{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T16:16:16Z","timestamp":1758816976403},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,6,3]],"date-time":"2005-06-03T00:00:00Z","timestamp":1117756800000},"content-version":"vor","delay-in-days":6728,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genetic Epidemiology"],"published-print":{"date-parts":[[1987,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We performed hemoglobin electrophoresis in 30,400 apparently healthy black individuals in the Washington D.C. Metropolitan area, who were participating in a community based sickle\u2010cell screening program during the period 1978\u20131985. The overall prevalence of sickle\u2010cell trait was 6.7%. The frequency of sickle\u2010cell trait in various age groups, which included young children, adults, and individuals over 65 years of age, ranged from 6.4 to 7.4%. There were no statistically significant differences in the prevalence of sickle\u2010cell trait among the various age groups, nor did we detect a significant trend for increasing or decreasing sickle cell frequency with advancing age (P = 0.418). Thus, in this population sickle\u2010cell trait appears to have no effect on longevity. If the various complications of sickle\u2010cell trait reported in the literature are not fortuitous, their frequency and\/or severity must be too low to affect prevalence figures.<\/jats:p>","DOI":"10.1002\/gepi.1370040409","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T21:45:22Z","timestamp":1118526322000},"page":"307-311","source":"Crossref","is-referenced-by-count":18,"title":["Age and prevalence of sickle\u2010cell trait in a large ambulatory population"],"prefix":"10.1002","volume":"4","author":[{"given":"Oswaldo","family":"Castro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sohail R.","family":"Rana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ki Moon","family":"Bang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland B.","family":"Scott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. C.","family":"Rao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,3]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.2307\/3001775"},{"key":"e_1_2_1_3_1","first-page":"211","volume-title":"Wiley Series in Probability and Mathematical Statistics","author":"Brown BW","year":"1977"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.22.4.291"},{"key":"e_1_2_1_5_1","first-page":"358","article-title":"The sickle cell trait in relation to the training and assignment of duties in the armed forces: III. Hyposthenuria, hematuria, sudden death, rhabdomyolysis and acute tubular necrosis","volume":"55","author":"Diggs LW","year":"1984","journal-title":"Aviat Space Environ Med."},{"key":"e_1_2_1_6_1","first-page":"969","article-title":"A mobile unit as an adjunct to a community outreach program of education, screening and counseling for sickle cell disease, nutritional anemia and hypertension","volume":"74","author":"Duncan DE","year":"1982","journal-title":"J Nat Med Assoc."},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197905033001801"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1001\/jama.1983.03330300061037","article-title":"Severe metabolic complications in a cross\u2010country runner with sickle cell trait","volume":"249","author":"Helzlsouer KJ","year":"1983","journal-title":"JAMA."},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.2307\/4594926"},{"issue":"1","key":"e_1_2_1_10_1","first-page":"63a","article-title":"Sickle cell trait as a risk factor for sudden death in basic training (Abstract)","volume":"68","author":"Kark JA","year":"1986","journal-title":"Blood"},{"key":"e_1_2_1_11_1","first-page":"179","article-title":"Is sickle cell trait a health hazard? Medical problems: A brief review","volume":"4","author":"Knasel A","year":"1982","journal-title":"Am J Pediatr Hematol."},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1001\/jama.1985.03350390093033","article-title":"Splenic syndrome at mountain altitudes in sickle cell trait: Its occurrence in nonblack persons","volume":"253","author":"Lane PA","year":"1985","journal-title":"JAMA."},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ge.05.120171.000341"},{"key":"e_1_2_1_14_1","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1182\/blood.V54.5.961.961","article-title":"Genetics of red cells and susceptibility to malaria","volume":"54","author":"Luzzatto L","year":"1979","journal-title":"Blood."},{"key":"e_1_2_1_15_1","first-page":"381","article-title":"Multiple vascular infarction: A manifestation of sickle cell trait in the absence of hypoxia","volume":"63","author":"Magnuson TR","year":"1980","journal-title":"Minn Med."},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-198408000-00031"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(85)90289-3"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197004022821402"},{"key":"e_1_2_1_19_1","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1093\/milmed\/150.11.602","article-title":"Unexpected death in a Black military recruit with sickle cell trait: Case report","volume":"150","author":"Sateriale M","year":"1985","journal-title":"Milit Med."},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1979.03290370049028"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(78)90458-8"},{"key":"e_1_2_1_22_1","first-page":"49","volume-title":"Hemoglobin Variants in Human Populations","author":"Winter WP","year":"1986"}],"container-title":["Genetic Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgepi.1370040409","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gepi.1370040409","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T09:07:58Z","timestamp":1697879278000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gepi.1370040409"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,1]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1987,1]]}},"alternative-id":["10.1002\/gepi.1370040409"],"URL":"https:\/\/doi.org\/10.1002\/gepi.1370040409","archive":["Portico"],"relation":{},"ISSN":["0741-0395","1098-2272"],"issn-type":[{"value":"0741-0395","type":"print"},{"value":"1098-2272","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,1]]}}}