{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T14:26:19Z","timestamp":1789655179332,"version":"4.0.1"},"reference-count":278,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T00:00:00Z","timestamp":1682380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Global Challenges"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Dietary proteins derived from animal sources, although containing well\u2010balanced profiles of essential amino acids, have considerable environmental and adverse health effects associated with the intake of some animal protein\u2010based products. Consuming foods based on animal proteins carries a higher risk of developing non\u2010communicable diseases such as cancer, heart disease, non\u2010alcoholic fatty liver disease (NAFLD), and inflammatory bowel disease (IBD). Moreover, dietary protein consumption is increasing due to population growth, posing a supply challenge. There is, therefore, growing interest in discovering novel alternative protein sources. In this context, microalgae have been recognized as strategic crops that can provide a sustainable source of protein. Compared to conventional high\u2010protein crops, using microalgal biomass for protein production presents several advantages in food and feed in terms of productivity, sustainability, and nutritional value. Moreover, microalgae positively impact the environment by not exploiting land or causing water pollution. Many studies have revealed the potential of microalgae as an alternative protein source with the added value of positive effects on human health due to their anti\u2010inflammatory, antioxidant, and anti\u2010cancer properties. The main emphasis of this review is on the potential health\u2010promoting applications of microalgae\u2010based proteins, peptides, and bioactive substances for IBD and NAFLD.<\/jats:p>","DOI":"10.1002\/gch2.202200177","type":"journal-article","created":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T12:43:11Z","timestamp":1682426591000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":83,"title":["Microalgae\u2014Sustainable Source for Alternative Proteins and Functional Ingredients Promoting Gut and Liver Health"],"prefix":"10.1002","volume":"7","author":[{"given":"Yahav","family":"Eilam","sequence":"first","affiliation":[{"name":"Sphingolipids, Active Metabolites, and Immune Modulation Laboratory MIGAL \u2013 Galilee Research Institute  Tarshish 2 Kiryat Shemona North 1101600 Israel"},{"name":"Department of Biotechnology Tel Hai College  Upper Galilee North 1220800 Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamdan","family":"Khattib","sequence":"additional","affiliation":[{"name":"Sphingolipids, Active Metabolites, and Immune Modulation Laboratory MIGAL \u2013 Galilee Research Institute  Tarshish 2 Kiryat Shemona North 1101600 Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noam","family":"Pintel","sequence":"additional","affiliation":[{"name":"Sphingolipids, Active Metabolites, and Immune Modulation Laboratory MIGAL \u2013 Galilee Research Institute  Tarshish 2 Kiryat Shemona North 1101600 Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0444-881X","authenticated-orcid":false,"given":"Dorit","family":"Avni","sequence":"additional","affiliation":[{"name":"Sphingolipids, Active Metabolites, and Immune Modulation Laboratory MIGAL \u2013 Galilee Research Institute  Tarshish 2 Kiryat Shemona North 1101600 Israel"},{"name":"Department of Biotechnology Tel Hai College  Upper Galilee North 1220800 Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,25]]},"reference":[{"key":"e_1_2_10_1_1","author":"Benton T. G.","year":"2021","journal-title":"Energy, Environment and Resources Program"},{"key":"e_1_2_10_2_1","first-page":"463","volume":"597","author":"David A.","year":"2021","journal-title":"Nature"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1185383"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.appet.2020.105058"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43016-021-00225-9"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meatsci.2015.05.013"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods6050033"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.algal.2019.101540"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfpp.13940"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.10473"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods10061226"},{"key":"e_1_2_10_12_1","first-page":"5287","volume":"4","author":"Casadei E.","year":"2003","journal-title":"Food and Agriculture Organization Of The United Nation History and Purpose of the FAO"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2020.564413"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2021.772573"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2020.12.030"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2021.129697"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14194152"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14173533"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.5152\/tjg.2015.0106"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m2412"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep19032"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rser.2021.111549"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tifs.2022.06.016"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2019.108770"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-004-1647-x"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2013.05.001"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rser.2016.12.078"},{"key":"e_1_2_10_28_1","unstructured":"\u201cwww.algaebase.org.\u201dwww.algaebase.org(accessed Dec. 27 2022)."},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2019.07.011"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12092524"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aaf.2019.02.008"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10695-019-00621-w"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioelechem.2020.107588"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/app11093964"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/md17050304"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods11121744"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13111930"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jece.2022.107303"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2022.101932"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.01086"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10126-021-10020-z"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/3247528"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpn.12953"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2018.12.059"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2022.111338"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/2049-1891-4-27"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2021.101393"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbp.2018.02.002"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1080\/08905436.2019.1673171"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.3390\/md11103861"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1177\/039463201002300316"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf903089m"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/btpr.1769"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2012.04.022"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.procbio.2008.01.018"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11020201"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.3177\/jnsv.50.129"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.algal.2018.10.023"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2009.02.014"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.algal.2017.10.021"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/bit.26548"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods10123002"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00183-14"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2006.11.002"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomass2020006"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1093\/jaoac\/88.3.988"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.3390\/pr9091626"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.3390\/app12094402"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10811-012-9886-1"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.algal.2015.01.002"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.algal.2013.12.004"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2012.08.110"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.algal.2013.02.001"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2014.01.071"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0927-7757(00)00548-3"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40643-016-0094-8"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2012.01.001"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apenergy.2011.08.048"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2020.00469"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf020482t"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-59745-362-2_4"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1217501"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10068-011-0025-6"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiotec.2021.09.003"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclepro.2019.117821"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2012.12.038"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1080\/87559129.2016.1210632"},{"key":"e_1_2_10_88_1","first-page":"156","volume":"5","author":"Srinivasan D.","year":"2007","journal-title":"Fennema's Food Chemistry Fourth Edition."},{"key":"e_1_2_10_89_1","first-page":"1865","volume":"130","author":"Schaafsma G.","year":"2000","journal-title":"Criteria and Significance of Dietary Protein Sources in Humans The Protein Digestibility\u2010Corrected Amino Acid Score 1"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13205-017-0832-4"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.algal.2019.101617"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rser.2018.06.059"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0734-9750(02)00050-2"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00232-013-9542-y"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2020.122874"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2019.121870"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ifset.2013.11.009"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ifset.2021.102831"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfoodeng.2009.08.035"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods9111531"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2020.1768046"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.3390\/en6115921"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquaculture.2020.735310"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.algal.2018.07.013"},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2022.102705"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10126-022-10162-8"},{"key":"e_1_2_10_107_1","first-page":"1789","volume":"8","author":"Yang F.","year":"2014","journal-title":"Drug Des., Dev. Ther."},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.3390\/en12061166"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods10123078"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13113991"},{"key":"e_1_2_10_111_1","first-page":"590","volume-title":"Sustainable downstream processing of microalgae for Industrial Application","author":"Gayen K.","year":"2020"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.livsci.2017.09.020"},{"key":"e_1_2_10_113_1","volume-title":"Microalgae and Cyanobacteria as Green Molecular Factories: Tools and Perspectives","author":"Urtubia H. O.","year":"2016"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.1080\/07388550500248498"},{"key":"e_1_2_10_115_1","first-page":"341","volume":"12","author":"Skulberg O. M.","year":"2004","journal-title":"Microalgae as a source of bioactive molecules\u2010experience from cyanophyte research"},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-020-05562-9"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201000414"},{"key":"e_1_2_10_118_1","doi-asserted-by":"publisher","DOI":"10.3390\/md13106152"},{"key":"e_1_2_10_119_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008014424247"},{"key":"e_1_2_10_120_1","volume-title":"Algal culture\u202f: From laboratory to pilot plant","author":"Burlew J. S.","year":"1953"},{"key":"e_1_2_10_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2014.03.011"},{"key":"e_1_2_10_122_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.299.14.1690"},{"key":"e_1_2_10_123_1","doi-asserted-by":"publisher","DOI":"10.1002\/bit.25544"},{"key":"e_1_2_10_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2005.09.023"},{"key":"e_1_2_10_125_1","doi-asserted-by":"publisher","DOI":"10.3390\/md14050101"},{"key":"e_1_2_10_126_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9FO01742A"},{"key":"e_1_2_10_127_1","doi-asserted-by":"publisher","DOI":"10.3390\/md19070357"},{"key":"e_1_2_10_128_1","doi-asserted-by":"publisher","DOI":"10.3390\/md11010233"},{"key":"e_1_2_10_129_1","doi-asserted-by":"publisher","DOI":"10.3390\/md19100549"},{"key":"e_1_2_10_130_1","doi-asserted-by":"publisher","DOI":"10.1111\/1541-4337.12227"},{"key":"e_1_2_10_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2012.08.002"},{"key":"e_1_2_10_132_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-10007"},{"key":"e_1_2_10_133_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0409271102"},{"key":"e_1_2_10_134_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2017.9"},{"key":"e_1_2_10_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.01.001"},{"key":"e_1_2_10_136_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8FO02338G"},{"key":"e_1_2_10_137_1","doi-asserted-by":"publisher","DOI":"10.5402\/2012\/898153"},{"key":"e_1_2_10_138_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13051533"},{"key":"e_1_2_10_139_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-0156-2"},{"key":"e_1_2_10_140_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9010094"},{"key":"e_1_2_10_141_1","doi-asserted-by":"publisher","DOI":"10.1038\/embor.2013.27"},{"key":"e_1_2_10_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2019.11.003"},{"key":"e_1_2_10_143_1","doi-asserted-by":"publisher","DOI":"10.25122\/jml-2018-0075"},{"key":"e_1_2_10_144_1","first-page":"341","volume":"16","author":"Aebisher D. D.","year":"2018","journal-title":"Eur. J. Clin. Exp. Med."},{"key":"e_1_2_10_145_1","doi-asserted-by":"publisher","DOI":"10.1002\/biof.552210112"},{"key":"e_1_2_10_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-387669-0.00025-9"},{"key":"e_1_2_10_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2007.08.036"},{"key":"e_1_2_10_148_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-002-1006-8"},{"key":"e_1_2_10_149_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0601137103"},{"key":"e_1_2_10_150_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-28064-y"},{"key":"e_1_2_10_151_1","doi-asserted-by":"publisher","DOI":"10.1097\/CEJ.0b013e328351c69d"},{"key":"e_1_2_10_152_1","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.3815"},{"key":"e_1_2_10_153_1","first-page":"72","volume":"112","author":"Mccarty M. F.","year":"2015","journal-title":"Mo. Med."},{"key":"e_1_2_10_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2013.10.010"},{"key":"e_1_2_10_155_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1FO02970C"},{"key":"e_1_2_10_156_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.113.066381"},{"key":"e_1_2_10_157_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12029-012-9441-y"},{"key":"e_1_2_10_158_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114511006349"},{"key":"e_1_2_10_159_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-014-0745-5"},{"key":"e_1_2_10_160_1","doi-asserted-by":"publisher","DOI":"10.1097\/00054725-200311000-00005"},{"key":"e_1_2_10_161_1","first-page":"159","volume":"94","author":"Rumi G.","year":"2000","journal-title":"J. Physiol."},{"key":"e_1_2_10_162_1","doi-asserted-by":"publisher","DOI":"10.3109\/07388559109040622"},{"key":"e_1_2_10_163_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.772101"},{"key":"e_1_2_10_164_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-009-2420-y"},{"key":"e_1_2_10_165_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf802111x"},{"key":"e_1_2_10_166_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2005.02264.x"},{"key":"e_1_2_10_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5728(93)90235-Q"},{"key":"e_1_2_10_168_1","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevImmunol.v16.i3.30"},{"key":"e_1_2_10_169_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.021908.132657"},{"key":"e_1_2_10_170_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.7.4456"},{"key":"e_1_2_10_171_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.35.1_Suppl.S1"},{"key":"e_1_2_10_172_1","doi-asserted-by":"publisher","DOI":"10.1177\/014860719001400415"},{"key":"e_1_2_10_173_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(89)90406-X"},{"key":"e_1_2_10_174_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2016.08.003"},{"key":"e_1_2_10_175_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.02.024"},{"key":"e_1_2_10_176_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2016.08.002"},{"key":"e_1_2_10_177_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1237-9"},{"key":"e_1_2_10_178_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12294"},{"key":"e_1_2_10_179_1","doi-asserted-by":"publisher","DOI":"10.4103\/1319-3767.87177"},{"key":"e_1_2_10_180_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aap8914"},{"key":"e_1_2_10_181_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-021-11751-8"},{"key":"e_1_2_10_182_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.11.013"},{"key":"e_1_2_10_183_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2019.08.002"},{"key":"e_1_2_10_184_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i34.7727"},{"key":"e_1_2_10_185_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-018-0011-z"},{"key":"e_1_2_10_186_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2515"},{"key":"e_1_2_10_187_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00575"},{"key":"e_1_2_10_188_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40779-017-0122-9"},{"key":"e_1_2_10_189_1","doi-asserted-by":"publisher","DOI":"10.1006\/jsre.1993.1102"},{"key":"e_1_2_10_190_1","first-page":"231","volume":"4","author":"Mathias P.","year":"1993","journal-title":"Cell Biol."},{"key":"e_1_2_10_191_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.31.1.92"},{"key":"e_1_2_10_192_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199807000-00019"},{"key":"e_1_2_10_193_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.01388"},{"key":"e_1_2_10_194_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-019-0156-z"},{"key":"e_1_2_10_195_1","first-page":"364","volume":"13","author":"Tilo A.","year":"1991","journal-title":"Hepatology"},{"key":"e_1_2_10_196_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198902023200501"},{"key":"e_1_2_10_197_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2003.11.009"},{"key":"e_1_2_10_198_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840110110"},{"key":"e_1_2_10_199_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199701000-00013"},{"key":"e_1_2_10_200_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199208000-00002"},{"key":"e_1_2_10_201_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2672.1989.tb05105.x"},{"key":"e_1_2_10_202_1","doi-asserted-by":"publisher","DOI":"10.1079\/BJN2002532"},{"key":"e_1_2_10_203_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-1605(00)00398-6"},{"key":"e_1_2_10_204_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i21.3306"},{"key":"e_1_2_10_205_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2020.1802866"},{"key":"e_1_2_10_206_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.032805"},{"key":"e_1_2_10_207_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tifs.2022.09.012"},{"key":"e_1_2_10_208_1","doi-asserted-by":"publisher","DOI":"10.1071\/AN17272"},{"key":"e_1_2_10_209_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijfoodmicro.2010.10.007"},{"key":"e_1_2_10_210_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.01750"},{"key":"e_1_2_10_211_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.02.168"},{"key":"e_1_2_10_212_1","doi-asserted-by":"publisher","DOI":"10.1080\/09637486.2017.1309522"},{"key":"e_1_2_10_213_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodhyd.2018.05.016"},{"key":"e_1_2_10_214_1","first-page":"160","volume":"4","author":"Bhowmik D.","year":"2009","journal-title":"World J. Dairy Food Sci."},{"key":"e_1_2_10_215_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.15489"},{"key":"e_1_2_10_216_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2021.110880"},{"key":"e_1_2_10_217_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods10010037"},{"key":"e_1_2_10_218_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2020.104169"},{"key":"e_1_2_10_219_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00217-012-1798-4"},{"key":"e_1_2_10_220_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10811-012-9869-2"},{"key":"e_1_2_10_221_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.6b03931"},{"key":"e_1_2_10_222_1","doi-asserted-by":"publisher","DOI":"10.3390\/md18030166"},{"key":"e_1_2_10_223_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2015.05.015"},{"key":"e_1_2_10_224_1","first-page":"17","volume":"1","author":"Hirsova P.","year":"2015","journal-title":"CMGH"},{"key":"e_1_2_10_225_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.07.056"},{"key":"e_1_2_10_226_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27332"},{"key":"e_1_2_10_227_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1562942"},{"key":"e_1_2_10_228_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-013-9468-6"},{"key":"e_1_2_10_229_1","doi-asserted-by":"publisher","DOI":"10.1111\/tri.12707"},{"key":"e_1_2_10_230_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31820e82a1"},{"key":"e_1_2_10_231_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.12.025"},{"key":"e_1_2_10_232_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms15058591"},{"key":"e_1_2_10_233_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22306"},{"key":"e_1_2_10_234_1","first-page":"1","volume":"10","author":"Xu T.","year":"2018","journal-title":"Int. J. Physiol., Pathophysiol. Pharmacol."},{"key":"e_1_2_10_235_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12315"},{"key":"e_1_2_10_236_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1001976"},{"key":"e_1_2_10_237_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.05.033"},{"key":"e_1_2_10_238_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26267"},{"key":"e_1_2_10_239_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0084-1"},{"key":"e_1_2_10_240_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2015.07.008"},{"key":"e_1_2_10_241_1","doi-asserted-by":"publisher","DOI":"10.3390\/md9101840"},{"key":"e_1_2_10_242_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389203033487216"},{"key":"e_1_2_10_243_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2016.07.004"},{"key":"e_1_2_10_244_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu7042771"},{"key":"e_1_2_10_245_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13020430"},{"key":"e_1_2_10_246_1","doi-asserted-by":"publisher","DOI":"10.3746\/pnf.2013.18.2.124"},{"key":"e_1_2_10_247_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2020.04.001"},{"key":"e_1_2_10_248_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2010.05.006"},{"key":"e_1_2_10_249_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13113937"},{"key":"e_1_2_10_250_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13062017"},{"key":"e_1_2_10_251_1","doi-asserted-by":"publisher","DOI":"10.3390\/md13085402"},{"key":"e_1_2_10_252_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12571-015-0441-1"},{"key":"e_1_2_10_253_1","doi-asserted-by":"publisher","DOI":"10.3390\/fermentation3040059"},{"key":"e_1_2_10_254_1","doi-asserted-by":"publisher","DOI":"10.1016\/0144-4565(86)90021-1"},{"key":"e_1_2_10_255_1","first-page":"127","volume":"57","author":"Viscaa A.","year":"2017","journal-title":"Chem. Eng. Trans."},{"key":"e_1_2_10_256_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.algal.2017.11.038"},{"key":"e_1_2_10_257_1","doi-asserted-by":"publisher","DOI":"10.5772\/intechopen.89324"},{"key":"e_1_2_10_258_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.algal.2021.102433"},{"key":"e_1_2_10_259_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00449-017-1755-5"},{"key":"e_1_2_10_260_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.iecr.6b04814"},{"key":"e_1_2_10_261_1","doi-asserted-by":"publisher","DOI":"10.3390\/app9112377"},{"key":"e_1_2_10_262_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmars.2020.626389"},{"key":"e_1_2_10_263_1","unstructured":"\u201cRegulation (EU) 2015\/2283 of the European Parliament and of the Council of 25 November 2015 on novel foods amending Regulation (EU) No 1169\/2011 of the European Parliament and of the Council and repealing Regulation (EC) No 258\/97 of the European Parliament and of the Council and Commission Regulation (EC) No 1852\/2001 (Text with EEA relevance).\u201dhttp:\/\/data.europa.eu\/eli\/reg\/2015\/2283\/oj(accessed: November 2022)."},{"key":"e_1_2_10_264_1","unstructured":"US Food and Drug Administration Federal Food Drug and Cosmetic Act (FD&C Act) [(accessed on 29 March 2021)]."},{"key":"e_1_2_10_265_1","unstructured":"US Food and Drug Administration Generally Recognized as Safe (GRAS) [(accessed on 29 March 2021)]."},{"key":"e_1_2_10_266_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods11131871"},{"key":"e_1_2_10_267_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2020.103919"},{"key":"e_1_2_10_268_1","unstructured":"\u201chttps:\/\/www.alliedmarketresearch.com\/press\u2010release\/algae\u2010products\u2010market.\u201d (accessed: August 2022)."},{"key":"e_1_2_10_269_1","unstructured":"\u201chttps:\/\/www.grandviewresearch.com\/press\u2010release\/global\u2010algae\u2010protein\u2010market.\u201d (accessed: August 2022)."},{"key":"e_1_2_10_270_1","doi-asserted-by":"publisher","DOI":"10.1263\/jbb.101.87"},{"key":"e_1_2_10_271_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.algal.2014.09.002"},{"key":"e_1_2_10_272_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2019.07.022"},{"key":"e_1_2_10_273_1","first-page":"14","volume":"36","author":"Shetty A. M.","year":"2019","journal-title":"Federal Pratitioner"},{"key":"e_1_2_10_274_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjab029"},{"key":"e_1_2_10_275_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28785"},{"key":"e_1_2_10_276_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.794169"},{"key":"e_1_2_10_277_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00601"},{"key":"e_1_2_10_278_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2020.123362"}],"container-title":["Global Challenges"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gch2.202200177","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T01:57:12Z","timestamp":1692496632000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gch2.202200177"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,25]]},"references-count":278,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1002\/gch2.202200177"],"URL":"https:\/\/doi.org\/10.1002\/gch2.202200177","archive":["Portico"],"relation":{},"ISSN":["2056-6646","2056-6646"],"issn-type":[{"value":"2056-6646","type":"print"},{"value":"2056-6646","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,25]]},"assertion":[{"value":"2022-10-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2200177"}}