{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T13:20:55Z","timestamp":1767705655922},"reference-count":9,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,1,6]],"date-time":"2005-01-06T00:00:00Z","timestamp":1104969600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genetic Epidemiology"],"published-print":{"date-parts":[[2005,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Recently, testing for anticipation has received renewed interest. It is well known that standard statistical methods are inappropriate for this purpose due to problems of sampling bias. Few statistical tests have been proposed for comparing mean age of onset in affected parents with mean age of onset in affected children. All of them are difficult to compute and lack software to perform the tests. In this report, we formulate the problem in terms of symmetry tests. We propose a simple generalized paired <jats:italic>t<\/jats:italic>\u2010test and a Wilcoxon signed rank test to adjust for the bias caused by the right truncation of both the parent's and child's ages at onset. We also extend the generalized paired <jats:italic>t<\/jats:italic>\u2010test to a random effects model that enables analysis of correlated data from nuclear families, and could be further extended to larger family structures. We illustrate the approaches with an example of panic disorder. <jats:italic>Genet. Epidemiol<\/jats:italic>. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gepi.20057","type":"journal-article","created":{"date-parts":[[2005,1,6]],"date-time":"2005-01-06T17:48:14Z","timestamp":1105033694000},"page":"256-260","source":"Crossref","is-referenced-by-count":7,"title":["New simple tests for age\u2010at\u2010onset anticipation: Application to panic disorder"],"prefix":"10.1002","volume":"28","author":[{"given":"W.Y.","family":"Tsai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary A.","family":"Heiman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan E.","family":"Hodge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,3,9]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"139","article-title":"Genetic linkage study of panic: Clinical methodology and description of pedigrees","volume":"81","author":"Fyer AJ","year":"1999","journal-title":"Am J Med Genet (Neuropsychiatr Genet)"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00041444-199622000-00005"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00041444-199521000-00007"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2272(1997)14:6<1091::AID-GEPI88>3.0.CO;2-C"},{"key":"e_1_2_1_6_1","first-page":"1047","article-title":"Nonparametric estimation of marginal distributions under bivariate truncation with application to testing for age\u2010of\u2010onset anticipation","volume":"11","author":"Huang J","year":"2001","journal-title":"Stat Sinica"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19980328)81:2<139::AID-AJMG4>3.0.CO;2-R"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0006-341X.1999.00834.x"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/77.1.169"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1086\/301823"}],"container-title":["Genetic Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgepi.20057","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gepi.20057","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T21:13:19Z","timestamp":1696626799000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gepi.20057"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,3,9]]},"references-count":9,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,4]]}},"alternative-id":["10.1002\/gepi.20057"],"URL":"https:\/\/doi.org\/10.1002\/gepi.20057","archive":["Portico"],"relation":{},"ISSN":["0741-0395","1098-2272"],"issn-type":[{"value":"0741-0395","type":"print"},{"value":"1098-2272","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,3,9]]}}}