{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:57:15Z","timestamp":1760576235737,"version":"build-2065373602"},"reference-count":114,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T00:00:00Z","timestamp":1667779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Genetics"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In sudden unexplained death in pediatrics (SUDP) the cause of death is unknown despite an autopsy and investigation. The role of copy number variations (CNVs) in SUDP has not been well\u2010studied. Chromosomal microarray (CMA) data are generated for 116 SUDP cases with age at death between 1 and 28 months. CNVs are classified using the American College of Medical Genetics and Genomics guidelines and CNVs in our cohort are compared to an autism spectrum disorder (ASD) cohort, and to a control cohort. Pathogenic CNVs are identified in 5 of 116 cases (4.3%). Variants of uncertain significance (VUS) favoring pathogenic CNVs are identified in 9 cases (7.8%). Several CNVs are associated with neurodevelopmental phenotypes including seizures, ASD, developmental delay, and schizophrenia. The structural variant 47,XXY is identified in two cases (2\/69 boys, 2.9%) not previously diagnosed with Klinefelter syndrome. Pathogenicity scores for deletions are significantly elevated in the SUDP cohort versus controls (<jats:italic>p<\/jats:italic> = 0.007) and are not significantly different from the ASD cohort. The finding of pathogenic or VUS favoring pathogenic CNVs, or structural variants, in 12.1% of cases, combined with the observation of higher pathogenicity scores for deletions in SUDP versus controls, suggests that CMA should be included in the genetic evaluation of SUDP.<\/jats:p>","DOI":"10.1002\/ggn2.202200012","type":"journal-article","created":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T03:05:13Z","timestamp":1667790313000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Copy Number Variation and Structural Genomic Findings in 116 Cases of Sudden Unexplained Death between 1 and 28 Months of Age"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7371-0340","authenticated-orcid":false,"given":"Catherine A.","family":"Brownstein","sequence":"first","affiliation":[{"name":"Robert's Program on Sudden Unexplained Death in Pediatrics Boston Children's Hospital  Boston MA 02115 USA"},{"name":"Division of Genetics and Genomics Boston Children's Hospital  Boston MA 02115 USA"},{"name":"The Manton Center for Orphan Disease Research Boston Children's Hospital  Boston MA 02115 USA"},{"name":"Department of Pediatrics Harvard Medical School  Boston MA 02115 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elise","family":"Douard","sequence":"additional","affiliation":[{"name":"Sainte Justine Hospital Research Center  Montreal Quebec H3T 1C5 Canada"},{"name":"Department of Neuroscience University of Montreal  Montreal Quebec H3C 3J7 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin L.","family":"Haynes","sequence":"additional","affiliation":[{"name":"Robert's Program on Sudden Unexplained Death in Pediatrics Boston Children's Hospital  Boston MA 02115 USA"},{"name":"Department of Pathology Boston Children's Hospital and Harvard Medical School  Boston MA 02115 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun Yong","family":"Koh","sequence":"additional","affiliation":[{"name":"Robert's Program on Sudden Unexplained Death in Pediatrics Boston Children's Hospital  Boston MA 02115 USA"},{"name":"Division of Genetics and Genomics Boston Children's Hospital  Boston MA 02115 USA"},{"name":"The Manton Center for Orphan Disease Research Boston Children's Hospital  Boston MA 02115 USA"},{"name":"Epilepsy Genetics Program Department of Neurology Boston Children's Hospital  Boston MA 02115 USA"},{"name":"F. M. Kirby Neurobiology Center Department of Neurology Boston Children's Hospital  Boston MA 02115 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alireza","family":"Haghighi","sequence":"additional","affiliation":[{"name":"Department of Genetics Harvard Medical School  Boston MA 02115 USA"},{"name":"Department of Medicine Brigham and Women's Hospital Harvard Medical School  Boston MA 02115 USA"},{"name":"The Broad Institute  415 Main St Cambridge MA 02142 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Keywan","sequence":"additional","affiliation":[{"name":"Robert's Program on Sudden Unexplained Death in Pediatrics Boston Children's Hospital  Boston MA 02115 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bree","family":"Martin","sequence":"additional","affiliation":[{"name":"Robert's Program on Sudden Unexplained Death in Pediatrics Boston Children's Hospital  Boston MA 02115 USA"},{"name":"Division of General Pediatrics Department of Pediatrics Boston Children's Hospital  Boston MA 02115 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanda","family":"Alexandrescu","sequence":"additional","affiliation":[{"name":"Robert's Program on Sudden Unexplained Death in Pediatrics Boston Children's Hospital  Boston MA 02115 USA"},{"name":"Department of Pathology Boston Children's Hospital and Harvard Medical School  Boston MA 02115 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth A.","family":"Haas","sequence":"additional","affiliation":[{"name":"Department of Research Rady Children's Hospital\u2010San Diego  San Diego CA 92123 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara O.","family":"Vargas","sequence":"additional","affiliation":[{"name":"Robert's Program on Sudden Unexplained Death in Pediatrics Boston Children's Hospital  Boston MA 02115 USA"},{"name":"Department of Pathology Boston Children's Hospital and Harvard Medical School  Boston MA 02115 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica H.","family":"Wojcik","sequence":"additional","affiliation":[{"name":"Robert's Program on Sudden Unexplained Death in Pediatrics Boston Children's Hospital  Boston MA 02115 USA"},{"name":"Division of Genetics and Genomics Boston Children's Hospital  Boston MA 02115 USA"},{"name":"The Manton Center for Orphan Disease Research Boston Children's Hospital  Boston MA 02115 USA"},{"name":"Division of Newborn Medicine Department of Pediatrics Boston Children's Hospital  Boston MA 02115 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e9bastien","family":"Jacquemont","sequence":"additional","affiliation":[{"name":"Sainte Justine Hospital Research Center  Montreal Quebec H3T 1C5 Canada"},{"name":"Department of Neuroscience University of Montreal  Montreal Quebec H3C 3J7 Canada"},{"name":"Department of Pediatrics University of Montreal  Quebec H3T 1C5 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annapurna H.","family":"Poduri","sequence":"additional","affiliation":[{"name":"Robert's Program on Sudden Unexplained Death in Pediatrics Boston Children's Hospital  Boston MA 02115 USA"},{"name":"Epilepsy Genetics Program Department of Neurology Boston Children's Hospital  Boston MA 02115 USA"},{"name":"F. M. Kirby Neurobiology Center Department of Neurology Boston Children's Hospital  Boston MA 02115 USA"},{"name":"Department of Neurology Harvard Medical School  Boston MA 02115 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard D.","family":"Goldstein","sequence":"additional","affiliation":[{"name":"Robert's Program on Sudden Unexplained Death in Pediatrics Boston Children's Hospital  Boston MA 02115 USA"},{"name":"Department of Pediatrics Harvard Medical School  Boston MA 02115 USA"},{"name":"Division of General Pediatrics Department of Pediatrics Boston Children's Hospital  Boston MA 02115 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingrid A.","family":"Holm","sequence":"additional","affiliation":[{"name":"Robert's Program on Sudden Unexplained Death in Pediatrics Boston Children's Hospital  Boston MA 02115 USA"},{"name":"Division of Genetics and Genomics Boston Children's Hospital  Boston MA 02115 USA"},{"name":"The Manton Center for Orphan Disease Research Boston Children's Hospital  Boston MA 02115 USA"},{"name":"Department of Pediatrics Harvard Medical School  Boston MA 02115 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,11,7]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12024-019-00156-9"},{"key":"e_1_2_9_2_1","unstructured":"Centers for Disease Control and Prevention Multiple Cause of Death 1999\u20102020 http:\/\/wonder.cdc.gov\/mcd-icd10.html(accessed: August 2022)."},{"key":"e_1_2_9_3_1","first-page":"404","volume":"25","author":"Neubauer J.","year":"2017","journal-title":"Eur. J. Med. Genet."},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.01.030"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gim.2021.12.004"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mgg3.1309"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.14055"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2115140118"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2011-200218"},{"key":"e_1_2_9_10_1","first-page":"711","volume-title":"SIDS Sudden Infant and Early Childhood Death: The Past, the Present and the Future","author":"Brownstein C. A.","year":"2018"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.2147\/TACG.S239478"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.05.002"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-201011000-00003"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1138659"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-201011000-00003"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.5535\/arm.2019.43.2.215"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61109-9"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.20844"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08979"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22645"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa171"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2010.04.006"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2017.1775"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3343\/alm.2019.39.3.299"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-1684"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2013.129"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3343\/alm.2018.38.5.473"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/ppe.12136"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2018.01.005"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1203382"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2817"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmoldx.2013.03.006"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1159\/000361017"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2015.04.010"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14866"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1201569"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12024-018-0068-6"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2009.01161.x"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-4661"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1908753"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12024-015-9724-2"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-014-1357-0"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e3182217a3a"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2287-8"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2016.08.014"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2308-7"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.23763"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2010.4"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dys084"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyr197"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.10.006"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4524"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-020-00985-z"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky955"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.2018.301"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/mgg3.1309"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.35780"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1101\/mcs.a003442"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2019.10.010"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2019.10.007"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2001.tb00395.x"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1159\/000444596"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/cge.12332"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-020-0725-x"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-011-0970-4"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2009.03.010"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2018-105879"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2018.17040467"},{"key":"e_1_2_9_69_1","unstructured":"National Center for Biotechnology Information https:\/\/www.ncbi.nlm.nih.gov\/clinvar\/variation\/VCV000395487.3(accessed: August 2022)."},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2011.08.008"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2008.063818"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14632-6"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07398"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.51040"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-016-3091-6"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6974(96)00071-0"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0161045"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2010.02691.x"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2019.10.005"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2007.01439_2.x"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4199-09.2010"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5327"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2014.03.007"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2018.01.021"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1210\/js.2019-00241"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2016.23"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2019.3779"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2015.01.002"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms16024068"},{"key":"e_1_2_9_90_1","first-page":"1240","volume":"20","author":"Schaaf C. P.","year":"2012","journal-title":"Eur. J. Med. Genet."},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2020.104002"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2018.08.011"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-8994(98)00055-1"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02282994"},{"key":"e_1_2_9_95_1","first-page":"28","volume":"14","author":"Takei H.","year":"1969","journal-title":"Jinrui Idengaku Zasshi"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2018.07.015"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1186\/2049-9256-1-4"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.32148"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp262"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.2739"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1726-4901(09)70098-X"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1212\/NXG.0000000000000056"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2012.02.007"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.2350\/08-09-0542.1"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2016.05.006"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S142032"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.2040-4603.2015.tb00632.x"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjog.2016.12.002"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2012.164"},{"key":"e_1_2_9_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2008.12.014"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.909"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31327"},{"key":"e_1_2_9_113_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-8666-8_16"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-019-0599-y"}],"container-title":["Advanced Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ggn2.202200012","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ggn2.202200012","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ggn2.202200012","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:28:33Z","timestamp":1760549313000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/ggn2.202200012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,7]]},"references-count":114,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["10.1002\/ggn2.202200012"],"URL":"https:\/\/doi.org\/10.1002\/ggn2.202200012","archive":["Portico"],"relation":{},"ISSN":["2641-6573","2641-6573"],"issn-type":[{"type":"print","value":"2641-6573"},{"type":"electronic","value":"2641-6573"}],"subject":[],"published":{"date-parts":[[2022,11,7]]},"assertion":[{"value":"2022-03-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2200012"}}