{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T23:52:56Z","timestamp":1791071576034,"version":"4.1.0"},"reference-count":12,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2017,7,28]],"date-time":"2017-07-28T00:00:00Z","timestamp":1501200000000},"content-version":"vor","delay-in-days":6052,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genetic Epidemiology"],"published-print":{"date-parts":[[2001,1]]},"abstract":"<jats:p>While numerous familial studies of asthma have identified several distinct chromosomal regions, no linkage studies have been performed taking into account the age of onset of disease. Here, we performed a genome\u2010wide scan to search for loci linked either to asthma or wheezing age of onset in a population of German asthmatic children by incorporating survival analysis techniques in the maximum\u2010likelihood\u2010binomial approach. In addition to several regions already reported in asthma, wheezing age of onset was found to be strongly linked to chromosome 6q24\u2013q25 (lod score = 3.56). Interestingly, this region contains some candidates genes such as the gene coding for the IFN\u2010\u03b3 receptor ligand\u2010binding chain. \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gepi.2001.21.s1.s168","type":"journal-article","created":{"date-parts":[[2017,7,28]],"date-time":"2017-07-28T08:45:01Z","timestamp":1501231501000},"source":"Crossref","is-referenced-by-count":6,"title":["An Autosome\u2010Wide Search for Loci Underlying Wheezing Age of Onset in German Asthmatic Children Identifies a New Region of Interest on 6q24\u2013q25"],"prefix":"10.1002","volume":"21","author":[{"given":"Alexandre","family":"Alca\u00efs","sequence":"first","affiliation":[{"name":"INSERM 0436 Facult\u00e9 Piti\u00e9-Salp\u00eatri\u00e8re, and Laboratory of Human Genetics of Infectious Diseases Facult\u00e9 Necker Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Plancoulaine","sequence":"additional","affiliation":[{"name":"INSERM 0436 Facult\u00e9 Piti\u00e9-Salp\u00eatri\u00e8re, and Laboratory of Human Genetics of Infectious Diseases Facult\u00e9 Necker Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Abel","sequence":"additional","affiliation":[{"name":"INSERM 0436 Facult\u00e9 Piti\u00e9-Salp\u00eatri\u00e8re, and Laboratory of Human Genetics of Infectious Diseases Facult\u00e9 Necker Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,28]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2272(1998)15:4<371::AID-GEPI4>3.0.CO;2-5"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/301958"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1466-9218.2000.00003.x"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2272(1999)17:2<102::AID-GEPI2>3.0.CO;2-6"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.1370170775"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/75.1.65"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/383247a0"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/380152a0"},{"key":"e_1_2_1_10_1","first-page":"439","article-title":"Complete multipoint sib-pair analysis of qualitative and quantitative traits","volume":"57","author":"Kruglyak L","year":"1995","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_11_1","volume-title":"SAS\/STAT User's Guide, Version 6.12","author":"S.A.S. 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