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Here we assess shared genetic risk in genome\u2010wide\u2010association\u2010studies (GWAS).<\/jats:p><jats:p>Secondary analysis of GWAS of NHL subtypes (chronic lymphocytic leukemia, diffuse large B\u2010cell lymphoma, follicular lymphoma, and marginal zone lymphoma) and ADs (rheumatoid arthritis, systemic lupus erythematosus, and multiple sclerosis). Shared genetic risk was assessed by (a) description of regional genetic of overlap, (b) polygenic risk score (PRS), (c)\"diseasome\", (d)meta\u2010analysis.<\/jats:p><jats:p>Descriptive analysis revealed few shared genetic factors between each AD and each NHL subtype. The PRS of ADs were not increased in NHL patients (nor vice versa). In the diseasome, NHLs shared more genetic etiology with ADs than solid cancers (<jats:italic>p<\/jats:italic>\u2009=\u2009.0041). A meta\u2010analysis (combing AD with NHL) implicated genes of apoptosis and telomere length.<\/jats:p><jats:p>This GWAS\u2010based analysis four NHL subtypes and three ADs revealed few weakly\u2010associated shared loci, explaining little total risk. This suggests common genetic variation, as assessed by GWAS in these sample sizes, may not be the primary explanation for the link between these ADs and NHLs.<\/jats:p>","DOI":"10.1002\/gepi.22242","type":"journal-article","created":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T11:36:27Z","timestamp":1565696187000},"page":"844-863","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Genetic overlap between autoimmune diseases and non\u2010Hodgkin lymphoma subtypes"],"prefix":"10.1002","volume":"43","author":[{"given":"Lennox","family":"Din","sequence":"first","affiliation":[{"name":"College of Medicine California Northstate University  Elk Grove California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Sheikh","sequence":"additional","affiliation":[{"name":"College of Medicine California Northstate University  Elk Grove California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikitha","family":"Kosaraju","sequence":"additional","affiliation":[{"name":"Center for Neuroengineering and Therapeutics, Department of Neurology Hospital of the University of Pennsylvania  Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin Ekstrom","family":"Smedby","sequence":"additional","affiliation":[{"name":"Division of Clinical Epidemiology, Department of Medicine Karolinska Institutet  Solna Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sasha","family":"Bernatsky","sequence":"additional","affiliation":[{"name":"Faculty of Medicine McGill University  Montreal Canada"},{"name":"Clinical Epidemiology, McGill University Health Centre Research Institute  Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja I.","family":"Berndt","sequence":"additional","affiliation":[{"name":"Division of Cancer 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H.","family":"Vermeulen","sequence":"additional","affiliation":[{"name":"Division of Environmental Epidemiology, Institute for Risk Assessment Science Utrecht University  Utrecht Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger L.","family":"Milne","sequence":"additional","affiliation":[{"name":"Cancer Epidemiology Division Cancer Council Victoria  Melbourne Australia"},{"name":"Centre for Epidemiology and Biostatistics University of Melbourne  Melbourne Australia"},{"name":"Centre for Epidemiology and Intelligence Cancer Council Australia  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolph","family":"Kaaks","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology German Cancer Research Center  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth C.","family":"Travis","sequence":"additional","affiliation":[{"name":"Cancer Epidemiology Unit University of 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