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Their potential for nanovaccines, immunoengineering, diagnosis, repurposing medication, and disinfectant surfaces targeting the novel coronavirus (SARS\u2010CoV\u20102) is highlighted. In this systematic review the aim is to present an unbiased view of which and how nanomaterials can reduce the spread of COVID\u201019. Herein, the focus is on SARS\u2010CoV\u20102, analyzing 46 articles retrieved before December 31, 2020. The interface between nanomaterials is described, and the main mechanisms to inhibit SARS\u2010CoV\u20102 pathogenesis and viral inactivation are also discussed. Nanocarbons, biopolymeric, copper, and silver nanoparticles are potential antiviral and virucidal agents toward self\u2010cleaning and reusable filter media and surfaces (e.g., facial masks), drug administration, vaccines, and immunodiagnostic assays. Trends in toxicology research and safety tests can help fill the main gaps in the literature and overcome health surveillance's challenges. Phytochemicals delivery by nanocarriers also stand out as candidates to target and bio\u2010friendly therapy. Nanocellulose might fill in the gaps. Future research using nanomaterials targeting novel therapies\/prophylaxis measures to COVID\u201019 and future outbreaks is discussed.<\/jats:p>","DOI":"10.1002\/gch2.202000115","type":"journal-article","created":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T09:20:02Z","timestamp":1613985602000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Recent Advances on Nanomaterials to COVID\u201019 Management: A Systematic Review on Antiviral\/Virucidal Agents and Mechanisms of SARS\u2010CoV\u20102 Inhibition\/Inactivation"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9258-5947","authenticated-orcid":false,"given":"Anna Paula A.","family":"Carvalho","sequence":"first","affiliation":[{"name":"COVID\u201019 Research Group Technological Development Support Laboratory (LADETEC) Department of Biochemistry Federal University of Rio de Janeiro (UFRJ)  UFRJ Rio de Janeiro 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