{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T05:03:46Z","timestamp":1698296626022},"reference-count":11,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,6,3]],"date-time":"2005-06-03T00:00:00Z","timestamp":1117756800000},"content-version":"vor","delay-in-days":4536,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genetic Epidemiology"],"published-print":{"date-parts":[[1993,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We examined the three Alzheimer's disease (AD) family data sets for heterogeneity. Four markers that were represented in all three data sets were selected for analysis. Markers BCL3EcoR\u2010Mlu and D19S13\/TaqI were chosen for chromosome 19 and D21S13\/TaqI and D21S16\/XbaI for chromosome 21. Homogeneity testing was performed on the data by use of Morton's pre\u2010divided samples test (PS\u2010test) and Smith's admixture test (A\u2010test). The C\u2010test of MacLean et al. [1992] was also used to test for linkage in the presence of heterogeneity. Assuming homogeneity, there was significant evidence of linkage to AD for BCL3, D19S13, D21S16 in the Duke data set and D19S13, D21S16 in the Boston data set. C\u2010tests also provided evidence of linkage for BCL3 and D21S13 in the Duke data set, and D21S16 in the Boston data set. No evidence for heterogeneity <jats:italic>within<\/jats:italic> the data sets was found for any of the four markers using either the A\u2010test or the C\u2010test. For marker BCL3, PS\u2010tests found evidence of heterogeneity <jats:italic>between<\/jats:italic> the three data sets and <jats:italic>between<\/jats:italic> early\u2010 versus late\u2010onset families combined over all data sets. \u00a9 1993 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gepi.1370100619","type":"journal-article","created":{"date-parts":[[2005,6,12]],"date-time":"2005-06-12T02:15:43Z","timestamp":1118542543000},"page":"443-447","source":"Crossref","is-referenced-by-count":2,"title":["Heterogeneity testing for Alzheimer's disease within and between data sets"],"prefix":"10.1002","volume":"10","author":[{"given":"L. L.","family":"Miller","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. M.","family":"Ploughman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. L.","family":"Marazita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,3]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.38.2.207"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410150406"},{"key":"e_1_2_1_4_1","unstructured":"LangeK(1988):Documentation for Mendel version 2.3."},{"key":"e_1_2_1_5_1","first-page":"1259","article-title":"A new test for linkage in the presence of locus heterogeneity","volume":"50","author":"MacLean CJ","year":"1992","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1987.01800170019003"},{"key":"e_1_2_1_7_1","first-page":"80","article-title":"The detection and estimation of linkage between the genes for elliptocytosis and the Rh blood type","volume":"8","author":"Morton NE","year":"1956","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_8_1","unstructured":"OttJ(1990):Documentation to HOMOG programs (Turbo Pascal V5)."},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(88)90220-8"},{"key":"e_1_2_1_10_1","first-page":"1034","article-title":"Linkage studies in familial Alzheimer Disease: Evidence for chromosome 19 linkage","volume":"48","author":"Pericak\u2010Vance MA","year":"1991","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1963.tb00210.x"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/347194a0"}],"container-title":["Genetic Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgepi.1370100619","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gepi.1370100619","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T16:23:43Z","timestamp":1698251023000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gepi.1370100619"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,1]]},"references-count":11,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1993,1]]}},"alternative-id":["10.1002\/gepi.1370100619"],"URL":"https:\/\/doi.org\/10.1002\/gepi.1370100619","archive":["Portico"],"relation":{},"ISSN":["0741-0395","1098-2272"],"issn-type":[{"value":"0741-0395","type":"print"},{"value":"1098-2272","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,1]]}}}