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Emerging evidence indicates that rising temperatures impair glucose homeostasis\u2014specifically through reduced brown adipose tissue activity and increased insulin resistance\u2014thereby exacerbating type 2 diabetes mellitus (T2DM) risk. Concurrently, food systems drive substantial greenhouse gas emissions (GHGE), with gender\u2010differentiated dietary patterns uniquely influencing both environmental impact and health outcomes. In this perspective, we move beyond well\u2010established separate links to propose an original integrated and systemic conceptual framework. This framework connects gender\u2010related drivers in dietary behaviors, GHGE, global warming, brown adipose tissue dysfunction, and T2DM risk into an integrated multidimensional feedback model, providing a novel basis to generate hypotheses for future mechanistic, epidemiological, and intervention studies, supporting gender\u2010sensitive prevention strategies.<\/jats:p>","DOI":"10.1002\/gch2.70140","type":"journal-article","created":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T06:29:39Z","timestamp":1792391379000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Global Warming and Type 2 Diabetes: Sex and Gender as Drivers in a Multidimensional Feedback Loop"],"prefix":"10.1002","volume":"10","author":[{"given":"Massimo","family":"D'Archivio","sequence":"first","affiliation":[{"name":"Gender\u2010Specific Prevention and Health Unit Centre For Gender\u2010Specific Medicine Istituto Superiore di Sanit\u00e0  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Zanchi","sequence":"additional","affiliation":[{"name":"Gender\u2010Specific Prevention and Health Unit Centre For Gender\u2010Specific Medicine Istituto Superiore di Sanit\u00e0  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Tammaro","sequence":"additional","affiliation":[{"name":"Gender\u2010Specific Prevention and Health Unit Centre For Gender\u2010Specific Medicine Istituto Superiore di Sanit\u00e0  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Masella","sequence":"additional","affiliation":[{"name":"Gender\u2010Specific Prevention and Health Unit Centre For Gender\u2010Specific Medicine Istituto Superiore di Sanit\u00e0  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2306-7043","authenticated-orcid":false,"given":"Claudia","family":"Cataldo","sequence":"additional","affiliation":[{"name":"Gender\u2010Specific Prevention and Health Unit Centre For Gender\u2010Specific Medicine Istituto Superiore di Sanit\u00e0  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,18]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"P. 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Atlanta (GA): CDC accessed 7 July 2025 https:\/\/www.cdc.gov\/diabetes\/articles\/managing\u2010diabetes\u2010in\u2010the\u2010heat.html."},{"issue":"5","key":"e_1_2_9_28_1","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1530\/EJE-18-0818","article-title":"Ambient Temperature and Prevalence of Diabetes and Insulin Resistance in the Spanish Population: Di@Bet.Es Study","volume":"180","author":"Vald\u00e9s S.","year":"2019","journal-title":"European Journal of Endocrinology"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/0265673021000058357"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JTHERBIO.2005.11.023"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2020.140994"},{"key":"e_1_2_9_32_1","unstructured":"Nancy Stedman.\u201cExtreme Heat and Cold Put People with Type 2 Diabetes at Risk for Dangerous Health Conditions. 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