{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T22:53:37Z","timestamp":1768517617530,"version":"3.49.0"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2002,3,8]],"date-time":"2002-03-08T00:00:00Z","timestamp":1015545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["Pa 328\/3"],"award-info":[{"award-number":["Pa 328\/3"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Glia"],"published-print":{"date-parts":[[2002,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>L1 is an adhesion molecule of the immunoglobulin superfamily expressed by several types of cancer, including gliomas. It has been shown that L1 can act as chemoattractant to glioma cells, while the effects of L1 expressed by glioma cells themselves are unknown to date. We established a C6 rat glioma clone, conditionally expressing murine L1 under control of a tetracycline responsive promoter. In vitro experiments revealed increased adhesion on matrigel as well as increased intercellular adhesion in the presence of L1, whereas no L1\u2010dependent effects on proliferation or migration on either matrigel or myelin were observed. In vivo experiments using transplantation into nude mouse striatum, where L1 expression by glioma cells was regulated by tetracycline via drinking water, did not show effects of L1 on tumor size or brain invasion. Our data suggest that L1 expressed on the surface of glioma cells increases cell\u2010matrix and intercellular adhesion, but has no apparent effects on proliferation and invasion. GLIA 38:146\u2013154, 2002. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/glia.10058","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T23:44:07Z","timestamp":1030319047000},"page":"146-154","source":"Crossref","is-referenced-by-count":19,"title":["L1 expressed by glioma cells promotes adhesion but not migration"],"prefix":"10.1002","volume":"38","author":[{"given":"Volker","family":"Senner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elmar","family":"Kismann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvia","family":"P\u00fcttmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norbert","family":"Hoess","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inge","family":"Baur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Werner","family":"Paulus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,3,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200003)30:3<938::AID-IMMU938>3.0.CO;2-Q"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/23.17.3605"},{"key":"e_1_2_6_4_1","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.1242\/jcs.112.16.2667","article-title":"Metalloproteinase\u2010mediated release of the ectodomain of L1 adhesion molecule","volume":"112","author":"Beer S","year":"1999","journal-title":"J Cell Sci"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.144.2.373"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01755884"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0177(200006)218:2<260::AID-DVDY3>3.0.CO;2-9"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)46961-X"},{"key":"e_1_2_6_9_1","first-page":"6364","article-title":"Differential spectrum of expression of neural cell adhesion molecule isoforms and L1 adhesion molecules on human neuroectodermal tumors","volume":"50","author":"Figarella\u2010Branger DF","year":"1990","journal-title":"Cancer Res"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.20.15490"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1997.68020544.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.490420103"},{"key":"e_1_2_6_13_1","series-title":"Cell biology: a laboratory handbook","first-page":"16","author":"Holst\u2010Hansen C","year":"1994"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80192-0"},{"key":"e_1_2_6_15_1","first-page":"1440","article-title":"Gene expression of neural cell adhesion molecule L1 in malignant gliomas and biological significance of L1 in glioma invasion","volume":"56","author":"Izumoto S","year":"1996","journal-title":"Cancer Res"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0169-328X(95)00027-P"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.110.1.193"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-0436.1997.6130143.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"crossref","first-page":"3676","DOI":"10.1523\/JNEUROSCI.20-10-03676.2000","article-title":"Recycling of the cell adhesion molecule L1 in axonal growth cones","volume":"20","author":"Kamiguchi H","year":"2000","journal-title":"J Neurosci"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.2000.0848"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1247\/csf.22.511"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/9.6.879"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M101790200"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00132985"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/372777a0"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200101099"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19991029)83:3<401::AID-IJC17>3.0.CO;2-A"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/334701a0"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004419900063"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(74)31049-X"},{"key":"e_1_2_6_31_1","first-page":"2935","article-title":"A novel model of glioma cell invasion using organotypic brain slice culture","volume":"58","author":"Ohnishi T","year":"1998","journal-title":"Cancer Res"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-3806(97)00220-4"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M004147200"},{"key":"e_1_2_6_34_1","first-page":"819","article-title":"Diffuse brain invasion of glioma cells requires \u03b21 integrins","volume":"75","author":"Paulus W","year":"1996","journal-title":"Lab Invest"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4695(20000615)43:4<389::AID-NEU7>3.0.CO;2-X"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199908000-00002"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004010051169"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.51.1.13"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-328X(96)00186-6"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4547(19970315)47:6<655::AID-JNR12>3.0.CO;2-U"}],"container-title":["Glia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fglia.10058","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/glia.10058","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T16:13:21Z","timestamp":1697559201000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/glia.10058"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,3,8]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2002,4,15]]}},"alternative-id":["10.1002\/glia.10058"],"URL":"https:\/\/doi.org\/10.1002\/glia.10058","archive":["Portico"],"relation":{},"ISSN":["0894-1491","1098-1136"],"issn-type":[{"value":"0894-1491","type":"print"},{"value":"1098-1136","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,3,8]]}}}