{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T21:09:43Z","timestamp":1791148183624,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2002,1,8]],"date-time":"2002-01-08T00:00:00Z","timestamp":1010448000000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genesis"],"published-print":{"date-parts":[[2002,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Summary: Cerebellar deficient folia (<jats:italic>cdf<\/jats:italic>) is a recently identified mouse mutation causing ataxia and cerebellar abnormalities including lobulation defects and abnormal placement of a specific subset of Purkinje cells. To understand the etiology of the cerebellar defects in <jats:italic>cdf<\/jats:italic> mutant mice, we examined postnatal development of the <jats:italic>cdf\/cdf<\/jats:italic> cerebellum. Our results demonstrate that Purkinje cell ectopia and foliation defects are apparent at birth, suggesting the <jats:italic>cdf<\/jats:italic> mutation disrupts the positioning of many, but not all, Purkinje cells during development. In addition to cerebellar abnormalities, we observed lamination defects in the hippocampus of <jats:italic>cdf<\/jats:italic> mutant mice, although neocortical defects were not seen. Furthermore, ectopic Purkinje cells in <jats:italic>cdf\/cdf<\/jats:italic> mice express an increased level of Dab1 protein, as previously observed in mice with mutations in genes in the reelin signaling pathway. Lastly, analysis of <jats:italic>cdf<\/jats:italic> \u2194ROSA26 chimeric mice demonstrated that the <jats:italic>cdf<\/jats:italic> mutation is intrinsic to Purkinje cells. We suggest that the <jats:italic>cdf<\/jats:italic> gene product is required in a subset of Purkinje cells, possibly to respond to Reelin signals. genesis 32:32\u201341, 2002. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gene.10024","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T22:16:03Z","timestamp":1030313763000},"page":"32-41","source":"Crossref","is-referenced-by-count":21,"title":["The cerebellar deficient folia (<i>cdf<\/i><i>)<\/i> gene acts intrinsically in Purkinje cell migrations"],"prefix":"10.1002","volume":"32","author":[{"given":"Chankyu","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline H.","family":"Finger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan 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