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Here, we argue that their highest value for crop improvement lies not simply in additional nuclease choices, but in programmable, systems\u2010level tuning of abiotic\u2010stress defense layers, including ion homeostasis, redox buffering, osmotic adjustment, abscisic acid (ABA)\u2010centered hormone signaling, and transcriptional control. We distinguish evidence already demonstrated in stable plants, transient plant assays, or protoplasts from approaches extrapolated from Cas9\/Cas12a or non\u2010plant systems, and emphasize that many compact Cas12 applications remain platform\u2010building rather than field\u2010ready technologies. Current plant evidence supports Cas12a as a mature multiplex\u2010editing and transcriptional\u2010repression platform, Cas12f as a rapidly improving mini\u2010editor with stable and viral\u2010delivery demonstrations, and Cas12j\/CasPhi as a hypercompact system with recent crop\u2010editing and base\u2010editing potential. By contrast, Cas12g, Cas12h, Cas12lambda, and TnpB\u2010like nucleases are best viewed as promising future modules until plant\u2010active implementations are broadly validated. We offer a forward\u2010looking roadmap in which compact Cas12 systems complement Cas9 and Cas12a by enabling rapid target triage, promoter and untranslated\u2010region engineering, transient CRISPR activation\/interference, and stepwise assembly of durable sentinel edits. Translation will depend on improving efficiency and fidelity across genotypes, reducing mosaicism, documenting off\u2010target and structural variation in multiplex stacks, and aligning delivery strategies with regulatory expectations for transgene\u2010free crops.<\/jats:p>","DOI":"10.1002\/ggn2.202500067","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T07:27:57Z","timestamp":1781508477000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Compact Cas12 Systems for Multiplex Engineering of Plant Abiotic\u2010Stress Networks"],"prefix":"10.1002","volume":"7","author":[{"given":"Samar G.","family":"Thabet","sequence":"first","affiliation":[{"name":"Department of Botany Faculty of Science Fayoum University  Fayoum Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khairiah Mubarak","family":"Alwutayd","sequence":"additional","affiliation":[{"name":"Department 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