{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T03:44:46Z","timestamp":1765079086170},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,6,6]],"date-time":"2005-06-06T00:00:00Z","timestamp":1118016000000},"content-version":"vor","delay-in-days":4539,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genetic Epidemiology"],"published-print":{"date-parts":[[1993,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aggregation of colon, endometrial, ovarian, and possibly breast cancers in families has been described as a \u201ccancer family syndrome\u201d (now called Lynch syndrome II). To determine if the familial clustering of these malignancies was more common in women with cancer than without, we analyzed data from the Iowa Women's Health Study (IWHS), a population\u2010based sample of 41,837 women aged 55\u201369 years. Self\u2010reported information was collected on history of colon, uterine, ovarian, and breast cancers in female first\u2010degree relatives. A family history of cancer of the breast (odds ratio [OR] = 1.4), colon (OR = 1.3), and uterus (OR = 1.3), but not ovary (OR = 1.2), was significantly more common among women with a personal history of any of these four cancers (all <jats:italic>P<\/jats:italic> &lt; 0.05); the pattern of the ORs suggested strongly that the clustering tended to be site\u2010specific. Age\u2010adjusted relative risks (RR) of incident colon cancer over 5 years of follow\u2010up (N = 237) were calculated with regard to family history. Colon cancer incidence was increased among women with a family history of breast (RR = l.3), uterine (RR = 1.4), colon (RR = l.5), and ovarian (RR = 1.3) cancers, although none of the risk estimates achieved statistical significance. RR was, however, significantly related to the number of different cancer sites reported among family members (<jats:italic>P<\/jats:italic><jats:sub>trend<\/jats:sub> = 0.008). These data on a representative sample of postmenopausal women suggest that family histories of colon, breast, uterine, and ovarian cancers are associated with an increased risk of cancer at the same site, but provide little support for the hypothesis that Lynch syndrome II is a non\u2010random occurrence. \u00a9 1993 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gepi.1370100404","type":"journal-article","created":{"date-parts":[[2005,6,12]],"date-time":"2005-06-12T01:36:34Z","timestamp":1118540194000},"page":"235-244","source":"Crossref","is-referenced-by-count":47,"title":["Familial clustering of colon, breast, uterine, and ovarian cancers as assessed by family history"],"prefix":"10.1002","volume":"10","author":[{"given":"Christine L.","family":"Nelson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas A.","family":"Sellers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen S.","family":"Rich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John D.","family":"Potter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul G.","family":"McGovern","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence H.","family":"Kushi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,6]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0277-5379(91)90506-9"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19800315)45:5 <1112::AID-CNCR2820451315>3.0.CO;2-9"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016349009028689"},{"key":"e_1_2_1_5_1","first-page":"82","volume-title":"Statistical Methods in Cancer Research: Vol II. The Design and Analysis of Cohort Studies","author":"Breslow NE","year":"1987"},{"key":"e_1_2_1_6_1","first-page":"711","article-title":"Determinants of ovarian cancer risk. I. Reproductive experiences and family history","volume":"71","author":"Cramer DW","year":"1983","journal-title":"J Natl Cancer Inst"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90186-I"},{"key":"e_1_2_1_8_1","first-page":"111","article-title":"Hereditary colon cancer syndromes","volume":"23","author":"Fitzgibbons RJ","year":"1991","journal-title":"Surg Ann"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-199007000-00011"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/18.2.361"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01744899"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800771216"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365529108996504"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pu.05.050184.000245"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800630103"},{"key":"e_1_2_1_16_1","first-page":"221","article-title":"Differential diagnosis of the cancer family syndrome","volume":"136","author":"Lynch HT","year":"1973","journal-title":"Surg Gynecol Obstet"},{"key":"e_1_2_1_17_1","first-page":"1","volume-title":"Genetic Epidemiology of Cancer","author":"Lynch HT","year":"1989"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19850815)56:4<934::AID-CNCR2820560439>3.0.CO;2-I"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19850815)56:4<939::AID-CNCR2820560440>3.0.CO;2-T"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(91)90093-A"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02049703"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(86)90928-5"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02604313"},{"key":"e_1_2_1_24_1","first-page":"4135","article-title":"Evidence supporting exclusion of the DCC gene and a portion of chromosome 18q as the locus for susceptibility of hereditary nonpolyposis colorectal carcinoma in five kindreds","volume":"51","author":"Peltomaki P","year":"1991","journal-title":"Cancer Res"},{"key":"e_1_2_1_25_1","first-page":"4530","article-title":"Evidence that the MCC\u2010APC gene region in 5q21 is not the site for susceptibility to hereditary nonpolyposis colorectal carcinoma","volume":"52","author":"Peltomaki P","year":"1992","journal-title":"Cancer Res"},{"key":"e_1_2_1_26_1","first-page":"109","article-title":"Familial breast cancer and the association with colonic carcinoma","volume":"15","author":"Phipps RF","year":"1989","journal-title":"Eur J Surg Oncol"},{"key":"e_1_2_1_27_1","first-page":"4344","article-title":"Familial aggregation of tumors in the 3\u2010year experience of a population\u2010based colorectal cancer registry","volume":"49","author":"De Leon M Ponz","year":"1989","journal-title":"Cancer Res"},{"key":"e_1_2_1_28_1","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1001\/jama.1992.03490120087033","article-title":"Reconciling the epidemiology, physiology, and molecular biology of colon cancer","volume":"268","author":"Potter JD","year":"1992","journal-title":"Jama"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(79)90012-2"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.1370050506"},{"key":"e_1_2_1_31_1","first-page":"521","article-title":"Evaluating genetic association among ovarian, breast, and endometrial cancer: Evidence for a breast\/ovarian cancer relationship","volume":"45","author":"Schildkraut JM","year":"1989","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_32_1","volume-title":"Genetics and Cancer in Man","author":"Schimke RN","year":"1978"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800781005"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198809013190901"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2565047"},{"key":"e_1_2_1_36_1","first-page":"42","article-title":"A genetic study of carcinoma of the large intestine","volume":"10","author":"Woolf CM","year":"1958","journal-title":"Am J Hum Genet"}],"container-title":["Genetic Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgepi.1370100404","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gepi.1370100404","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T20:44:52Z","timestamp":1698180292000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gepi.1370100404"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,1]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1993,1]]}},"alternative-id":["10.1002\/gepi.1370100404"],"URL":"https:\/\/doi.org\/10.1002\/gepi.1370100404","archive":["Portico"],"relation":{},"ISSN":["0741-0395","1098-2272"],"issn-type":[{"value":"0741-0395","type":"print"},{"value":"1098-2272","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,1]]}}}