{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T16:29:33Z","timestamp":1772814573673,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,6,3]],"date-time":"2005-06-03T00:00:00Z","timestamp":1117756800000},"content-version":"vor","delay-in-days":3806,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genetic Epidemiology"],"published-print":{"date-parts":[[1995,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>An increased frequency of the apolipoprotein E type 4 allele (APOE\u20104) has previously been associated with both late\u2010onset sporadic and late\u2010onset familial Alzheimer disease (AD) [Strittmatter et al. (1993) <jats:italic>Proc Natl Acad Sci USA<\/jats:italic> 90:1977\u20131981; Saunders et al. (1993a) <jats:italic>Neurology<\/jats:italic> 43:1467\u20131472]. To further investigate this association we genotyped affected individuals from 92 separate AD pedigrees including both early\u2010 and late\u2010onset cases. An increased frequency of the APOE\u20104 allele was found only among the late\u2010onset cases, both familial and sporadic, confirming the earlier reports. In addition, age at onset was significantly decreased in the APOE\u20104 homozygotes (in late onset families) compared to either APOE\u20104 heterozygotes or individuals not carrying an APOE\u20104 allele. We also observed a significantly decreased frequency of the APOE\u20102 allele in both the early\u2010and late\u2010onset familial cases. These results strengthen the argument for a direct role of APOE in susceptibility to AD. \u00a9 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gepi.1370120108","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T22:01:15Z","timestamp":1118527275000},"page":"83-92","source":"Crossref","is-referenced-by-count":59,"title":["Apolipoprotein E4 allele and Alzheimer disease: Examination of Allelic association and effect on age at onset in both early\u2010and late\u2010onset cases"],"prefix":"10.1002","volume":"12","author":[{"given":"P. A.","family":"Locke","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. M.","family":"Conneally","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. E.","family":"Tanzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. F.","family":"Gusella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. L.","family":"Haines","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,3]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02619631"},{"key":"e_1_2_1_3_1","first-page":"22","article-title":"Allele frequency estimation from data on relatives","volume":"48","author":"Boehnke M","year":"1991","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_4_1","first-page":"1","volume-title":"Alzheimer's Disease: Advances in Clinical and Basic Research","author":"Corain B","year":"1993"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8346443"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0694-180"},{"key":"e_1_2_1_7_1","first-page":"1026","article-title":"Segregation analysis reveals evidence for a major gene in familial Alzheimer's disease","volume":"48","author":"Farrer LA","year":"1991","journal-title":"Am J Hum 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