{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T19:18:57Z","timestamp":1764357537394,"version":"3.46.0"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T00:00:00Z","timestamp":1758672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical and Public Health Guidelines"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The importance of incorporating economic evidence (EE) such as resource use, cost or cost\u2010effectiveness evidence into Clinical Practice Guidelines (CPG) is being increasingly recognised by decision makers, including healthcare providers and policy makers. Yet, this is a complex and resource\u2010intensive process. EE can influence recommendations formulated about interventions in CPGs, especially when the desirable and undesirable effects are balanced. A group of methodologists, including health economists, in Gu\u00edaSalud (the organisation of the Spanish National Health System (NHS) that coordinates the national CPG Programme), has made important advances in the development of methodological guidance for how to develop evidence\u2010based recommendations. In this article, we present an algorithm for informing decisions about incorporating EE in CPGs. The algorithm has three stages: (1) prioritise clinical questions in the CPG according to the influence that EE is expected to have on recommendations; (2) obtain EE for clinical questions that have been prioritised via a systematic review and\/or a\n                    <jats:italic>de novo<\/jats:italic>\n                    economic evaluation; and (3) use EE to inform recommendations in CPG. We show how the algorithm was applied in the development of Gu\u00edaSalud's CPG for the management of chronic primary pain. In doing so, we provide specific guidance on how the algorithm could be applied using concrete examples. We show how this algorithm helps to make the process of incorporating EE into CPGs agile, dynamic and reproducible.\n                  <\/jats:p>","DOI":"10.1002\/gin2.70045","type":"journal-article","created":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T12:45:14Z","timestamp":1758717914000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An Algorithm for Incorporating Economic Evidence Into Clinical Practice Guidelines: Application to the Spanish Guideline for the Management of Chronic Primary Pain"],"prefix":"10.1002","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8877-024X","authenticated-orcid":false,"given":"Celia","family":"Mu\u00f1oz","sequence":"first","affiliation":[{"name":"Instituto Aragon\u00e9s de Ciencias de la Salud Zaragoza Arag\u00f3n Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Gav\u00edn\u2010Benavent","sequence":"additional","affiliation":[{"name":"Instituto Aragon\u00e9s de Ciencias de la Salud Zaragoza Arag\u00f3n Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4733-5601","authenticated-orcid":false,"given":"Silvia","family":"Moler\u2010Zapata","sequence":"additional","affiliation":[{"name":"Instituto Aragon\u00e9s de Ciencias de la Salud Zaragoza Arag\u00f3n Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luc\u00eda","family":"Prieto Rem\u00f3n","sequence":"additional","affiliation":[{"name":"Instituto Aragon\u00e9s de Ciencias de la Salud Zaragoza Arag\u00f3n Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Bono Vega","sequence":"additional","affiliation":[{"name":"Instituto Aragon\u00e9s de Ciencias de la Salud Zaragoza Arag\u00f3n Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1303-706X","authenticated-orcid":false,"given":"Soledad","family":"Isern de Val","sequence":"additional","affiliation":[{"name":"Instituto Aragon\u00e9s de Ciencias de la Salud Zaragoza Arag\u00f3n Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"on behalf\u2009of Gu\u00edaSalud's Working Group on Incorporating Economic Evidence into CPGs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,24]]},"reference":[{"volume-title":"Methods for the Economic Evaluation of Health Care Programmes","year":"2015","author":"Drummond M. F.","key":"e_1_2_12_2_1"},{"key":"e_1_2_12_3_1","unstructured":"Asociaci\u00f3n de Econom\u00eda de la Salud. Posici\u00f3n de la asociaci\u00f3n de econom\u00eda de la salud en relaci\u00f3n a la necesidad de un mayor uso de la evaluaci\u00f3n econ\u00f3mica en las decisiones que afectan a la financiaci\u00f3n p\u00fablica de las prestaciones y tecnolog\u00edas en el sistema nacional de salud; (2008) https:\/\/www.aes.es\/Publicaciones\/AESEE2.pdf."},{"volume-title":"Memoria de Actividades 2006\u20102016. Diez A\u00f1os Cooperando En Evaluaci\u00f3n De Tecnolog\u00edas Sanitarias","year":"2019","author":"Ministerio de Sanidad, Consumo y Bienestar Social","key":"e_1_2_12_4_1"},{"key":"e_1_2_12_5_1","unstructured":"Ministerio de Sanidad Consumo y Bienestar Social. Plan Estrat\u00e9gico RedETS 2022\u20132025. 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