{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:59:16Z","timestamp":1760576356446,"version":"build-2065373602"},"reference-count":54,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T00:00:00Z","timestamp":1699401600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017596","name":"Natural Science Basic Research Program of Shaanxi Province","doi-asserted-by":"publisher","award":["2021JCW\u201008"],"award-info":[{"award-number":["2021JCW\u201008"]}],"id":[{"id":"10.13039\/501100017596","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Genetics"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Observational studies have shown that alterations in gut microbiota composition are associated with low back pain. However, it remains unclear whether the association is causal. To reveal the causal association between gut microbiota and low back pain, a two\u2010sample bidirectional Mendelian randomization (MR) analysis is performed. The inverse variance weighted regression (IVW) is performed as the principal MR analysis. MR\u2010Egger and Weighted Median is further conducted as complementary analysis to validate the robustness of the results. Finally, a reverse MR analysis is performed to evaluate the possibility of reverse causation. The inverse variance weighted (IVW) method suggests that <jats:italic>Peptostreptococcaceae<\/jats:italic> (odds ratio [OR] 1.056, 95% confidence interval [CI] [1.015\u20131.098], <jats:italic>P<\/jats:italic><jats:sub>IVW<\/jats:sub> = 0.010), and <jats:italic>Lactobacillaceae<\/jats:italic> (OR 1.070, 95% CI [1.026\u20131.115], <jats:italic>P<\/jats:italic><jats:sub>IVW<\/jats:sub> = 0.003) are positively associated with back pain. The <jats:italic>Ruminococcaceae<\/jats:italic> (OR 0.923, 95% CI [0.849\u20130.997], <jats:italic>P<\/jats:italic><jats:sub>IVW<\/jats:sub> = 0.033), <jats:italic>Butyricicoccus<\/jats:italic> (OR 0.920, 95% CI [0.868 \u2010 0.972], <jats:italic>P<\/jats:italic><jats:sub>IVW<\/jats:sub> = 0.002), and <jats:italic>Lachnospiraceae<\/jats:italic> (OR 0.948, 95% CI [0.903\u20130.994], <jats:italic>P<\/jats:italic><jats:sub>IVW<\/jats:sub> = 0.022) are negatively associated with back pain. In this study, underlying causal relationships are identified among gut microbiota and low back pain. Notably, further research is needed on the biological mechanisms by which gut microbiota influences low back pain.<\/jats:p>","DOI":"10.1002\/ggn2.202300192","type":"journal-article","created":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T21:59:57Z","timestamp":1699480797000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Insight into the Causal Relationship between Gut Microbiota and Back Pain: A Two Sample Bidirectional Mendelian Randomization Study"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-2391-3184","authenticated-orcid":false,"given":"Jingni","family":"Hui","sequence":"first","affiliation":[{"name":"Key Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission School of Public Health Health Science Center Xi'an Jiaotong University  Xi'an 71006 P. R. 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