{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T01:19:43Z","timestamp":1777339183498,"version":"3.51.4"},"reference-count":65,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T00:00:00Z","timestamp":1660867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Genetics"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In this article, a caveat for advancing the genetics of Lewy body disorders is raised, given the nosological controversy about whether to consider dementia with Lewy bodies (DLB) and Parkinson's disease (PD) as one entity or two separate entities. Using the framework of the sufficient and component causes model of causation, as further developed into an evolution\u2010based model of causation, it is proposed that a disease of complex etiology is defined as having a relatively high degree of sharing of the component causes (a genetic or environmental factor), that is, a low degree of heterogeneity of the sufficient causes. Based on this definition, only if the sharing of component causes within each of two diseases is similar to their combined sharing can lumping be warranted. However, it is not known whether the separate and combined sharing are similar before conducting the etiologic studies. This means that lumping DLB and PD can be counterproductive as it can decrease the ability to detect component causes despite the potential benefit of conducting studies with larger sample sizes. In turn, this is relevant to the development of disease\u2010modifying treatments, because non\u2010overlapping causal genetic factors may result in distinct pathogenetic pathways providing promising targets for interventions.<\/jats:p>","DOI":"10.1002\/ggn2.202200011","type":"journal-article","created":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T23:30:33Z","timestamp":1660951833000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Advancing the Genetics of Lewy Body Disorders with Disease\u2010Modifying Treatments in Mind"],"prefix":"10.1002","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2422-9825","authenticated-orcid":false,"given":"Gilberto","family":"Levy","sequence":"first","affiliation":[{"name":"Rio de Janeiro 22441\u2010012 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0933-2437","authenticated-orcid":false,"given":"Bruce","family":"Levin","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Mailman School of Public Health Columbia University  New York 10032 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4168-1992","authenticated-orcid":false,"given":"Eliasz","family":"Engelhardt","sequence":"additional","affiliation":[{"name":"Instituto de Neurologia Deolindo Couto and Instituto de Psiquiatria Universidade Federal do Rio de Janeiro  Rio de Janeiro 22290\u2010140 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,19]]},"reference":[{"key":"e_1_2_7_1_1","volume-title":"An Essay on the Shaking Palsy","author":"Parkinson J.","year":"1817"},{"key":"e_1_2_7_2_1","volume-title":"De la Paralysie Agitante","author":"Charcot J. 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