{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T10:14:36Z","timestamp":1789380876718,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2002,10,25]],"date-time":"2002-10-25T00:00:00Z","timestamp":1035504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genesis"],"published-print":{"date-parts":[[2002,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Summary: Many kinases are required for progression through the eukaryotic cell cycle. The Aurora kinases comprise a highly conserved family of serine\/threonine kinases that have been implicated in chromosome segregation and cytokinesis in several organisms. We have isolated a sterile <jats:italic>Caenorhabditis elegans<\/jats:italic> mutant in which the majority of the locus encoding the Aurora A kinase <jats:italic>air\u20101<\/jats:italic> has been deleted. Complementation tests with previously isolated sterile mutations in the <jats:italic>air\u20101<\/jats:italic> genetic interval demonstrate that the <jats:italic>air\u20101<\/jats:italic> and <jats:italic>let\u2010412<\/jats:italic> loci are identical. Previous analysis of AIR\u20101 function by RNA\u2010mediated interference (RNAi) has shown that AIR\u20101 is required for embryonic survival. The characterization of the three sterile <jats:italic>air\u20101<\/jats:italic> mutant alleles described here extends these studies by revealing an allelic series that differentially affects postembryonic cell divisions and germline development. genesis 34:244\u2013250, 2002. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gene.10157","type":"journal-article","created":{"date-parts":[[2002,11,15]],"date-time":"2002-11-15T15:56:35Z","timestamp":1037375795000},"page":"244-250","source":"Crossref","is-referenced-by-count":11,"title":["<i>Caenorhabditis elegans<\/i> Aurora A kinase AIR\u20101 is required for postembryonic cell divisions and germline development"],"prefix":"10.1002","volume":"34","author":[{"given":"Tokiko","family":"Furuta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"Baillie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill M.","family":"Schumacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,10,25]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0962-8924(00)01880-8"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.126.10.2227"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/77.1.71"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/135.3.677"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.152.4.669"},{"issue":"21","key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"3591","DOI":"10.1242\/jcs.112.21.3591","article-title":"Aurora\/Ipl1p\u2010related kinases, a new oncogenic family of mitotic serine\u2010threonine kinases","volume":"112","author":"Giet R","year":"1999","journal-title":"J Cell Sci"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90374-7"},{"key":"e_1_2_1_9_1","first-page":"519","volume-title":"C. elegans II","author":"Greenwald I","year":"1997"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200108051"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/129.3.735"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.9.9.859"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/35048096"},{"key":"e_1_2_1_14_1","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1093\/genetics\/149.3.1303","article-title":"A genetic screen for temperature\u2010sensitive cell\u2010division mutants of Caenorhabditis elegans","volume":"149","author":"O'Connell KF","year":"1998","journal-title":"Genetics"},{"key":"e_1_2_1_15_1","doi-asserted-by":"crossref","first-page":"4371","DOI":"10.1242\/jcs.114.24.4371","article-title":"The S. pombe aurora\u2010related kinase Ark1 associates with mitotic structures in a stage dependent manner and is required for chromosome segregation","volume":"114","author":"Petersen J","year":"2001","journal-title":"J Cell Sci"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200110045"},{"key":"e_1_2_1_17_1","doi-asserted-by":"crossref","first-page":"4391","DOI":"10.1242\/dev.125.22.4391","article-title":"A highly conserved centrosomal kinase, AIR\u20101, is required for accurate cell cycle progression and segregation of developmental factors in Caenorhabditis elegans embryos","volume":"125","author":"Schumacher JM","year":"1998","journal-title":"Development"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.143.6.1635"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.3.667"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/131.3.609"}],"container-title":["genesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgene.10157","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gene.10157","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T19:26:54Z","timestamp":1696620414000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gene.10157"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,10,25]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2002,12]]}},"alternative-id":["10.1002\/gene.10157"],"URL":"https:\/\/doi.org\/10.1002\/gene.10157","archive":["Portico"],"relation":{},"ISSN":["1526-954X","1526-968X"],"issn-type":[{"value":"1526-954X","type":"print"},{"value":"1526-968X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,10,25]]}}}