{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:26:55Z","timestamp":1740104815133,"version":"3.37.3"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T00:00:00Z","timestamp":1594857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007747","name":"University of Utah","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007747","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006364","name":"Institut National Du Cancer","doi-asserted-by":"publisher","award":["P30 CA42014"],"award-info":[{"award-number":["P30 CA42014"]}],"id":[{"id":"10.13039\/501100006364","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010637","name":"Huntsman Cancer Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010637","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["NU58DP0063200\u201001"],"award-info":[{"award-number":["NU58DP0063200\u201001"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genetic Epidemiology"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Family history and body mass index (BMI) are well\u2010known risk factors for colorectal cancer (CRC), however, their joint effects are not well described. Using linked data for genealogy, self\u2010reported height and weight from driver's licenses, and the Utah Surveillance, Epidemiology, and End\u2010Results cancer registry, we found that an increasing number of first\u2010degree relatives (FDR) with CRC is associated with higher standardized incidence ratio (SIR) for overweight\/obese probands but not for under\/normal weight probands. For probands with two CRC\u2010affected FDRs, the SIR\u2009=\u20091.91 (95% CI [0.52, 4.89]) for under\/normal weight probands and SIR\u2009=\u20094.31 (95% CI [2.46, 7.00]) for overweight\/obese probands. In the absence of CRC\u2010affected FDRs, any number of CRC\u2010affected SDRs did not significantly increase CRC risk for under\/normal weight probands, but for overweight\/obese probands with at least three CRC\u2010affected SDRs the SIR\u2009=\u20092.68 (95% CI [1.29, 4.93]). In the absence of CRC\u2010affected FDRs and SDRs, any number of CRC\u2010affected third\u2010degree relatives (TDRs) did not increase risk in under\/normal weight probands, but significantly elevated risk for overweight\/obese probands with at least two CRC\u2010affected TDRs was observed; SIR\u2009=\u20091.32 (95% CI [1.04, 1.65]). For nonsyndromic CRC, maximum midlife BMI affects risk based on family history and should be taken into account for CRC risk communication when possible.<\/jats:p>","DOI":"10.1002\/gepi.22338","type":"journal-article","created":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T06:28:11Z","timestamp":1594967291000},"page":"778-784","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Colorectal cancer risk based on extended family history and body mass index"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1255-7714","authenticated-orcid":false,"given":"Heather M.","family":"Ochs\u2010Balcom","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Environmental Health, School of Public Health and Health Professions University at Buffalo Buffalo New York"},{"name":"Huntsman Cancer Institute Salt Lake City Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priyanka","family":"Kanth","sequence":"additional","affiliation":[{"name":"Huntsman Cancer Institute Salt Lake City Utah"},{"name":"Division of Gastroenterology, Department of Internal Medicine University of Utah School of Medicine Salt Lake City Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James M.","family":"Farnham","sequence":"additional","affiliation":[{"name":"Division of Genetic Epidemiology, Department of Internal Medicine University of Utah School of Medicine Salt Lake City Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samir","family":"Abdelrahman","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics University of Utah School of Medicine Salt Lake City Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2602-3668","authenticated-orcid":false,"given":"Lisa A.","family":"Cannon\u2010Albright","sequence":"additional","affiliation":[{"name":"Huntsman Cancer Institute Salt Lake City Utah"},{"name":"Division of Genetic Epidemiology, Department of Internal Medicine University of Utah School of Medicine Salt Lake City Utah"},{"name":"George E. Wahlen Department of Veterans Affairs Medical Center Salt Lake City Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,16]]},"reference":[{"volume-title":"Categorical data analysis","year":"1990","author":"Agresti A.","key":"e_1_2_8_2_1"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2013.09.006"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41395-018-0402-3"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(03)00420-9"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.01.057"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/218250"},{"issue":"288","key":"e_1_2_8_8_1","first-page":"1","article-title":"Prevalence of obesity among adults and youth: United States, 2015\u20132016","author":"Hales C. 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