{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:13:48Z","timestamp":1761016428033},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,6,3]],"date-time":"2005-06-03T00:00:00Z","timestamp":1117756800000},"content-version":"vor","delay-in-days":6363,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genetic Epidemiology"],"published-print":{"date-parts":[[1988,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We examined the inheritance of juvenile myoclonic epilepsy (JME). We looked at both the trait of \u201cepilepsy\u201d and the trait of \u201cepilepsy\u2010plus\u2010EEG abnormalities\u201d, since EEG abnormalities are frequently found in the clinically unaffected sibs of JME patients. We tested several modes of inheritance including the fully penetrant recessive and several two\u2010locus models. We could reject all models tested (fully penetrant single\u2010locus and two\u2010locus models) when abnormal EEGs were classified as \u201cunaffected\u201d. We could also reject the fully penetrant single locus models when family members with abnormal EEGs were considered \u201caffected\u201d. We also rejected the two\u2010locus model where the inheritance at both loci was dominant. The two\u2010locus model where both loci showed recessive inheritance could not be rejected, nor could the model where one locus was dominant and the other recessive. Our results suggest that the underlying predisposition for JME is genetically determined and is partially reflected in the abnormal EEGs found in clinically unaffected family members.<\/jats:p>","DOI":"10.1002\/gepi.1370050204","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T21:47:58Z","timestamp":1118526478000},"page":"81-94","source":"Crossref","is-referenced-by-count":38,"title":["Segregation analysis of juvenile myoclonic epilepsy"],"prefix":"10.1002","volume":"5","author":[{"given":"David A.","family":"Greenberg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio V.","family":"Delgado\u2010Escueta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hector M.","family":"Maldonado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heidi","family":"Widelitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. C.","family":"Rao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. B.","family":"Borecki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,3]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"6A","volume-title":"Handbook of Electroencephalography and Clinical Neurophysiology","author":"Chatrian GE","year":"1976"},{"key":"e_1_2_1_3_1","first-page":"221","article-title":"Klinische\u2010elektroenzephalographische Untersuchungen bei Kindern von Epileptikern","volume":"47","author":"Christiani K","year":"1979","journal-title":"Fortschr Neurol Psychiatr"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.3.285"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1091777"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410160703"},{"key":"e_1_2_1_7_1","first-page":"519","article-title":"A simple method for testing two\u2010locus models of inheritance","volume":"33","author":"Greenberg DA","year":"1981","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_8_1","first-page":"167","article-title":"Simulation studies of segregation analysis: Application to two\u2010locus inheritance","volume":"36","author":"Greenberg DA","year":"1984","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_9_1","unstructured":"GreenbergDA Delgado\u2010EscuetaAV WidelitzH SparkesRS TreimanL MaldonadoHM ParkMS TerasakiPI(submitted):Juvenile myoclonic epilepsy may be linked to the HLA locus on human chromosome 6."},{"key":"e_1_2_1_10_1","volume-title":"Presented at Genetic Analysis Workshop V","author":"Greenberg DA","year":"1987"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320120110"},{"key":"e_1_2_1_12_1","volume-title":"Genetics of the Epilepsies","author":"Hodge SE"},{"key":"e_1_2_1_13_1","volume-title":"Genetics of the Epilepsies","author":"Janz D"},{"key":"e_1_2_1_14_1","first-page":"194","article-title":"EEG criteria for flying fitness applied by the German Air Force Institute of Aviation Medicine","volume":"46","author":"Oberholz H","year":"1975","journal-title":"Aviat Space Environ Med"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00282192"},{"key":"e_1_2_1_16_1","first-page":"165","article-title":"Methoden und Fehlerquellen der Untersuchung auf mendelische Zahlen beim Menschen","volume":"9","author":"Weinberg W","year":"1912","journal-title":"Arch Rassenbiol"}],"container-title":["Genetic Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgepi.1370050204","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gepi.1370050204","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T09:35:30Z","timestamp":1697967330000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gepi.1370050204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,1]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1988,1]]}},"alternative-id":["10.1002\/gepi.1370050204"],"URL":"https:\/\/doi.org\/10.1002\/gepi.1370050204","archive":["Portico"],"relation":{},"ISSN":["0741-0395","1098-2272"],"issn-type":[{"value":"0741-0395","type":"print"},{"value":"1098-2272","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,1]]}}}