{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T05:21:21Z","timestamp":1698124881780},"reference-count":14,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,6,7]],"date-time":"2005-06-07T00:00:00Z","timestamp":1118102400000},"content-version":"vor","delay-in-days":5271,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genetic Epidemiology"],"published-print":{"date-parts":[[1991,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hereditary hematologic disorders (HHD) have been reported in excess among infants and families of infants with congenital cardiovascular malformations (CCM) compared with controls, suggesting possible common pathogenetic mechanisms. It is plausible that hemodynamic changes during pregnancy associated with HHD could affect cardiac morphogenesis. To investigate whether offspring of women with selected HHD have an excess risk of CCM, the authors examined data from a nationwide birth defects monitoring program (BDMP) covering about 2.9 million births in the United States between 1982 and 1988. The system ascertains major birth defects diagnosed in the newborn period. An anonymous linkage procedure linked maternal obstetric records with newborn records using demographic, diagnostic, and geographic variables. A total of 1,239 mothers were identified with selected HHD (47 hereditary spherocytosis, 575 thalassemias, 310 sickle cell anemia, 88 other hereditary hemolytic anemias, 159 von Willebrand disease, and 60 other congenital coagulapathies). In all, 14 infants received a newborn discharge diagnosis of CCM (expected number based on population rates of CCM from the same hospitals and time period is 7.74; <jats:italic>P<\/jats:italic> = 0.0268). No single CCM entity accounted for this excess. In contrast, 8 infants had major non\u2010CCM defects (expected number 7.46; <jats:italic>P<\/jats:italic> = 0.466). These data suggest an excess risk of CCM among offspring of women with selected HHD. Further studies are needed to explore these findings and to evaluate the pathogenetic significance of this association.<\/jats:p>","DOI":"10.1002\/gepi.1370080608","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T21:54:52Z","timestamp":1118526892000},"page":"417-423","source":"Crossref","is-referenced-by-count":6,"title":["Are offspring of women with hereditary hematologic disorders at increased risk of congenital cardiovascular malformations?"],"prefix":"10.1002","volume":"8","author":[{"given":"Muin J.","family":"Khoury","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grady D.","family":"Waters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Louise","family":"Martin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larry D.","family":"Edmonds","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. P.","family":"Vogler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,7]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"795","volume-title":"Maternal\u2010Fetal Medicine: Principles and Practice","author":"Anderson HM","year":"1984"},{"key":"e_1_2_1_3_1","unstructured":"Centers for Disease Control(1988): \u201cCongenital Malformations \u201d Surveillance Report. Atlanta Georgia."},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1986.02140150043030"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-2305-1_1"},{"key":"e_1_2_1_6_1","unstructured":"Commission on ProfessionalandHospital Activities (CPHA)(1986): \u201cInternational Classification of Diseases 9th revision Clinical Modification.\u201d Ann Arbor MI."},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/10.3.247"},{"key":"e_1_2_1_8_1","first-page":"337","article-title":"Hematologic disorders and congenital cardiovascular malformations: Converging lines of research","volume":"15","author":"Ferencz C","year":"1984","journal-title":"J Med"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(89)90122-8"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.41.1.23"},{"key":"e_1_2_1_11_1","volume-title":"Smith's Recognizable Patterns of Human Malformation","author":"Jones KL","year":"1988"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02076347"},{"key":"e_1_2_1_13_1","unstructured":"RehbergKJ(1990):Evaluation of the CDC mother\/infant record linkage program. M.S. thesis University of Cincinati."},{"key":"e_1_2_1_14_1","first-page":"182","article-title":"Management of hemophilia A and B during surgical correction of transposition of the great arteries","volume":"52","author":"Roskos RR","year":"1983","journal-title":"Mayo Clin Proc"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320310208"}],"container-title":["Genetic Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgepi.1370080608","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gepi.1370080608","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T07:23:56Z","timestamp":1698045836000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gepi.1370080608"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,1]]},"references-count":14,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1991,1]]}},"alternative-id":["10.1002\/gepi.1370080608"],"URL":"https:\/\/doi.org\/10.1002\/gepi.1370080608","archive":["Portico"],"relation":{},"ISSN":["0741-0395","1098-2272"],"issn-type":[{"value":"0741-0395","type":"print"},{"value":"1098-2272","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,1]]}}}