{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T15:40:48Z","timestamp":1698334848206},"reference-count":6,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,6,4]],"date-time":"2005-06-04T00:00:00Z","timestamp":1117843200000},"content-version":"vor","delay-in-days":4537,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genetic Epidemiology"],"published-print":{"date-parts":[[1993,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Age of onset heterogeneity in Alzheimer's disease families was modelled by allowing for different liability classes for affected individuals according to their age of onset when calculating lod scores to chromosome 21 and chromosome 19 markers. Linkage to chromosome 21 was supported in the Boston data set, and the method of age correction did not greatly change the lod scores when only affected individuals were analyzed. The location of a gene on chromosome 19 for late age of onset illness was affected by the assumptions about early onset individuals. \u00a9 1993 Wiley\u2010Liss, Inc.<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#note1\" \/><jats:fn><jats:p>This article is a US Government work and, as such, is in the  public domain in the United States of America.<\/jats:p><\/jats:fn>\n<\/jats:p>","DOI":"10.1002\/gepi.1370100620","type":"journal-article","created":{"date-parts":[[2005,6,12]],"date-time":"2005-06-12T02:15:43Z","timestamp":1118542543000},"page":"449-454","source":"Crossref","is-referenced-by-count":3,"title":["Linkage of Alzheimer's disease to chromosome 21 and chromosome 19 markers: Effect of age of onset assumptions"],"prefix":"10.1002","volume":"10","author":[{"given":"L. R.","family":"Goldin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. S.","family":"Gershon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,4]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.40.3_Part_1.395"},{"key":"e_1_2_1_3_1","first-page":"283","article-title":"Strategies for characterizing highly polymorphic markers in human gene mapping","volume":"51","author":"Ott J","year":"1992","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_4_1","first-page":"1034","article-title":"Linkage studies in familial Alzheimer Disease: Evidence for chromosome 19 linkage","volume":"48","author":"Pericak\u2010Vance MA","year":"1991","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/347194a0"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1411576"},{"key":"e_1_2_1_7_1","first-page":"273","article-title":"Assessment of amyloid\u2010\u03b2\u2010protein precursor gene mutations in a large set of familial and sporadic Alzheimer disease cases","volume":"51","author":"Tanzi RE","year":"1992","journal-title":"Am J Hum Genet"}],"container-title":["Genetic Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgepi.1370100620","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gepi.1370100620","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T16:25:09Z","timestamp":1698251109000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gepi.1370100620"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,1]]},"references-count":6,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1993,1]]}},"alternative-id":["10.1002\/gepi.1370100620"],"URL":"https:\/\/doi.org\/10.1002\/gepi.1370100620","archive":["Portico"],"relation":{},"ISSN":["0741-0395","1098-2272"],"issn-type":[{"value":"0741-0395","type":"print"},{"value":"1098-2272","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,1]]}}}