{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T10:26:46Z","timestamp":1760264806667},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,6,3]],"date-time":"2005-06-03T00:00:00Z","timestamp":1117756800000},"content-version":"vor","delay-in-days":7824,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genetic Epidemiology"],"published-print":{"date-parts":[[1984,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Segregation analysis favors a gene additive on liability with a frequency of 0.022, which is nearly recessive on the penetrance scale. Less than one\u2010eighth of DR3 and DR7 haplotypes carry a determinant for coeliac disease. There is significant excess of DR3\/7 heterozygotes among patients, indicating that the determinants are qualitatively different in DR3 and DR7 haplotypes. Linkage to HLA is highly significant (maximum lod score = 10.9). Evidence for recombination of 8% in males is attributed to residual errors in the model. We suggest an approach to a more precise model.<\/jats:p>","DOI":"10.1002\/gepi.1370010106","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T21:37:14Z","timestamp":1118525834000},"page":"37-42","source":"Crossref","is-referenced-by-count":12,"title":["Genetic epidemiology of coeliac disease"],"prefix":"10.1002","volume":"1","author":[{"given":"J. L.","family":"Tiwari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Betuel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Gebuhrer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. E.","family":"Morton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. C.","family":"Rao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,3]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"668","volume-title":"Histocompatibility Testing 1980","author":"Betuel H","year":"1980"},{"key":"e_1_2_1_3_1","first-page":"955","volume-title":"Histocompatibility Testing 1980","author":"Bauer MP","year":"1980"},{"key":"e_1_2_1_4_1","volume-title":"The Genetics of Coeliac Disease","author":"Ellis A","year":"1980"},{"key":"e_1_2_1_5_1","first-page":"477","volume-title":"Birth Defects Compendium","author":"Carter CO","year":"1979"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320120110"},{"key":"e_1_2_1_7_1","first-page":"263","article-title":"Evidence for recessive and against dominant inheritance at the HLA \u201clinked\u201d locus in coeliac disease","volume":"34","author":"Greenberg DA","year":"1982","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000153231"},{"key":"e_1_2_1_9_1","volume-title":"Mendelian Inheritance in Man\u2014Catalogs of Autosomal Dominant, Autosomal Recessive and X\u2010Linked Phenotypes","author":"McKusick VA","year":"1978"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000153168"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000153385"},{"key":"e_1_2_1_12_1","first-page":"201","article-title":"Heterozygous expression of IDDM determinants in the HLA system","volume":"35","author":"Morton NE","year":"1983","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_13_1","first-page":"507","article-title":"Les antigens HLA dans la maladie coeliaque et l'intolerance digestive aux proteines du lait de vache chez l'enfant","volume":"1","author":"Mougenot JF","year":"1977","journal-title":"Gastroenterol Clin Biol"},{"key":"e_1_2_1_14_1","first-page":"638","volume-title":"Histocom\u2010patibility Testing 1980","author":"Svejgaard A","year":"1980"}],"container-title":["Genetic Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgepi.1370010106","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gepi.1370010106","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T21:58:35Z","timestamp":1697752715000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gepi.1370010106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,1]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1984,1]]}},"alternative-id":["10.1002\/gepi.1370010106"],"URL":"https:\/\/doi.org\/10.1002\/gepi.1370010106","archive":["Portico"],"relation":{},"ISSN":["0741-0395","1098-2272"],"issn-type":[{"value":"0741-0395","type":"print"},{"value":"1098-2272","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,1]]}}}