","authenticated-orcid":false,"given":"Karolina","family":"Miarka\u2010Walczyk","sequence":"additional","affiliation":[{"name":"Department of Genetic Predisposition to Cancer Medical University of \u0141\u00f3d\u017a  \u0141\u00f3d\u017a Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4810-6627","authenticated-orcid":false,"given":"Zuzanna","family":"Urba\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Genetic Predisposition to Cancer Medical University of \u0141\u00f3d\u017a  \u0141\u00f3d\u017a Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Hincz","sequence":"additional","affiliation":[{"name":"Department of Pathology, Chair of Oncology Medical University of \u0141\u00f3d\u017a  \u0141\u00f3d\u017a Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Marcinkiewicz","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Central Clinical Hospital Medical University of \u0141\u00f3d\u017a  \u0141\u00f3d\u017a Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Labuk","sequence":"additional","affiliation":[{"name":"Department of Pathology, Chair of Oncology Medical University of \u0141\u00f3d\u017a  \u0141\u00f3d\u017a Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2746-1662","authenticated-orcid":false,"given":"Rafa\u0142","family":"Czy\u017cykowski","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology, Central Clinical Hospital Medical University of \u0141\u00f3d\u017a  \u0141\u00f3d\u017a Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agata","family":"Pastorczak","sequence":"additional","affiliation":[{"name":"Department of Genetic Predisposition to Cancer Medical University of \u0141\u00f3d\u017a  \u0141\u00f3d\u017a Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3804-7042","authenticated-orcid":false,"given":"Marcin","family":"Braun","sequence":"additional","affiliation":[{"name":"Department of Pathology, Chair of Oncology Medical University of \u0141\u00f3d\u017a  \u0141\u00f3d\u017a 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