{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T06:43:54Z","timestamp":1767854634965,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2001,5,8]],"date-time":"2001-05-08T00:00:00Z","timestamp":989280000000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genesis"],"published-print":{"date-parts":[[2001,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Summary: <jats:italic>Sry<\/jats:italic>, a single\u2010copy gene on the Y\u2010chromosome, triggers the fetal gonad to begin testis differentiation in mammals. On the other hand, mutation or absence of <jats:italic>Sry<\/jats:italic> results in ovary differentiation and the female phenotype. However, cases of XY sex reversal in the presence of wild\u2010type <jats:italic>Sry<\/jats:italic> exist in mice and man. One such example is the B6\u2010Y<jats:sup>TIR<\/jats:sup> mouse, whose autosomes and X\u2010chromosome are from the C57BL\/6J mouse (an inbred strain of <jats:italic>Mus musculus molossinus<\/jats:italic>), whereas the Y\u2010chromosome is from a <jats:italic>Mus musculus domesticus<\/jats:italic> mouse originating in Tirano, Italy. The B6\u2010Y<jats:sup>TIR<\/jats:sup> mouse never develops normal testes and instead develops ovaries or ovotestes in fetal life. It has been suggested that low levels of <jats:italic>Sry<\/jats:italic> transcription may account for the aberrant testis differentiation in the B6\u2010Y<jats:sup>TIR<\/jats:sup> mouse. In this study, however, we observed relatively low levels of <jats:italic>Sry<\/jats:italic> transcripts not only in B6\u2010Y<jats:sup>TIR<\/jats:sup> but also in B6 mice, which develop normal testes. We conclude that low dosage of <jats:italic>Sry<\/jats:italic> transcripts cannot be the sole cause of sex reversal in the B6\u2010Y<jats:sup>TIR<\/jats:sup> gonad. genesis 30:7\u201311, 2001. \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gene.1026","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T22:08:54Z","timestamp":1030313334000},"page":"7-11","source":"Crossref","is-referenced-by-count":20,"title":["Low levels of <i>Sry<\/i> transcripts cannot be the sole cause of B6\u2010Y<sup>TIR<\/sup> sex reversal"],"prefix":"10.1002","volume":"30","author":[{"given":"Chung\u2010Hae","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teruko","family":"Taketo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,5,8]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1093\/genetics\/147.3.1267","article-title":"DNA sequence analysis of Sry alleles (subgenus Mus) implicates misregulation as the cause of C57BL\/6J\u2010Ypos sex reversal and defines the SRY functional unit","volume":"147","author":"Albrecht KH","year":"1997","journal-title":"Genetics"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1994.1018"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/348448a0"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1139\/g88-140"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/11981"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1996.0156"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(87)90021-2"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0394-245"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.9.12.1645"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1995.0160"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1096-206"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7089579"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1995.1384"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/346245a0"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/351117a0"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1994.1266"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2563174"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1999.9436"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-0436.1987.tb01561.x"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.12.5355"},{"key":"e_1_2_1_22_1","volume-title":"Molecular cloning: A laboratory manual","author":"Sambrook J","year":"1989"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/346240a0"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1006\/abio.1994.1581"}],"container-title":["genesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgene.1026","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gene.1026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T17:16:34Z","timestamp":1700414194000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gene.1026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,5]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2001,5]]}},"alternative-id":["10.1002\/gene.1026"],"URL":"https:\/\/doi.org\/10.1002\/gene.1026","archive":["Portico"],"relation":{},"ISSN":["1526-954X","1526-968X"],"issn-type":[{"value":"1526-954X","type":"print"},{"value":"1526-968X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,5]]}}}