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Our aim is to assess parent\u2010of\u2010origin (PoO) effects on childhood asthma by analyzing SNP array genotype data from a large population\u2010based cohort. To estimate PoO effects in parent\u2010reported childhood asthma at 7 years of age, we fit a log\u2010linear model implemented in the HAPLIN R package to SNP array genotype data from 915 mother\u2013father\u2013child case triads, 603 mother\u2013child case dyads, and 113 father\u2013child case dyads participating in the Norwegian Mother, Father, and Child Cohort Study (MoBa). We found that alleles at two SNPs\u2014rs3003214 and rs3003211\u2014near the adenylosuccinate synthase 2 gene (<jats:italic>ADSS2<\/jats:italic> on chromosome 1q44) showed significant PoO effects at a false positive rate\u2009\u2264\u20090.05. The ratio of the effect of the maternally and paternally inherited G\u2010allele at rs3003214 was 1.68 (95% CI: 1.41\u20132.03, <jats:italic>p<\/jats:italic> value\u2009=\u20091.13E\u221208). Our results suggest PoO effects at the <jats:italic>ADSS2<\/jats:italic> gene, particularly the maternally inherited G\u2010allele at rs3003214, may contribute to the maternal effect in childhood asthma.<\/jats:p>","DOI":"10.1002\/gepi.70007","type":"journal-article","created":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T07:12:23Z","timestamp":1743145943000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Parent\u2010of\u2010Origin Effects in Childhood Asthma at Seven Years of Age"],"prefix":"10.1002","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2512-1082","authenticated-orcid":false,"given":"Yunsung","family":"Lee","sequence":"first","affiliation":[{"name":"Centre for Fertility and Health Norwegian Institute of Public Health Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam","family":"Gjerdevik","sequence":"additional","affiliation":[{"name":"Centre for Fertility and Health Norwegian Institute of Public Health Oslo Norway"},{"name":"Department of Computer Science, Electrical Engineering and Mathematical Sciences Western Norway University of Applied Sciences Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Astanand","family":"Jugessur","sequence":"additional","affiliation":[{"name":"Centre for Fertility and Health Norwegian Institute of Public Health Oslo Norway"},{"name":"Department of Global Public Health and Primary Care University of Bergen Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e5kon Kristian","family":"Gjessing","sequence":"additional","affiliation":[{"name":"Centre for Fertility and Health Norwegian Institute of Public Health Oslo Norway"},{"name":"Department of Global Public Health and Primary Care University of Bergen Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Corfield","sequence":"additional","affiliation":[{"name":"PsychGen Centre for Genetic Epidemiology and Mental Health Norwegian Institute of Public Health Oslo Norway"},{"name":"Nic Waals Institute Lovisenberg Diaconal Hospital Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Havdahl","sequence":"additional","affiliation":[{"name":"PsychGen Centre for Genetic Epidemiology and Mental Health Norwegian Institute of Public Health Oslo Norway"},{"name":"Nic Waals Institute Lovisenberg Diaconal Hospital Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer Ruth","family":"Harris","sequence":"additional","affiliation":[{"name":"Centre for Fertility and Health Norwegian Institute of Public Health Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Christine","family":"Magnus","sequence":"additional","affiliation":[{"name":"Centre for Fertility and Health Norwegian Institute of Public Health Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siri Eldevik","family":"H\u00e5berg","sequence":"additional","affiliation":[{"name":"Centre for Fertility and Health Norwegian Institute of Public Health Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per","family":"Magnus","sequence":"additional","affiliation":[{"name":"Centre for Fertility and Health Norwegian Institute of Public Health Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,25]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.20547"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.1.191"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1120666109"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2013.01.021"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-23715-7"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24043462"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)91468-n"},{"key":"e_1_2_12_9_1","article-title":"The Norwegian Mother, Father, and Child Cohort Study (MoBa) Genotyping Data Resource: MoBaPsychGen Pipeline v.1","volume":"2022","author":"Corfield E. 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