{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T11:40:10Z","timestamp":1772192410454,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,4,16]],"date-time":"2012-04-16T00:00:00Z","timestamp":1334534400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genetic Epidemiology"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:p>In a recent genome\u2010wide association study (<jats:styled-content style=\"fixed-case\">GWAS<\/jats:styled-content>) from an international consortium, evidence of linkage and association in chr8q24 was much stronger among nonsyndromic cleft lip\/palate (<jats:styled-content style=\"fixed-case\">CL<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>) case\u2010parent trios of <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>uropean ancestry than among trios of <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>sian ancestry. We examined marker information content and haplotype diversity across 13 recruitment sites (from <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>urope, <jats:styled-content style=\"fixed-case\">U<\/jats:styled-content>nited <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>tates, and <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>sia) separately, and conducted principal components analysis (<jats:styled-content style=\"fixed-case\">PCA<\/jats:styled-content>) on parents. As expected, <jats:styled-content style=\"fixed-case\">PCA<\/jats:styled-content> revealed large genetic distances between <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>uropeans and <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>sians, and a north\u2010south cline from <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>orea to <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>ingapore in <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>sia, with <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>ilipino parents forming a somewhat distinct <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>outheast <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>sian cluster. Hierarchical clustering of <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content> heterozygosity revealed two major clades consistent with <jats:styled-content style=\"fixed-case\">PCA<\/jats:styled-content> results. All genotyped <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s giving <jats:italic>P<\/jats:italic> &lt; 10<jats:sup>\u22126<\/jats:sup> in the allelic transmission disequilibrium test (<jats:styled-content style=\"fixed-case\">TDT<\/jats:styled-content>) showed higher heterozygosity in <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>uropeans than <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>sians. On average, <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>uropean ancestry parents had higher haplotype diversity than <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>sians. Imputing additional variants across chr8q24 increased the strength of statistical evidence among <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>uropeans and also revealed a significant signal among <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>sians (although it did not reach genome\u2010wide significance). Tests for <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>\u2010population interaction were negative, indicating the lack of strong signal for 8q24 in families of <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>sian ancestry was not due to any distinct genetic effect, but could simply reflect low power due to lower allele frequencies in <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>sians. Genet. Epidemiol. 36:392\u2013399, 2012. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/gepi.21633","type":"journal-article","created":{"date-parts":[[2012,4,16]],"date-time":"2012-04-16T17:09:56Z","timestamp":1334596196000},"page":"392-399","source":"Crossref","is-referenced-by-count":26,"title":["Examining Markers in 8q24 to Explain Differences in Evidence for Association With Cleft Lip With\/Without Cleft Palate Between <scp>A<\/scp>sians and <scp>E<\/scp>uropeans"],"prefix":"10.1002","volume":"36","author":[{"given":"Tanda","family":"Murray","sequence":"first","affiliation":[{"name":"Department of Epidemiology Johns Hopkins Bloomberg School of Public Health Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret A.","family":"Taub","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Johns Hopkins Bloomberg School of Public Health Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingo","family":"Ruczinski","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Johns Hopkins Bloomberg School of Public Health Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan F.","family":"Scott","sequence":"additional","affiliation":[{"name":"Institute of Genetic Medicine Johns Hopkins School of Medicine Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline B.","family":"Hetmanski","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Johns Hopkins Bloomberg School of Public Health Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holger","family":"Schwender","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Johns Hopkins Bloomberg School of Public Health Baltimore Maryland"},{"name":"Faculty of Statistics TU Dortmund University Dortmund Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Poorav","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Johns Hopkins Bloomberg School of Public Health Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian Xiao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Johns Hopkins Bloomberg School of Public Health Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald G.","family":"Munger","sequence":"additional","affiliation":[{"name":"Utah State University Logan Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allen J.","family":"Wilcox","sequence":"additional","affiliation":[{"name":"NIEHS\/NIH, Epidemiology Branch Durham North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqian","family":"Ye","sequence":"additional","affiliation":[{"name":"School of Stomatology Wuhan University Wuhan China"},{"name":"Department of Genetics &amp; Genomic Sciences Mount Sinai School of Medicine New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Wang","sequence":"additional","affiliation":[{"name":"Peking University Health Science Center Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Wu","sequence":"additional","affiliation":[{"name":"Peking University Health Science Center Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yah Huei","family":"Wu\u2010Chou","sequence":"additional","affiliation":[{"name":"Chang Gung Memorial Hospital Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Shi","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Disease West China College of Stomatology Sichuan University Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sun Ha","family":"Jee","sequence":"additional","affiliation":[{"name":"Department of Epidemiology &amp; Health Promotion Yonsei University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel","family":"Chong","sequence":"additional","affiliation":[{"name":"National University of Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Yeow","sequence":"additional","affiliation":[{"name":"KK Women's &amp; Children's Hospital Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey C.","family":"Murray","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Children's Hospital University of Iowa Iowa City Iowa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary L.","family":"Marazita","sequence":"additional","affiliation":[{"name":"Center for Craniofacial and Dental Genetics School of Dental Medicine University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terri H.","family":"Beaty","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Johns Hopkins Bloomberg School of Public Health Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,4,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0910668107"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.580"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwi132"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.333"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20659"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2009.01.005"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2008.149"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-294X.2006.03067.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09534"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2009.06.020"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1960"},{"key":"e_1_2_6_13_1","unstructured":"Illumina Technical Note.2010.The power of intelligentSNPselection. 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