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After dorsal laminectomy at T8 vertebra, subjacent spinal cord was bathed with rose Bengal for 10 min and illuminated with visible light by means of an optic fiber connected to a halogen lamp for 2.5 min at maximal intensity of 8 kLux. Eight injured rats received a suspension of OECs in DMEM, and another eight rats received DMEM alone. Locomotor ability scored by the BBB scale, pain sensibility by the plantar algesimetry test, and motor\u2010 and somatosensory\u2010evoked potentials by electrophysiological techniques were evaluated for 3 months postsurgery. Finally, all rats were perfused with paraformaldehyde and transverse sections from the spinal cord segment at the lesion site were immunostained against GFAP. Area of the preserved spinal cord parenchyma was measured from the GFAP\u2010immunolabeled cord sections. The BBB score and the amplitude of motor\u2010 and somatosensory\u2010evoked potentials were higher in OECs\u2010transplanted rats than in DMEM\u2010injected animals throughout follow\u2010up, whereas the withdrawal response to heat noxious stimulus was lower in OEC\u2010 than in DMEM\u2010injected rats. The area of preserved spinal cord was significantly larger in OECs\u2010transplanted rats than in DMEM\u2010injected animals. These results indicate that OECs promote functional and morphological preservation of the spinal cord after photochemical injury. GLIA 42:275\u2013286, 2003. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/glia.10217","type":"journal-article","created":{"date-parts":[[2003,3,31]],"date-time":"2003-03-31T12:00:12Z","timestamp":1049112012000},"page":"275-286","source":"Crossref","is-referenced-by-count":70,"title":["Olfactory ensheathing cells transplanted in lesioned spinal cord prevent loss of spinal cord parenchyma and promote functional 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