{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T09:42:58Z","timestamp":1792662178415,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","award":["NIHR203330"],"award-info":[{"award-number":["NIHR203330"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002999","name":"Ministerie van Volksgezondheid, Welzijn en Sport","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002999","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016238","name":"Ministerie van Economische Zaken en Klimaat","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016238","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005075","name":"Universitair Medisch Centrum Groningen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005075","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genetic Epidemiology"],"published-print":{"date-parts":[[2026,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    High blood pressure (BP) represents a major cause of life\u2010threatening cardiovascular conditions. GWAS have identified &gt;2000 BP\u2010associated signals. BP\u2010GWAS usually analyze each BP trait individually. However, multi\u2010trait GWAS may yield novel loci and improve polygenic risk scores (PRS) prediction. We explored whether multi\u2010trait BP\u2010GWAS can: (i) find novel loci undetected by single\u2010trait GWAS; (ii) increase heritability estimates; (iii) improve PRS prediction of hypertension within the Lifelines Cohort Study. We investigate the utility of multi\u2010trait GWAS approaches of correlated BP traits (systolic BP, diastolic BP, pulse pressure). We tested two multi\u2010trait methods inputting results from the latest\n                    <jats:italic>N<\/jats:italic>\n                    \u2009&gt;\u20091 million single\u2010trait BP\u2010GWAS: (a) Multi\u2010Trait Analysis of GWAS (MTAG); (b) genomic structural equation modeling (GenomicSEM); and compared results with single\u2010trait results. We only identified one novel locus from multi\u2010trait GWAS:\n                    <jats:italic>ZNF268<\/jats:italic>\n                    . Neither heritability estimates nor PRS performance improved using multi\u2010trait GWAS. In this scenario of complete sample overlap across BP\u2010GWAS, we observed little gain in results from multi\u2010trait BP\u2010GWAS over single\u2010trait BP\u2010GWAS. Our findings quantify the limited benefit of multi\u2010trait methods under this specific setting. Future BP genetic discoveries are more likely to come from larger GWAS adding new cohort data. However, conclusions may differ for other traits, depending on trait\u2010specific genetic architecture.\n                  <\/jats:p>","DOI":"10.1002\/gepi.70062","type":"journal-article","created":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T09:27:07Z","timestamp":1792661227000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multi\u2010Trait GWAS Analyses of Blood Pressure Traits Provide Limited Gains in Locus Discovery or Polygenic Risk Score Performance Compared to Single\u2010Trait GWAS"],"prefix":"10.1002","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-3307-8874","authenticated-orcid":false,"given":"Yujia","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Epidemiology University of Groningen, University Medical Center Groningen Groningen the Netherlands"},{"name":"Department of Non\u2010communicable Chronic Disease Control and Prevention Beijing Center for Disease Prevention and Control Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5211-4497","authenticated-orcid":false,"given":"Anna D.","family":"Argoty\u2010Pantoja","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University of Groningen, University Medical Center Groningen Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University of Groningen, University Medical Center Groningen Groningen the Netherlands"},{"name":"Guangzhou National Laboratory Guangdong Province Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9097-7381","authenticated-orcid":false,"given":"Michael R.","family":"Barnes","sequence":"additional","affiliation":[{"name":"William Harvey Research Institute, Barts and The London Faculty of Medicine and Dentistry Queen Mary University of London London UK"},{"name":"National Institute for Health and Care Research, Barts Cardiovascular Biomedical Research Centre Queen Mary University of London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4176-2947","authenticated-orcid":false,"given":"Patricia B.","family":"Munroe","sequence":"additional","affiliation":[{"name":"William Harvey Research Institute, Barts and The London Faculty of Medicine and Dentistry Queen Mary University of London London UK"},{"name":"National Institute for Health and Care Research, Barts Cardiovascular Biomedical Research Centre Queen Mary University of London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2205-5315","authenticated-orcid":false,"given":"Claudia P.","family":"Cabrera","sequence":"additional","affiliation":[{"name":"William Harvey Research Institute, Barts and The London Faculty of Medicine and Dentistry Queen Mary University of London London UK"},{"name":"National Institute for Health and Care Research, Barts Cardiovascular Biomedical Research Centre Queen Mary University of London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1949-2298","authenticated-orcid":false,"given":"Harold","family":"Snieder","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University of Groningen, University Medical Center Groningen Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0511-1386","authenticated-orcid":false,"given":"Helen R.","family":"Warren","sequence":"additional","affiliation":[{"name":"William Harvey Research Institute, Barts and The London Faculty of Medicine and Dentistry Queen Mary University of London London UK"},{"name":"National Institute for Health and Care Research, Barts Cardiovascular Biomedical Research Centre Queen Mary University of London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"UMCG Genetics Lifelines Initiative (UGLI) group author: LifeLines Cohort Study","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,22]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"Ani A. 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