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However, in principle, the kin\u2010cohort approach can be used in conjunction with a case\u2010control study in which family history data are carefully recorded to examine and validate the observed association of any candidate genotype with disease. Its utility for this purpose is governed by the relative efficiency of the kin\u2010cohort analysis to test hypotheses about the relevant genotype\u2010disease odds ratios, which in turn depends strongly on various factors, notably the magnitude of the disease incidence rate and the prevalence of the aberrant genotype. In this study, we compare the efficiencies of the two analytic approaches, case\u2010control vs. kin\u2010cohort, and illustrate the results in the context of cancer epidemiology. The kin\u2010cohort analysis can provide substantial, important supplementary information for relatively common cancers such as breast, lung, colorectal, and prostate, and is also relatively efficient in general for the evaluation of the stronger and more rare genetic risk factors. <jats:italic>Genet Epidemiol<\/jats:italic> 24:220\u2013229, 2003. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gepi.10235","type":"journal-article","created":{"date-parts":[[2003,3,19]],"date-time":"2003-03-19T11:59:29Z","timestamp":1048075169000},"page":"220-229","source":"Crossref","is-referenced-by-count":12,"title":["Kin\u2010cohort evaluation of relative risks of genetic variants"],"prefix":"10.1002","volume":"24","author":[{"given":"Catherine L.","family":"Saunders","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin B.","family":"Begg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,3,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.2307\/2532650"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2000.1407"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2272(200002)18:2<173::AID-GEPI6>3.0.CO;2-R"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/94.16.1221"},{"key":"e_1_2_1_6_1","first-page":"254","article-title":"The power of identity\u2010by\u2010state methods for linkage analysis","volume":"46","author":"Bishop DT","year":"1990","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19991130)18:22<3137::AID-SIM239>3.0.CO;2-O"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0006-341X.2001.00245.x"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.1022"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.18.10722"},{"key":"e_1_2_1_11_1","first-page":"506","article-title":"The validation of medical histories in kindreds","volume":"137","author":"Fusaro RM","year":"2001","journal-title":"Arch Dermatol"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2272(1999)16:1<15::AID-GEPI3>3.0.CO;2-8"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a116580"},{"key":"e_1_2_1_14_1","first-page":"741","article-title":"Population\u2010based estimate of the average age\u2010specific cumulative risk of breast cancer for a defined set of protein\u2010truncating mutations in BRCA1 and BRCA2","volume":"8","author":"Hopper JL","year":"1999","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jncimonographs.a024232"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.26265"},{"key":"e_1_2_1_17_1","first-page":"148","article-title":"The affected sib\u2010pair method using identity by state relations","volume":"39","author":"Lange K","year":"1986","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.2307\/2533854"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200007133430201"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600429"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.135.12.1527"},{"key":"e_1_2_1_22_1","unstructured":"RiesLAG EisnerMP KosaryCL HankeyBF MillerBA CleggL EdwardsBD editors. 1973\u20131999. 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