{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T11:20:13Z","timestamp":1790162413193,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2002,5,8]],"date-time":"2002-05-08T00:00:00Z","timestamp":1020816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genesis"],"published-print":{"date-parts":[[2002,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Summary: While generating transgenic lines, transgene\u2010linked mutations can occur, which are caused by an insertional mutation at a given locus. More rarely, mutations unlinked to the transgene insertion site are observed. In the process of generating a mouse overexpressing the enzyme tyrosinase, we have obtained one transgenic line that appears to carry a semidominant insertional mutation at the <jats:italic>Gli3<\/jats:italic> (extra toes) locus, characterized by polydactyly and skeletal malformations. Additionally, the transgenic line contained a second mutation, <jats:italic>Crc (circletail),<\/jats:italic> which appears to be unlinked to the transgene insertion site. Heterozygous <jats:italic>Crc<\/jats:italic> mice are incompletely penetrant for a circled\u2010tail phenotype, while all homozygous <jats:italic>Crc\/Crc<\/jats:italic> mice die at birth of a severe neural tube defect (craniorachischisis). Anatomical evidence from a <jats:italic>Crc\/Crc; Gli3\/+<\/jats:italic> fetus indicates that these two genes may interact. genesis 33:55\u201361, 2002. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gene.10088","type":"journal-article","created":{"date-parts":[[2002,10,6]],"date-time":"2002-10-06T12:27:22Z","timestamp":1033907242000},"page":"55-61","source":"Crossref","is-referenced-by-count":16,"title":["A new allele of <i>Gli3<\/i> and a new mutation, <i>circletail (Crc),<\/i> resulting from a single transgenic experiment"],"prefix":"10.1002","volume":"33","author":[{"given":"Rivka A.","family":"Rachel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra J.","family":"Wellington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorothy","family":"Warburton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol A.","family":"Mason","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedrich","family":"Beermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,5,8]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1990.tb07470.x"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1242\/dev.123.1.129","article-title":"Mutations affecting development of the midline and general body shape during zebrafish embryogenesis","volume":"123","author":"Brand M","year":"1996","journal-title":"Development"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003359900527"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"3080","DOI":"10.1002\/j.1460-2075.1994.tb06607.x","article-title":"A cell\u2010specific enhancer far upstream of the mouse tyrosinase gene confers high level and copy number\u2010related expression in transgenic mice","volume":"13","author":"Ganss R","year":"1994","journal-title":"EMBO J"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.120.11.3119"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0393-241"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1994.1097"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000134207"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420070310"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.10.3709"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90034-V"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/359835a0"},{"key":"e_1_2_1_14_1","doi-asserted-by":"crossref","first-page":"3649","DOI":"10.1242\/dev.126.16.3649","article-title":"Ventral midline cells are required for the local control of commissural axon guidance in the mouse spinal cord","volume":"126","author":"Matise M","year":"1999","journal-title":"Development"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.23.11050"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.124.1.113"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.2001.6638"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-09-03363.1998"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/1526-968X(200005)27:1<32::AID-GENE50>3.0.CO;2-T"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.116.3.799"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00356157"}],"container-title":["genesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgene.10088","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gene.10088","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T12:55:24Z","timestamp":1700398524000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gene.10088"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,5,8]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2002,6]]}},"alternative-id":["10.1002\/gene.10088"],"URL":"https:\/\/doi.org\/10.1002\/gene.10088","archive":["Portico"],"relation":{},"ISSN":["1526-954X","1526-968X"],"issn-type":[{"value":"1526-954X","type":"print"},{"value":"1526-968X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,5,8]]}}}