{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T12:38:30Z","timestamp":1791031110557,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2001,7,3]],"date-time":"2001-07-03T00:00:00Z","timestamp":994118400000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genetic Epidemiology"],"published-print":{"date-parts":[[2001,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Plasma amyloid \u03b242 peptide (A\u03b242) levels are significantly elevated in all genetic forms of early\u2010onset Alzheimer\u2019s disease caused by familial Alzheimer\u2019s disease mutations or Down\u2019s syndrome. Moreover, recent studies have determined that both plasma A\u03b242 and A\u03b240 levels are significantly elevated in late\u2010onset Alzheimer\u2019s disease (LOAD) patients, their cognitively normal first\u2010degree relatives, and members of typical LOAD families when compared to appropriate controls. To determine the magnitude of the genetic component affecting plasma A\u03b2 levels, we estimated the heritability of plasma A\u03b242 and A\u03b240 in 15 extended, multigenerational LOAD pedigrees, using a variance components method. Heritability estimates as high as 73 and 54% were found for plasma A\u03b242 and A\u03b240 levels, respectively. Inclusion of the ApoE \u03f54 dosage as a covariate was not found to have a significant effect on the heritability of these traits. These results suggest that genetic determinants other than ApoE account for a very substantial percentage of the phenotypic variance in plasma A\u03b2 levels. The high heritability and the significant elevation of these traits in LOAD pedigrees suggest that at least some of the genetic determinants of plasma A\u03b2 levels may lead to elevated A\u03b2 and LOAD in these families. Thus, we suggest that plasma A\u03b2 levels are quantitative traits that may be excellent surrogate markers for use in linkage analysis to identify loci that are important in typical LOAD. Genet. Epidemiol. 21:19\u201330, 2001. \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gepi.1015","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T21:59:21Z","timestamp":1030312761000},"page":"19-30","source":"Crossref","is-referenced-by-count":39,"title":["Heritability of plasma amyloid \u03b2 in typical late\u2010onset Alzheimer\u2019s disease pedigrees"],"prefix":"10.1002","volume":"21","author":[{"given":"Nilufer","family":"Ertekin\u2010Taner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neill","family":"Graff\u2010Radford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda 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