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In the present study, we demonstrate that activation of EGFR causes optic nerve astrocytes, as well as brain astrocytes, to form cribriform structures with cavernous spaces. Formation of the cribriform structures is dependent on new protein synthesis and cell proliferation. Platelet\u2010derived growth factor and basic fibroblast growth factor were not effective. Smooth muscle cells and epithelial cells do not form cribriform structures in response to EGFR activation. The formation of the cribriform structures appears to be related to a guided migration of astrocytes and the expression of integrin \u03b2<jats:sub>1<\/jats:sub> and extracellular fibronectin in response to activation of EGFR. The EGFR pathway may be a specific, signal transduction pathway that regulates reactive astrocytes to form cavernous spaces in the glial scars following CNS injury and in the compressed optic nerve in glaucomatous optic nerve neuropathy. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/glia.10358","type":"journal-article","created":{"date-parts":[[2004,3,23]],"date-time":"2004-03-23T13:38:22Z","timestamp":1080049102000},"page":"153-168","source":"Crossref","is-referenced-by-count":48,"title":["Activation of epidermal growth factor receptor causes astrocytes to form cribriform structures"],"prefix":"10.1002","volume":"46","author":[{"given":"Bin","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthur H.","family":"Neufeld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,2,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1098-1136(200103)33:3<205::AID-GLIA1019>3.0.CO;2-D"},{"key":"e_1_2_6_3_1","first-page":"181","article-title":"Integrins in cell adhesion and signaling","volume":"9","author":"Akiyama SK","year":"1996","journal-title":"Hum Cell"},{"key":"e_1_2_6_4_1","first-page":"788","volume-title":"Molecular biology of the cell","author":"Alberts B","year":"1994"},{"key":"e_1_2_6_5_1","first-page":"236","article-title":"Pathology of experimental spinal cord trauma. 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