{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T17:02:19Z","timestamp":1791046939716,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,6,3]],"date-time":"2005-06-03T00:00:00Z","timestamp":1117756800000},"content-version":"vor","delay-in-days":3806,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genetic Epidemiology"],"published-print":{"date-parts":[[1995,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A method is described for estimating excess relative risks of a disease from familial factors. Beginning with population\u2010based series of cases and controls, a cohort of each subject's relatives is formed and checked for disease against a population based registry. The disease experience of the cohort formed from each subject's relatives is summarized as a kinship\u2010weighted familial standardized incidence ratio (FSIR). The FSIR's are used as exposure estimates in conditional linear excess relative risk models, which may be used not only to screen for significant familial disease aggregations, but also to estimate relative risks, population attributable risks, and gene\u2010environment interactions. The method is demonstrated on 4083 breast cancer cases from Utah and a set of matched controls. \u00a91995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gepi.1370120306","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T22:02:09Z","timestamp":1118527329000},"page":"291-301","source":"Crossref","is-referenced-by-count":70,"title":["Method for calculating risk associated with family history of a disease"],"prefix":"10.1002","volume":"12","author":[{"given":"Richard A.","family":"Kerber","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,6,3]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"188","article-title":"Cutaneous malignant melanoma and familial dysplastic nevi:Evidence for autosomal dominance and pleiotropy","volume":"38","author":"Bale SJ","year":"1986","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/328614a0"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a114174"},{"key":"e_1_2_1_5_1","unstructured":"Cannon\u2010AlbrightLA BishopDT GoldgarC SkolnickMH(1991): Genetic predisposition to cancer.Important Adv Oncol39\u201355."},{"key":"e_1_2_1_6_1","first-page":"45","article-title":"A prospective study of reproductive, familial and socioeconomic risk factors for breast cancer using NHANES I data","volume":"104","author":"Carter CL","year":"1989","journal-title":"Public Health Rep"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90253-B"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-199007000-00011"},{"key":"e_1_2_1_9_1","first-page":"299","volume-title":"Cancer Incidence in Defined Populations","author":"Hill JR","year":"1980"},{"key":"e_1_2_1_10_1","volume-title":"Heredity in Breast Cancer: A Genetic and Clinical Study of Two Hundred Probands","author":"Jacobsen O","year":"1946"},{"issue":"3","key":"e_1_2_1_11_1","first-page":"417","article-title":"Genetic analysis of cancer in families","volume":"9","author":"King MC","year":"1990","journal-title":"Cancer Surv"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/329642a0"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-71-4-747"},{"key":"e_1_2_1_14_1","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1093\/jnci\/24.3.551","article-title":"Inheritance of cancer of the stomach and large intestine in man","volume":"24","author":"Macklin MT","year":"1969","journal-title":"J Natl Cancer Inst"},{"key":"e_1_2_1_15_1","volume-title":"Les Mathematiques de l'Heredite","author":"Malecot G","year":"1948"},{"key":"e_1_2_1_16_1","first-page":"277","article-title":"Sequential tests for the detection of linkage","volume":"7","author":"Morton NE","year":"1955","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_17_1","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1093\/oxfordjournals.aje.a115075","article-title":"Risk factors for breast cancer: Pooled results from three Italian case\u2010control studies","volume":"128","author":"Negri E","year":"1988","journal-title":"Am J Epidemiol"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.9.3044"},{"key":"e_1_2_1_19_1","volume-title":"Epicure: Generalized Regression Models for Epidemiologic Data","author":"Preston DL","year":"1990"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.1370050506"},{"key":"e_1_2_1_21_1","volume-title":"Genes, Chromosomes, and Neoplasia","author":"Skolnick M","year":"1981"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.2307\/2530149"}],"container-title":["Genetic Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgepi.1370120306","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gepi.1370120306","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T05:20:20Z","timestamp":1698297620000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gepi.1370120306"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,1]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1995,1]]}},"alternative-id":["10.1002\/gepi.1370120306"],"URL":"https:\/\/doi.org\/10.1002\/gepi.1370120306","archive":["Portico"],"relation":{},"ISSN":["0741-0395","1098-2272"],"issn-type":[{"value":"0741-0395","type":"print"},{"value":"1098-2272","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,1]]}}}