{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T15:27:44Z","timestamp":1769873264182,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2003,5,14]],"date-time":"2003-05-14T00:00:00Z","timestamp":1052870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Glia"],"published-print":{"date-parts":[[2003,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The ability of resident cells to induce apoptosis of invading immune cells is a major regulatory factor operating in immune\u2010privileged tissues, including the nervous system. We investigated the cellular and molecular factors participating in modulation of immune response in peripheral nerves, focusing on two cytotoxic pathways: fas ligand (fasL) and perforin. fasL and perforin expression was found by immunochemistry on Schwann cells (Sc) in nerve biopsies from patients with chronic inflammatory demyelinating polyneuritis and on human Sc cultures. Treatment of Sc with tumor necrosis factor (TNF) \u03b1 and interferon (IFN) \u03b3 upregulated the expression of both molecules. In a coculture model, Sc exposed to TNF\u03b1 or IFN\u03b3 were able to induce both apoptotic and lytic injury of T\u2010lymphocytes. Inactivation of fasL with the neutralizing antibody NOK\u20102 abolished T\u2010cell apoptosis induced by Sc treated with TNF\u03b1, but not by Sc treated with IFN\u03b3. Conversely, T\u2010cell lysis was significantly decreased when IFN\u03b3\u2010activated Sc were treated with concanamycin A, which inhibited perforin release. At variance with T\u2010lymphocytes, B\u2010cells were less sensitive to cytokine\u2010treated Sc toxicity. Thus, Sc exposed to inflammatory cytokines have the capacity of inducing selective damage of T\u2010lymphocytes and have the potential of regulating the immune response in the peripheral nervous system. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/glia.10235","type":"journal-article","created":{"date-parts":[[2003,6,27]],"date-time":"2003-06-27T10:01:52Z","timestamp":1056708112000},"page":"141-148","source":"Crossref","is-referenced-by-count":27,"title":["T\u2010cell cytotoxicity of human Schwann cells: TNF\u03b1 promotes fasL\u2010mediated apoptosis and IFN\u03b3 perforin\u2010mediated 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