{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T17:11:45Z","timestamp":1767892305226,"version":"3.49.0"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":579,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"University of Arkansas for Medical Sciences (UAMS)"},{"name":"National Institute on Drug Abuse under Award Number","award":["K01DA033346"],"award-info":[{"award-number":["K01DA033346"]}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental & Craniofacial Research","doi-asserted-by":"crossref","award":["R03DE022379"],"award-info":[{"award-number":["R03DE022379"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Korean Government","award":["NRF-2011-220-C00004"],"award-info":[{"award-number":["NRF-2011-220-C00004"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genet. Epidemiol."],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.1002\/gepi.21790","type":"journal-article","created":{"date-parts":[[2014,1,30]],"date-time":"2014-01-30T20:40:58Z","timestamp":1391114458000},"page":"242-253","source":"Crossref","is-referenced-by-count":13,"title":["A Generalized Genetic Random Field Method for the Genetic Association Analysis of Sequencing Data"],"prefix":"10.1002","volume":"38","author":[{"given":"Ming","family":"Li","sequence":"first","affiliation":[{"name":"Division of Biostatistics; Department of Pediatrics; University of Arkansas for Medical Sciences; Little Rock Arkansas United States of America"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zihuai","family":"He","sequence":"additional","affiliation":[{"name":"Department of Biostatistics; University of Michigan; Ann Arbor Michigan United States of America"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Biostatistics; University of Michigan; Ann Arbor Michigan United States of America"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaowei","family":"Zhan","sequence":"additional","affiliation":[{"name":"Department of Biostatistics; University of Michigan; Ann Arbor Michigan United States of America"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changshuai","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatics; Michigan State University; East Lansing Michigan United States of America"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert C.","family":"Elston","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics; Case Western Reserve University; Cleveland Ohio United States of America"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatics; Michigan State University; East Lansing Michigan United States of America"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,1,30]]},"reference":[{"key":"10.1002\/gepi.21790-BIB0001|gepi21790-cit-0001","doi-asserted-by":"crossref","DOI":"10.1137\/1.9780898718980","volume-title":"Random Fields and Geometry","author":"Adler","year":"2007"},{"issue":"Suppl 9","key":"10.1002\/gepi.21790-BIB0002|gepi21790-cit-0002","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1186\/1753-6561-5-S9-S2","article-title":"Genetic Analysis Workshop 17 mini-exome simulation","volume":"5","author":"Almasy","year":"2011","journal-title":"BMC Proc"},{"issue":"4","key":"10.1002\/gepi.21790-BIB0003|gepi21790-cit-0003","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.nbt.2008.12.009","article-title":"Next-generation DNA sequencing techniques","volume":"25","author":"Ansorge","year":"2009","journal-title":"N Biotechnol"},{"key":"10.1002\/gepi.21790-BIB0004|gepi21790-cit-0004","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/j.2517-6161.1986.tb01412.x","article-title":"Spatial interaction and statistical analysis of lattice systems","volume":"48","author":"Besag","year":"1974","journal-title":"J R Stat Soc B"},{"issue":"6","key":"10.1002\/gepi.21790-BIB0005|gepi21790-cit-0005","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/ng.f.136","article-title":"Common and rare variants in multifactorial susceptibility to common diseases","volume":"40","author":"Bodmer","year":"2008","journal-title":"Nat Genet"},{"key":"10.1002\/gepi.21790-BIB0006|gepi21790-cit-0006","doi-asserted-by":"crossref","first-page":"323","DOI":"10.2307\/2346911","article-title":"The distribution of a linear combination of Chi-square random variables","volume":"29","author":"Davies","year":"1980","journal-title":"Appl Stat"},{"issue":"6","key":"10.1002\/gepi.21790-BIB0007|gepi21790-cit-0007","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/nrg2809","article-title":"Missing heritability and strategies for finding the underlying causes of complex disease","volume":"11","author":"Eichler","year":"2010","journal-title":"Nat Rev Genet"},{"issue":"1","key":"10.1002\/gepi.21790-BIB0008|gepi21790-cit-0008","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1159\/000288704","article-title":"A data-adaptive sum test for disease association with multiple common or rare variants","volume":"70","author":"Han","year":"2010","journal-title":"Hum Hered"},{"key":"10.1002\/gepi.21790-BIB0009|gepi21790-cit-0009","unstructured":"He Z Zhang M Zhan X Lu Q 2013 Modeling and Testing for Joint Association Using a Genetic Random Field Model http:\/\/arxiv-web3.library.cornell.edu\/abs\/1302.5493eprintarXiv:1302.5493"},{"issue":"23","key":"10.1002\/gepi.21790-BIB0010|gepi21790-cit-0010","doi-asserted-by":"crossref","first-page":"9362","DOI":"10.1073\/pnas.0903103106","article-title":"Potential etiologic and functional implications of genome-wide association loci for human diseases and traits","volume":"106","author":"Hindorff","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"10.1002\/gepi.21790-BIB0011|gepi21790-cit-0011","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/ng.75","article-title":"Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans","volume":"40","author":"Kathiresan","year":"2008","journal-title":"Nat Genet"},{"issue":"11","key":"10.1002\/gepi.21790-BIB0012|gepi21790-cit-0012","doi-asserted-by":"crossref","first-page":"4943","DOI":"10.1210\/en.2005-0476","article-title":"Transgenic angiopoietin-like (angptl)4 overexpression and targeted disruption of angptl4 and angptl3: regulation of triglyceride metabolism","volume":"146","author":"Koster","year":"2005","journal-title":"Endocrinology"},{"issue":"2","key":"10.1002\/gepi.21790-BIB0013|gepi21790-cit-0013","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.ajhg.2007.10.010","article-title":"A powerful and flexible multilocus association test for quantitative traits","volume":"82","author":"Kwee","year":"2008","journal-title":"Am J Hum Genet"},{"issue":"2","key":"10.1002\/gepi.21790-BIB0014|gepi21790-cit-0014","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.ajhg.2012.06.007","article-title":"Optimal unified approach for rare-variant association testing with application to small-sample case-control whole-exome sequencing studies","volume":"91","author":"Lee","year":"2012","journal-title":"Am J Hum Genet"},{"issue":"3","key":"10.1002\/gepi.21790-BIB0015|gepi21790-cit-0015","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.ajhg.2008.06.024","article-title":"Methods for detecting associations with rare variants for common diseases: application to analysis of sequence data","volume":"83","author":"Li","year":"2008","journal-title":"Am J Hum Genet"},{"issue":"3","key":"10.1002\/gepi.21790-BIB0016|gepi21790-cit-0016","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.ajhg.2011.07.015","article-title":"A general framework for detecting disease associations with rare variants in sequencing studies","volume":"89","author":"Lin","year":"2011","journal-title":"Am J Hum Genet"},{"issue":"4","key":"10.1002\/gepi.21790-BIB0017|gepi21790-cit-0017","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1111\/j.1541-0420.2007.00799.x","article-title":"Semiparametric regression of multidimensional genetic pathway data: least-squares kernel machines and linear mixed models","volume":"63","author":"Liu","year":"2007","journal-title":"Biometrics"},{"issue":"4","key":"10.1002\/gepi.21790-BIB0018|gepi21790-cit-0018","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/gepi.21722","article-title":"A geometric framework for evaluating rare variant tests of association","volume":"37","author":"Liu","year":"2013","journal-title":"Genet Epidemiol"},{"issue":"2","key":"10.1002\/gepi.21790-BIB0019|gepi21790-cit-0019","doi-asserted-by":"crossref","first-page":"e1000384","DOI":"10.1371\/journal.pgen.1000384","article-title":"A groupwise association test for rare mutations using a weighted sum statistic","volume":"5","author":"Madsen","year":"2009","journal-title":"PLoS Genet"},{"issue":"7265","key":"10.1002\/gepi.21790-BIB0020|gepi21790-cit-0020","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/nature08494","article-title":"Finding the missing heritability of complex diseases","volume":"461","author":"Manolio","year":"2009","journal-title":"Nature"},{"issue":"2","key":"10.1002\/gepi.21790-BIB0021|gepi21790-cit-0021","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.cell.2010.03.032","article-title":"Genetic heterogeneity in human disease","volume":"141","author":"McClellan","year":"2010","journal-title":"Cell"},{"issue":"2","key":"10.1002\/gepi.21790-BIB0022|gepi21790-cit-0022","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1002\/gepi.20450","article-title":"An evaluation of statistical approaches to rare variant analysis in genetic association studies","volume":"34","author":"Morris","year":"2010","journal-title":"Genet Epidemiol"},{"issue":"6","key":"10.1002\/gepi.21790-BIB0023|gepi21790-cit-0023","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.ajhg.2010.04.005","article-title":"Pooled association tests for rare variants in exon-resequencing studies","volume":"86","author":"Price","year":"2010","journal-title":"Am J Hum Genet"},{"issue":"1","key":"10.1002\/gepi.21790-BIB0024|gepi21790-cit-0024","first-page":"70","article-title":"Rare loss-of-function mutations in ANGPTL family members contribute to plasma triglyceride levels in humans","volume":"119","author":"Romeo","year":"2009","journal-title":"J Clin Invest"},{"issue":"3","key":"10.1002\/gepi.21790-BIB0025|gepi21790-cit-0025","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.gde.2009.04.010","article-title":"Common vs. rare allele hypotheses for complex diseases","volume":"19","author":"Schork","year":"2009","journal-title":"Curr Opin Genet Dev"},{"issue":"1","key":"10.1002\/gepi.21790-BIB0026|gepi21790-cit-0026","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/nmeth1156","article-title":"Next-generation sequencing transforms today's biology","volume":"5","author":"Schuster","year":"2008","journal-title":"Nat Methods"},{"issue":"37","key":"10.1002\/gepi.21790-BIB0027|gepi21790-cit-0027","doi-asserted-by":"crossref","first-page":"33742","DOI":"10.1074\/jbc.M203215200","article-title":"ANGPTL3 decreases very low density lipoprotein triglyceride clearance by inhibition of lipoprotein lipase","volume":"277","author":"Shimizugawa","year":"2002","journal-title":"J Biol Chem"},{"issue":"3","key":"10.1002\/gepi.21790-BIB0028|gepi21790-cit-0028","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1111\/j.1541-0420.2008.01176.x","article-title":"Gene-trait similarity regression for multimarker-based association analysis","volume":"65","author":"Tzeng","year":"2009","journal-title":"Biometrics"},{"issue":"2","key":"10.1002\/gepi.21790-BIB0029|gepi21790-cit-0029","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.ajhg.2011.07.007","article-title":"Studying gene and gene-environment effects of uncommon and common variants on continuous traits: a marker-set approach using gene-trait similarity regression","volume":"89","author":"Tzeng","year":"2011","journal-title":"Am J Hum Genet"},{"issue":"5","key":"10.1002\/gepi.21790-BIB0030|gepi21790-cit-0030","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1086\/508346","article-title":"Generalized genomic distance-based regression methodology for multilocus association analysis","volume":"79","author":"Wessel","year":"2006","journal-title":"Am J Hum Genet"},{"issue":"6","key":"10.1002\/gepi.21790-BIB0031|gepi21790-cit-0031","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.ajhg.2010.05.002","article-title":"Powerful SNP-set analysis for case-control genome-wide association studies","volume":"86","author":"Wu","year":"2010","journal-title":"Am J Hum Genet"},{"issue":"1","key":"10.1002\/gepi.21790-BIB0032|gepi21790-cit-0032","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.ajhg.2011.05.029","article-title":"Rare-variant association testing for sequencing data with the sequence kernel association test","volume":"89","author":"Wu","year":"2011","journal-title":"Am J Hum Genet"},{"issue":"5","key":"10.1002\/gepi.21790-BIB0033|gepi21790-cit-0033","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.ajhg.2010.10.012","article-title":"Extending rare-variant testing strategies: analysis of noncoding sequence and imputed genotypes","volume":"87","author":"Zawistowski","year":"2010","journal-title":"Am J Hum Genet"}],"container-title":["Genetic Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgepi.21790","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1002\/gepi.21790\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T20:12:07Z","timestamp":1716495127000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gepi.21790"}},"subtitle":["Generalized Genetic Random Field Method"],"short-title":[],"issued":{"date-parts":[[2014,1,30]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,4]]}},"URL":"https:\/\/doi.org\/10.1002\/gepi.21790","archive":["Portico"],"relation":{},"ISSN":["0741-0395"],"issn-type":[{"value":"0741-0395","type":"print"}],"subject":[],"published":{"date-parts":[[2014,1,30]]}}}