{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T23:30:20Z","timestamp":1698017420442},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,6,3]],"date-time":"2005-06-03T00:00:00Z","timestamp":1117756800000},"content-version":"vor","delay-in-days":7824,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genetic Epidemiology"],"published-print":{"date-parts":[[1984,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We have been investigating cancer patterns in the Hutterites, a religious isolate residing on communal farms [Martin et al, 1980a,b,c]. Advantages of this population include extensive and accurate genealogies, essentially complete case ascertainment, and relatively uniform environmental background with regard to geographic location, lifestyle, and diet. However, application of the common epidemiological approach to familial risk assessment based on incidence in relatives of index cases [Haenszel, 1959] posed difficulties because all cases are probands. We also planned to employ matching to control for important confounders and thus had to deal with the problems of the matching of cases and controls as well as the existence of complex inbreeding [Hauck and Martin, 1982]. Our basic approach was to compare coefficients of kinship (F<jats:sub>m<\/jats:sub>, a measure of coancestry) of cases with each other to coefficients between cases and matched controls drawn from the same population. We have developed a paired t\u2010type statistic to assess the significance of observed differences.<\/jats:p><jats:p>We present, as examples, application of our methods to the analysis of Hutterite data on neurofibromatosis, known to be inherited in autosomal dominant fashion, and on cancer. Neurofibromatosis showed significant familial aggregation, as expected. Breast, colon\u2010rectal, and stomach cancer did not. We then show how to evaluate power and to determine appropriate sample sizes for detecting specified increases in kinship.<\/jats:p>","DOI":"10.1002\/gepi.1370010410","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T21:37:31Z","timestamp":1118525851000},"page":"383-400","source":"Crossref","is-referenced-by-count":6,"title":["A statistical test for detection of ancestral genetic contributions to disease occurrence in finite populations"],"prefix":"10.1002","volume":"1","author":[{"given":"Walter W.","family":"Hauck","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice O.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. C.","family":"Rao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,3]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1214\/aoms\/1177697287"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.bmb.a070672"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1214\/aos\/1176345462"},{"key":"e_1_2_1_5_1","first-page":"487","article-title":"Some problems in the estimation of familial risks of disease","volume":"23","author":"Haenszel W","year":"1959","journal-title":"J Natl Cancer Inst"},{"key":"e_1_2_1_6_1","first-page":"183A","article-title":"A statistical test for comparing kinship distributions of cases and controls","volume":"34","author":"Hauck WW","year":"1982","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_7_1","first-page":"299","volume-title":"Banbury Report 4: Cancer Incidence in Defined Populations","author":"Hill JR","year":"1980"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1214\/aoms\/1177730196"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.1330620106"},{"key":"e_1_2_1_10_1","volume-title":"Les Mathematiques de l'Heredite","author":"Mal\u00e9cot G","year":"1948"},{"key":"e_1_2_1_11_1","first-page":"317","article-title":"Identical loci and relationships","volume":"4","author":"Mal\u00e9cot G","year":"1967","journal-title":"Proc Fifth Berkeley Symp Math Statist Prob"},{"key":"e_1_2_1_12_1","first-page":"484","article-title":"Fortran programs for computing Wright's coefficient of inbreeding in human and nonhuman pedigrees","volume":"16","author":"Mange AP","year":"1964","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.1330320305"},{"key":"e_1_2_1_14_1","first-page":"1109","article-title":"Cancer mortality in a human isolate","volume":"65","author":"Martin AO","year":"1980","journal-title":"J Natl Cancer Inst"},{"key":"e_1_2_1_15_1","first-page":"235","volume-title":"Banbury Report 4: Cancer Incidence in Defined Populations","author":"Martin AO","year":"1980"},{"key":"e_1_2_1_16_1","first-page":"291","volume-title":"Genetic and Environmental Factors in Experimental and Human Cancer","author":"Martin AO","year":"1980"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.2307\/2334280"},{"key":"e_1_2_1_18_1","first-page":"43","volume-title":"Population Structure and Genetic Disorders","author":"Morton NE","year":"1980"},{"key":"e_1_2_1_19_1","first-page":"257","article-title":"The genetical background of common diseases","volume":"4","author":"Penrose LS","year":"1953","journal-title":"Acta Genet Stat Med"},{"key":"e_1_2_1_20_1","first-page":"175","article-title":"A familial aggregate of common variable immunodeficiency, Hodgkin disease and other malignancies in Newfoundland\u2014II. Genealogical analysis and conclusions regarding hereditary determinants","volume":"2","author":"Salmon D","year":"1980","journal-title":"Clin Invest Med"},{"key":"e_1_2_1_21_1","first-page":"477","volume-title":"Genes, Chromosomes and Neoplasia","author":"Skolnick M","year":"1981"},{"key":"e_1_2_1_22_1","first-page":"267","volume-title":"Proceedings of Third International Congress of Human Genetics","author":"Steinberg AG","year":"1967"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/hdy.1980.75"},{"key":"e_1_2_1_24_1","first-page":"614","article-title":"Bias and confidence in not quite large samples (abstract)","volume":"29","author":"Tukey J","year":"1958","journal-title":"Ann Math Statist"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.2307\/2529548"},{"key":"e_1_2_1_26_1","first-page":"711","volume-title":"Genetic Analysis of Common Diseases: Applications to Predictive Factors in Coronary Disease","author":"Williams RR","year":"1979"}],"container-title":["Genetic Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgepi.1370010410","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gepi.1370010410","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T09:26:00Z","timestamp":1697793960000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gepi.1370010410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,1]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1984,1]]}},"alternative-id":["10.1002\/gepi.1370010410"],"URL":"https:\/\/doi.org\/10.1002\/gepi.1370010410","archive":["Portico"],"relation":{},"ISSN":["0741-0395","1098-2272"],"issn-type":[{"value":"0741-0395","type":"print"},{"value":"1098-2272","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,1]]}}}