{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T06:48:48Z","timestamp":1782542928804,"version":"3.54.5"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["F99AG07979"],"award-info":[{"award-number":["F99AG07979"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["K01AG071689"],"award-info":[{"award-number":["K01AG071689"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genetic Epidemiology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Over 75 Alzheimer's disease (AD) and dementia\u2010associated variants have been identified through genome\u2010wide association studies, but the utility of polygenic risk scores (PRS) for predicting AD and dementia in diverse and admixed populations remains unclear. We compared how PRS approaches differing in\n                    <jats:italic>p<\/jats:italic>\n                    \u2010value thresholds, variant weights, and source ancestry perform in predicting dementia in 6338 African American, Chinese, Hispanic, and White individuals from the Multi\u2010Ethnic Study of Atherosclerosis. We tested clumping and thresholding (C+T) methods with varying parameters against Bayesian approaches (PRS\u2010CS, PRS\u2010CSx). We compared the ability of each method to predict incident dementia in all participants and in groups stratified by self\u2010reported race\/ethnicity. We additionally analyzed performance across groups stratified by estimated proportion of non\u2010Finnish European (NFE)\u2010like ancestry. Including more variants does not improve performance. We found comparable associations between dementia and PRS when comparing a C+T method with only 15 SNPs and PRS derived from Bayesian models that include &gt;\u2009800,000 SNPs (HR\n                    <jats:sub>5e\u201008<\/jats:sub>\n                    = 1.18, 95% CI: 1.08\u20131.28; HR\n                    <jats:sub>CSx<\/jats:sub>\n                    = 1.17, 95% CI: 1.07\u22121.27). The\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20095e\u201008 C+T method was more strongly associated with incident dementia in populations genetically dissimilar from the source data (HR\n                    <jats:sub>lowNFE<\/jats:sub>\n                    _\n                    <jats:sub>5e\u201008<\/jats:sub>\n                    = 1.27, 95% CI: 1.08\u22121.50; HR\n                    <jats:sub>lowNFE<\/jats:sub>\n                    _\n                    <jats:sub>CSx<\/jats:sub>\n                    = 1.12, 95% CI: 0.94\u22121.33). More selective PRS models using genome\u2010wide significant SNPs may be preferable for dementia prediction in diverse populations.\n                  <\/jats:p>","DOI":"10.1002\/gepi.70046","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T11:31:42Z","timestamp":1782214302000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Polygenic Risk Scores for Incident Dementia in the Multi\u2010Ethnic Study of Atherosclerosis"],"prefix":"10.1002","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7633-2253","authenticated-orcid":false,"given":"Diane","family":"Xue","sequence":"first","affiliation":[{"name":"Department of Genetics University of Pennsylvania Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0633-0305","authenticated-orcid":false,"given":"Elizabeth E.","family":"Blue","sequence":"additional","affiliation":[{"name":"Division of Medical Genetics, Department of Medicine University of Washington Seattle WA USA"},{"name":"Institute for Public Health Genetics University of Washington Seattle WA USA"},{"name":"Brotman Baty Institute Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamar","family":"Sofer","sequence":"additional","affiliation":[{"name":"CardioVascular Institute, Beth Israel Deaconess Medical Center, Harvard Medical School Boston MA USA"},{"name":"Department of Biostatistics Harvard T.H. Chan School of Public Health Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy M.","family":"Hughes","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section on Gerontology and Geriatric Medicine Wake Forest University School of Medicine Winston\u2010Salem NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerome I.","family":"Rotter","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor\u2010UCLA Medical Center Institute for Translational Genomics and Population Sciences Torrance CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy S.","family":"Post","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine Johns Hopkins University Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison E.","family":"Fohner","sequence":"additional","affiliation":[{"name":"Institute for Public Health Genetics University of Washington Seattle WA USA"},{"name":"Department of Epidemiology University of Washington Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","unstructured":"2024 Alzheimer's Disease Facts and Figures.2024.Alzheimer's & Dementia 20 no. 5: 3708\u20133821.https:\/\/doi.org\/10.1002\/alz.13809.","DOI":"10.1002\/alz.13809"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2023.104511"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature15393"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-022-01024-z"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-024-01664-9"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2008.10.008"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwf113"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1534\/g3.120.401658"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2019.07.016"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1086\/302553"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13742-015-0047-8"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-020-0353-1"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06079-4"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv268"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0000000000000164"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09718-5"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xhgg.2024.100355"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-01767-6"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2016.12.012"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.47162"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2308-7"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-019-0358-2"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2020.3536"},{"key":"e_1_2_9_25_1","first-page":"R133","volume-title":"Human Molecular Genetics","author":"Lambert S. 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