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Complex segregation analysis was employed using the mixed model with four parameters: major gene displacement (t), degree of dominance (d), gene frequency (q), and heritability (H). Heterogeneity was evident among the racial groups in the pattern of segregation of clubfoot. The most plausible genetic model is the presence of major gene effects with the multifactorial component for the Hawaiian and Caucasian groups, whereas no major gene action is evident for the Oriental group.<\/jats:p>","DOI":"10.1002\/gepi.1370040408","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T21:45:22Z","timestamp":1118526322000},"page":"299-306","source":"Crossref","is-referenced-by-count":31,"title":["A genetic analysis of clubfoot in Hawaii"],"prefix":"10.1002","volume":"4","author":[{"given":"Huiying","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chin S.","family":"Chung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert W.","family":"Nemechek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. 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