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In this review the ways in which nanoparticles can contain and rapidly diagnose COVID\u201019 under the umbrella of nanotheranostics (i.e., smart, single agents combining nanodiagnostics and nanotherapeutics) are elaborated. The present work provides new insights into the promising incorporation of antiviral nanotheranostics into nanostructured materials, including electrospun fibers with tailored pore sizes and hydrophobicity, namely \u201csuperhydrophobic self\u2010disinfecting electrospun facemasks\/fabrics (SSEF).\u201d SSEFs are proposed as smart alternatives to address the drawbacks of N95 respirators. The challenges of coronavirus containment are underscored, literature is reviewed, and \u201ctop\u2010five suggestions\u201d for containing COVID\u201019 are offered, including: i) preventive appraisals\u2014avoiding needless hospital admission and practicing frequent hand washing (from 20 to 60 s). ii) Diagnostics\u2014highly recommending nanodiagnostics, detecting COVID\u201019 within 10\u00a0min. iii) Therapeutics\u2014expanding nanotherapeutics to treat COVID\u201019 and bacterial co\u2010infections after safety assessments and clinical trials. iv) Multipronged and multinational, including China, collaborative appraisals. v) Humanitarian compassion to traverse this pandemic in a united way.<\/jats:p>","DOI":"10.1002\/gch2.202000112","type":"journal-article","created":{"date-parts":[[2021,3,25]],"date-time":"2021-03-25T06:59:37Z","timestamp":1616655577000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Could Nanotheranostics be the Answer to the Coronavirus Crisis?"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8616-4166","authenticated-orcid":false,"given":"Dina A.","family":"Mosselhy","sequence":"first","affiliation":[{"name":"Nanochemistry and Nanoengineering Department of Chemistry and Materials Science School of Chemical Engineering Aalto University  Espoo 02150 Finland"},{"name":"Department of Virology Faculty of Medicine University of Helsinki  P.O. Box 21 Helsinki 00014 Finland"},{"name":"Department of Veterinary Biosciences Faculty of Veterinary Medicine University of Helsinki  P.O. Box 66 Helsinki 00014 Finland"},{"name":"Microbiological Unit Fish Diseases Department Animal Health Research Institute  Dokki Giza 12618 Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mhd Adel","family":"Assad","sequence":"additional","affiliation":[{"name":"Nanochemistry and Nanoengineering Department of Chemistry and Materials Science School of Chemical Engineering Aalto University  Espoo 02150 Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarja","family":"Sironen","sequence":"additional","affiliation":[{"name":"Department of Virology Faculty of Medicine University of Helsinki  P.O. Box 21 Helsinki 00014 Finland"},{"name":"Department of Veterinary Biosciences Faculty of Veterinary Medicine University of Helsinki  P.O. Box 66 Helsinki 00014 Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mady","family":"Elbahri","sequence":"additional","affiliation":[{"name":"Nanochemistry and Nanoengineering Department of Chemistry and Materials Science School of Chemical Engineering Aalto University  Espoo 02150 Finland"},{"name":"Nanochemistry and Nanoengineering Institute for Materials Science Faculty of Engineering Kiel University  24143 Kiel Germany"},{"name":"Center for Nanotechnology Zewail City of Science and Technology  Sheikh Zayed District Giza 12588 Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,3,24]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2016.03.003"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-017-3144-z"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0900212"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1118391"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1085953"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsr1408795"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2001017"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30600-0"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30211-7"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1601896"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.1585"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2020.0980"},{"key":"e_1_2_9_13_1","unstructured":"Vital Surveillances China CDCWeekly2020 2 113."},{"key":"e_1_2_9_14_1","unstructured":"Morbidity and Mortality Weekly Report 2020 69 343."},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-0367-5"},{"key":"e_1_2_9_16_1","first-page":"E005","volume":"43","author":"Chen L.","year":"2020","journal-title":"Chin. 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