{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T05:04:45Z","timestamp":1698296685045},"reference-count":6,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,6,5]],"date-time":"2005-06-05T00:00:00Z","timestamp":1117929600000},"content-version":"vor","delay-in-days":4538,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genetic Epidemiology"],"published-print":{"date-parts":[[1993,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We present two new approaches to the problem of genetic heterogeneity encountered in linkage analysis of familial Alzheimer's disease. We used two\u2010locus models to represent the possible existence of two disease genes while allowing for intrafamilial heterogeneity, and modeled the occurrence of the early onset form of the disease with epistasis. We developed a mixture model of heterogeneity where the early and late onset family types can be either linked to chromosome 19, 21, or unlinked, and where it is not necessary to arbitrarily preclassify a family into an early or late onset family type. \u00a9 1993 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gepi.1370100621","type":"journal-article","created":{"date-parts":[[2005,6,12]],"date-time":"2005-06-12T02:15:43Z","timestamp":1118542543000},"page":"455-459","source":"Crossref","is-referenced-by-count":1,"title":["Two new approaches toward linkage heterogeneity of FAD: Two\u2010locus models and age of onset as a discriminator"],"prefix":"10.1002","volume":"10","author":[{"given":"Chantal","family":"M\u00e9rette","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Lehner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jurg","family":"Ott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,5]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"a188","article-title":"Analysis of complex diseases under oligogenic models and intrafamilial heterogeneity by the LINKAGE programs","volume":"47","author":"Lathrop GM","year":"1990","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/comjnl\/7.4.308"},{"key":"e_1_2_1_4_1","first-page":"1034","article-title":"Linkage studies in familial Alzheimer disease: evidence for chromosome 19 linkage","volume":"48","author":"Pericak\u2010Vance MA","year":"1991","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1411576"},{"key":"e_1_2_1_6_1","unstructured":"SchorkNJ BoehnkeM TerwilligerJD OttJ(1993):Two trait locus linkage analysis: a powerful strategy for mapping complex genetic traits(submitted)."},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.1370090106"}],"container-title":["Genetic Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgepi.1370100621","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gepi.1370100621","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T16:25:12Z","timestamp":1698251112000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gepi.1370100621"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,1]]},"references-count":6,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1993,1]]}},"alternative-id":["10.1002\/gepi.1370100621"],"URL":"https:\/\/doi.org\/10.1002\/gepi.1370100621","archive":["Portico"],"relation":{},"ISSN":["0741-0395","1098-2272"],"issn-type":[{"value":"0741-0395","type":"print"},{"value":"1098-2272","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,1]]}}}