{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:21:45Z","timestamp":1790612505471,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2001,5,9]],"date-time":"2001-05-09T00:00:00Z","timestamp":989366400000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genesis"],"published-print":{"date-parts":[[2001,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Summary: A distinctive feature of gonadal maturation in mammals is the movement to an extraabdominal location. Testicular descent is a complex, multistage process whereby the embryonic gonads migrate from their initial abdominal position to the scrotum. Failure in this process results in cryptorchidism, a frequent congenital birth defect in humans. We report here a new mouse transgenic insertional mutation, cryptorchidism with white spotting (<jats:italic>crsp<\/jats:italic>). Males homozygous for <jats:italic>crsp<\/jats:italic> exhibit a high intraabdominal position of the testes, associated with complete sterility. Heterozygous males have a wild\u2010type phenotype, and homozygous females are fertile. Surgically descended testes in <jats:italic>crsp\/crsp<\/jats:italic> males show normal spermatogenesis. Using FISH and genetic analyses, the transgenic insert causing the <jats:italic>crsp<\/jats:italic> mutation has been mapped to the distal part of mouse chromosome 5. Transgene integration resulted in a 550\u2010kb deletion located upstream of the <jats:italic>Brca2<\/jats:italic> gene. A candidate gene encoding a novel G protein\u2010coupled receptor (<jats:italic>Great<\/jats:italic>) with an expression pattern suggesting involvement in testicular descent has been identified. genesis 30:26\u201335, 2001. \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gene.1029","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T22:08:54Z","timestamp":1030313334000},"page":"26-35","source":"Crossref","is-referenced-by-count":188,"title":["A transgenic insertion causing cryptorchidism in mice"],"prefix":"10.1002","volume":"30","author":[{"given":"Paul A.","family":"Overbeek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan P.","family":"Gorlov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard 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